Tengfei Shi
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View article: Adjacent segment infection following instrumented fusion for lumbar degenerative disease: A case series of eight cases and review of literature
Adjacent segment infection following instrumented fusion for lumbar degenerative disease: A case series of eight cases and review of literature Open
Background Adjacent segment infection (ASI) following instrumented lumbar fusion for lumbar degenerative disease(LDD) remains a rarely documented complication. While a few case reports have described this entity, to our knowledge this repr…
View article: Evolutionary adaptations of a pediatric pathogen: low-inflammatory and high-resistance phenotypes in the emerging <i>Salmonella typhimurium</i> monophasic variant 1,4,[5],12:i:-
Evolutionary adaptations of a pediatric pathogen: low-inflammatory and high-resistance phenotypes in the emerging <i>Salmonella typhimurium</i> monophasic variant 1,4,[5],12:i:- Open
Salmonella enterica serovar 1,4,[5],12:i:- ( S .1,4,[5],12:i:-), a monophasic variant of Salmonella typhimurium ( S. typhimurium ), is an emerging multidrug-resistant pathogen posing a significant threat to pediatric health. Research on th…
View article: PCV2 Infection Represses the Differentiation of Light Zone Germinal Center B Cells by Inhibiting Their Interaction with Helper Cells
PCV2 Infection Represses the Differentiation of Light Zone Germinal Center B Cells by Inhibiting Their Interaction with Helper Cells Open
Porcine circovirus 2 (PCV2) is one of the most widespread immunosuppressive viruses, impairing the protective efficacy of vaccines in pig herds. Previous studies have shown that PCV2 infection reduces the generation of immune memory and an…
View article: Systematic decoding of functional enhancer connectomes and risk variants in human glioma
Systematic decoding of functional enhancer connectomes and risk variants in human glioma Open
Genetic and epigenetic variations contribute to the progression of glioma, but the mechanisms underlying these effects, particularly for enhancer-associated genetic variations in non-coding regions, still remain unclear. Here we performed …
View article: Metagenomic next-generation sequencing for the clinical identification of spinal infection-associated pathogens
Metagenomic next-generation sequencing for the clinical identification of spinal infection-associated pathogens Open
Background This study aimed to evaluate the efficacy of metagenomic next-generation sequencing (mNGS) technology for identifying pathogens associated with spinal infection (SI). Methods A retrospective analysis was conducted on clinical da…
View article: Clinical applications of metagenomic next-generation sequencing in the identification of pathogens in periprosthetic joint infections: a retrospective study
Clinical applications of metagenomic next-generation sequencing in the identification of pathogens in periprosthetic joint infections: a retrospective study Open
Background This study aimed to evaluate the application of metagenomic next-generation sequencing (mNGS) technology to identify pathogens in periprosthetic joint infection (PJI). Methods A retrospective analysis was conducted on 65 patient…
View article: Porcine circovirus type 2 infection promotes the SUMOylation of nucleophosmin-1 to facilitate the viral circular single-stranded DNA replication
Porcine circovirus type 2 infection promotes the SUMOylation of nucleophosmin-1 to facilitate the viral circular single-stranded DNA replication Open
The mechanism of genome DNA replication in circular single-stranded DNA viruses is currently a mystery, except for the fact that it undergoes rolling-circle replication. Herein, we identified SUMOylated porcine nucleophosmin-1 (pNPM1), whi…
View article: Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide
Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide Open
Glioma cell sensitivity to temozolomide (TMZ) is critical for effective treatment and correlates with patient survival, although mechanisms underlying this activity are unclear. Here, we reveal a new mechanism used by glioma cells to modul…
View article: Three-Dimensional Gene Regulation Network in Glioblastoma Ferroptosis
Three-Dimensional Gene Regulation Network in Glioblastoma Ferroptosis Open
Ferroptosis is an iron-dependent form of cell death, which is reported to be associated with glioma progression and drug sensitivity. Targeting ferroptosis is a potential therapeutic approach for glioma. However, the molecular mechanism of…
View article: Non-Typhoidal Salmonella Infections Among Children in Fuzhou, Fujian, China: A 10-Year Retrospective Review from 2012 to 2021
Non-Typhoidal Salmonella Infections Among Children in Fuzhou, Fujian, China: A 10-Year Retrospective Review from 2012 to 2021 Open
S. Typhimurium was the dominant serotype and greatly increased among children in Fuzhou city. There are significant differences in clinical symptoms, laboratory test results, and drug resistance between S. Typhimurium and non…
View article: The ultrasonically treated nanoliposomes containing PCV2 DNA vaccine expressing gC1qR binding site mutant Cap is efficient in mice
The ultrasonically treated nanoliposomes containing PCV2 DNA vaccine expressing gC1qR binding site mutant Cap is efficient in mice Open
Nowadays, vaccines are broadly used to prevent porcine circovirus type 2 (PCV2) infection-induced expenditures, but the virus is still spreading among pigs. The current PCV2 vaccines all rely on the immunogenicity of Cap, yet our previous …
View article: KLF4 inhibits early neural differentiation of ESCs by coordinating specific 3D chromatin structure
KLF4 inhibits early neural differentiation of ESCs by coordinating specific 3D chromatin structure Open
Neural differentiation of embryonic stem cells (ESCs) requires precisely orchestrated gene regulation, a process governed in part by changes in 3D chromatin structure. How these changes regulate gene expression in this context remains uncl…
View article: The gC1qR Binding Site Mutant PCV2 Is a Potential Vaccine Strain That Does Not Impair Memory CD4 <sup>+</sup> T-Cell Generation by Vaccines
The gC1qR Binding Site Mutant PCV2 Is a Potential Vaccine Strain That Does Not Impair Memory CD4 <sup>+</sup> T-Cell Generation by Vaccines Open
PCV2 is one of the costliest pathogens in pigs worldwide. Usage of PCV2 vaccines can prevent the PCV2 infection-induced clinical syndromes but not the viral spread.
View article: Identification of Olfactory Genes From the Greater Wax Moth by Antennal Transcriptome Analysis
Identification of Olfactory Genes From the Greater Wax Moth by Antennal Transcriptome Analysis Open
The olfactory system is used by insects to find hosts, mates, and oviposition sites. Insects have different types of olfactory proteins, including odorant-binding proteins (OBPs), chemosensory proteins (CSPs), odorant receptors (ORs), iono…
View article: Long-range gene regulation network of the<i>MGMT</i>enhancer in modulating glioma cell sensitivity to temozolomide
Long-range gene regulation network of the<i>MGMT</i>enhancer in modulating glioma cell sensitivity to temozolomide Open
Acquired resistance to temozolomide (TMZ) is a major obstacle in glioblastoma treatment. MGMT, a DNA repair protein, and the methylation at its gene promoter, plays an important role in TMZ resistance. However, some evidences have suggeste…
View article: A <i>HOTAIR</i> regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes
A <i>HOTAIR</i> regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes Open
Temozolomide (TMZ) is a frequently used chemotherapy for glioma; however, chemoresistance is a major problem limiting its effectiveness. Thus, knowledge of mechanisms underlying this outcome could improve patient prognosis. Here, we report…
View article: Porcine Circovirus Type 2 Rep Enhances IL-10 Production in Macrophages via Activation of p38-MAPK Pathway
Porcine Circovirus Type 2 Rep Enhances IL-10 Production in Macrophages via Activation of p38-MAPK Pathway Open
Porcine circovirus type 2 (PCV2) is one of the major threats to pig farms worldwide. Although PCV2 has been identified to promote IL-10 production, the detailed regulatory roles of PCV2 Rep for IL-10 production remain unclear. Herein, we f…
View article: A Nonsense Mutation in <i>HOXD13</i> Gene from A Chinese Family with Non-Syndromic Synpolydactyly
A Nonsense Mutation in <i>HOXD13</i> Gene from A Chinese Family with Non-Syndromic Synpolydactyly Open
Synpolydactyly is a congenital limb malformation characterized by incomplete separation and duplication in fingers and/or toes, which is mainly caused by mutations in the homeobox D13 (HOXD13) gene. Here, a four-generation family with vari…
View article: EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence
EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence Open
View article: Targeted Next-Generation Sequencing Newly Identifies Mutations in <i>Exostosin-1</i> and <i>Exostosin-2</i> Genes of Patients with Multiple Osteochondromas
Targeted Next-Generation Sequencing Newly Identifies Mutations in <i>Exostosin-1</i> and <i>Exostosin-2</i> Genes of Patients with Multiple Osteochondromas Open
Multiple osteochondromas (MO) is one of the most common benign bone tumors in humans with an autosomal dominant hereditary mode. MO is a genetic heterogeneity disease with variable number and size of osteochondromas, as well as changeable …