Teia Noel
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View article: EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer
EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer Open
Phenotypic plasticity is a recognized mechanism of therapeutic resistance in prostate cancer (PCa), however current knowledge of driver mechanisms and therapeutic interventions are limited. Using genetically engineered mouse models (GEMMs)…
View article: Spatial transcriptomic analysis of immune checkpoint blockade response in triple negative breast cancers with tertiary lymphoid structures
Spatial transcriptomic analysis of immune checkpoint blockade response in triple negative breast cancers with tertiary lymphoid structures Open
Tertiary lymphoid structures (TLSs) are associated with improved cancer immunotherapy responses. However, TLSs vary in their ability to elicit anticancer immune activity, so it is important to develop databases that allow study of variable…
View article: Single RNA molecule resolution spatial imaging of immunotherapy response in triple negative breast tumors harboring tertiary lymphoid structures
Single RNA molecule resolution spatial imaging of immunotherapy response in triple negative breast tumors harboring tertiary lymphoid structures Open
Summary Cancer immunotherapy trials have had variable success, prompting a search for biomarkers of response. Tertiary lymphoid structures (TLS) have emerged as prognostic for multiple tumor types. These ectopic immunological bodies resemb…
View article: An atlas of healthy and injured cell states and niches in the human kidney
An atlas of healthy and injured cell states and niches in the human kidney Open
Understanding kidney disease relies on defining the complexity of cell types and states, their associated molecular profiles and interactions within tissue neighbourhoods 1 . Here we applied multiple single-cell and single-nucleus assays (…
View article: High-resolution Slide-seqV2 spatial transcriptomics enables discovery of disease-specific cell neighborhoods and pathways
High-resolution Slide-seqV2 spatial transcriptomics enables discovery of disease-specific cell neighborhoods and pathways Open
High-resolution spatial transcriptomics enables mapping of RNA expression directly from intact tissue sections; however, its utility for the elucidation of disease processes and therapeutically actionable pathways remains unexplored. We ap…
View article: Principles of Spatial Transcriptomics Analysis: A Practical Walk-Through in Kidney Tissue
Principles of Spatial Transcriptomics Analysis: A Practical Walk-Through in Kidney Tissue Open
Spatial transcriptomic technologies capture genome-wide readouts across biological tissue space. Moreover, recent advances in this technology, including Slide-seqV2, have achieved spatial transcriptomic data collection at a near-single cel…
View article: High Resolution Slide-seqV2 Spatial Transcriptomics Enables Discovery of Disease-Specific Cell Neighborhoods and Pathways
High Resolution Slide-seqV2 Spatial Transcriptomics Enables Discovery of Disease-Specific Cell Neighborhoods and Pathways Open
High resolution spatial transcriptomics is a transformative technology that enables mapping of RNA expression directly from intact tissue sections; however, its utility for the elucidation of disease processes and therapeutically actionabl…
View article: HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes
HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes Open
Significance Gene expression is precisely controlled across human cell types to control cellular functions and phenotypes. Here we present a technology to quantify the level of expression of genes in single cells, which will help to unders…
View article: HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes
HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes Open
Single-cell quantification of RNAs is important for understanding cellular heterogeneity and gene regulation, yet current approaches suffer from low sensitivity for individual transcripts, limiting their utility for many applications. Here…
View article: Dual RNA-Seq of Human Leprosy Lesions Identifies Bacterial Determinants Linked to Host Immune Response
Dual RNA-Seq of Human Leprosy Lesions Identifies Bacterial Determinants Linked to Host Immune Response Open
To understand how the interaction between an intracellular bacterium and the host immune system contributes to outcome at the site of infection, we studied leprosy, a disease that forms a clinical spectrum, in which progressive infection b…
View article: A Web Interface for Quantifying the Immune Cell Composition of Tissue Transcriptomes
A Web Interface for Quantifying the Immune Cell Composition of Tissue Transcriptomes Open
We developed a web tool, SaVanTv2.0, that leverages cell type signatures, or genes highly expressed in cell types, for characterizing the underlying cell populations of gene expression data. SaVanTv2.0 offers an accessible web interface, d…
View article: Dual RNAseq of human leprosy lesions identifies bacterial determinants linked to host immune response
Dual RNAseq of human leprosy lesions identifies bacterial determinants linked to host immune response Open
Summary To understand how the interaction between an intracellular bacterium and the host immune system contributes to outcome at the site of infection, we studied leprosy, a disease that forms a clinical spectrum, in which progressive inf…