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View article: Total Synthesis of Rohitukine and Dysoline and Their Anticancer Analogues Flavopiridol and IIIM-290
Total Synthesis of Rohitukine and Dysoline and Their Anticancer Analogues Flavopiridol and IIIM-290 Open
Rohitukine is a naturally occurring piperidine alkaloid that has led to the discovery of several potent CDK9/T1 inhibitors, including flavopiridol and IIIM-290. (-)-(3S,4R)-1-Methyl-4-(2,4,6-trimethoxyphenyl)-piperidin-3-ol s…