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View article: QOL-04.<i>IN VIVO</i> MODELLING RECAPITULATES RADIOTHERAPY DELIVERY AND LATE-EFFECT PROFILE FOR CHILDHOOD MEDULLOBLASTOMA
QOL-04.<i>IN VIVO</i> MODELLING RECAPITULATES RADIOTHERAPY DELIVERY AND LATE-EFFECT PROFILE FOR CHILDHOOD MEDULLOBLASTOMA Open
BACKGROUND Medulloblastoma (MB) is the most common malignant paediatric brain tumour, with 5-year survival rates >70%. Survivors frequently suffer a wide-range of late-effects due to their tumour and its treatment. Cranial radiotherapy …
View article: Brain endothelial cells promote breast cancer cell extravasation to the brain via EGFR-DOCK4-RAC1 signalling
Brain endothelial cells promote breast cancer cell extravasation to the brain via EGFR-DOCK4-RAC1 signalling Open
View article: In vivo modeling recapitulates radiotherapy delivery and late-effect profile for childhood medulloblastoma
In vivo modeling recapitulates radiotherapy delivery and late-effect profile for childhood medulloblastoma Open
Background Medulloblastoma (MB) is the most common malignant pediatric brain tumor, with 5-year survival rates > 70%. Cranial radiotherapy (CRT) to the whole brain, with posterior fossa boost (PFB), underpins treatment for non-infants; …
View article: Evaluation of the Targeting and Therapeutic Efficiency of Anti-EGFR Functionalised Nanoparticles in Head and Neck Cancer Cells for Use in NIR-II Optical Window
Evaluation of the Targeting and Therapeutic Efficiency of Anti-EGFR Functionalised Nanoparticles in Head and Neck Cancer Cells for Use in NIR-II Optical Window Open
Gold nanoparticles have been indicated for use in a diagnostic and/or therapeutic role in several cancer types. The use of gold nanorods (AuNRs) with a surface plasmon resonance (SPR) in the second near-infrared II (NIR-II) optical window …
View article: Evaluating the Targeting Efficiency of Anti-EGFR Functionalised Nanoparticles to Head and Neck Cancer Cells for Use in NIR-II Optical Window
Evaluating the Targeting Efficiency of Anti-EGFR Functionalised Nanoparticles to Head and Neck Cancer Cells for Use in NIR-II Optical Window Open
Gold nanoparticles have been indicated for use in a diagnostic and/or therapeutic role in several cancer types. The use of gold nanorods (AuNRs) with a surface plasmon resonance (SPR) in the second Near-Infrared II (NIR-II) optical window …
View article: Hematopoietic Stem Cell Gene Therapy for Brain Metastases Using Myeloid Cell–Specific Gene Promoters
Hematopoietic Stem Cell Gene Therapy for Brain Metastases Using Myeloid Cell–Specific Gene Promoters Open
Background Brain metastases (BrM) develop in 20–40% of cancer patients and represent an unmet clinical need. Limited access of drugs into the brain because of the blood-brain barrier is at least partially responsible for therapeutic failur…
View article: Rho GTPase signaling and role of the Rac1 exchange factor DOCK4 in GBM invasion and vascular growth
Rho GTPase signaling and role of the Rac1 exchange factor DOCK4 in GBM invasion and vascular growth Open
INTRODUCTION: The aggressive nature of brain tumours and resistance to therapy is highly influenced by the tumour microenvironment. A key feature of glioblastoma, also used in diagnosis, is the high degree of aberrant vascularity. Rho GTPa…
View article: P01.10 Dock4 heterozygous deletion normalizes the glioblastoma microenvironment & improves response to radiation
P01.10 Dock4 heterozygous deletion normalizes the glioblastoma microenvironment & improves response to radiation Open
\nIntroduction: Invasion and growth of brain tumours require cooperation of the tumour cell and endothelial cell compartments. Limited efficacy of anti-angiogenic therapy in glioblastoma is associated with activation of VEGF independent me…
View article: RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells
RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells Open