Terence J. Quinn
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View article: Design of Trials for Cerebral Small Vessel Disease and Vascular Cognitive Impairment
Design of Trials for Cerebral Small Vessel Disease and Vascular Cognitive Impairment Open
Background/Objectives: Cerebral small vessel disease (cSVD) and vascular cognitive impairment (VCI) are major contributors to stroke and dementia. Despite their importance, there are few effective treatments for cSVD and VCI. Variability i…
View article: Development of the Clinical Insight Questionnaire: A Novel Clinical Tool for the Assessment of Insight Into Cognitive Symptoms and Everyday Functioning in People With Neurodegeneration
Development of the Clinical Insight Questionnaire: A Novel Clinical Tool for the Assessment of Insight Into Cognitive Symptoms and Everyday Functioning in People With Neurodegeneration Open
Objectives Altered insight into cognitive symptoms and diagnosis is a common feature of neurodegeneration, and can adversely impact on quality of life and ability to access medical care. Affected individuals can lose awareness of their sym…
View article: Predicting Amyloid Positivity Through Proteomic and Machine Learning Approaches
Predicting Amyloid Positivity Through Proteomic and Machine Learning Approaches Open
Introduction Alzheimer’s disease is a progressive neurodegenerative disorder where early detection remains difficult. To address this challenge, we analysed a large proteomics dataset from older adults, including individuals diagnosed thro…
View article: Assessing Frailty and Anticholinergic Burden in the Acute Stroke Setting: A Quality Improvement Study
Assessing Frailty and Anticholinergic Burden in the Acute Stroke Setting: A Quality Improvement Study Open
View article: Change in Cognition Following Ischaemic Stroke
Change in Cognition Following Ischaemic Stroke Open
Objective Cognitive decline can occur following ischaemic stroke. How cognition changes over time and associations with cognitive change are poorly understood. This study aimed to explore these issues over 2 years following ischaemic strok…
View article: Developing treatments for cerebral small vessel disease: a scoping review of licensed interventions for potential repurposing
Developing treatments for cerebral small vessel disease: a scoping review of licensed interventions for potential repurposing Open
Background Cerebral small vessel disease (cSVD) is a progressive neurovascular-degenerative condition without specific treatment that causes lacunar stroke, most intracerebral haemorrhage, vascular cognitive impairment (VCI) and several ne…
View article: Design of Trials for Cerebral Small Vessel Disease and Vascular Cognitive Impairment
Design of Trials for Cerebral Small Vessel Disease and Vascular Cognitive Impairment Open
View article: No place like home—the importance of home in older adult research
No place like home—the importance of home in older adult research Open
View article: Tranexamic acid in reducing expected blood loss in moderate to low risk surgeries: systematic review, meta-analysis and cost effectiveness analysis
Tranexamic acid in reducing expected blood loss in moderate to low risk surgeries: systematic review, meta-analysis and cost effectiveness analysis Open
Tranexamic acid (TXA) is well-established as a safe intervention for reducing transfusion requirements in surgeries with high-risk for blood loss. However, its role in surgeries classified as low-risk for blood loss remains uncertain. Give…
View article: Cardiovascular Risk as a Moderator of the Relationship of Plasma Alzheimer's Disease Biomarkers with Cognitive Status
Cardiovascular Risk as a Moderator of the Relationship of Plasma Alzheimer's Disease Biomarkers with Cognitive Status Open
Objectives—Plasma biomarkers may assist with diagnosis and prognosis of Alzheimer's disease and other dementias. Cardiovascular risk is associated with impaired cognitive health, although mechanisms are not completely understood. We sought…
View article: The association of n-3 fatty acid intake with muscle mass and strength in older adults: A cross-sectional analysis of the UK biobank data
The association of n-3 fatty acid intake with muscle mass and strength in older adults: A cross-sectional analysis of the UK biobank data Open
View article: MetaImpact: a novel tool to enable evidence-based sample sizes for future trials
MetaImpact: a novel tool to enable evidence-based sample sizes for future trials Open
View article: Associations and interactions between premorbid cognitive health, apolipoprotein e4 genotype, and incident Alzheimer’s disease in UK Biobank (N = 252,340)
Associations and interactions between premorbid cognitive health, apolipoprotein e4 genotype, and incident Alzheimer’s disease in UK Biobank (N = 252,340) Open
It is unclear to what extent genetic risk offsets the protective effects of better premorbid cognitive health on the risk of Alzheimer’s disease (AD). We tested for associations between measures of premorbid cognitive health, apolipoprotei…
View article: Validation and Feasibility of PETS-Stroke: A Patient-Reported Measure of Treatment Burden After Stroke
Validation and Feasibility of PETS-Stroke: A Patient-Reported Measure of Treatment Burden After Stroke Open
BACKGROUND: Treatment burden is the workload of health care for people with long-term conditions and the impact on wellbeing. A validated measure of treatment burden for use as an outcome measure in stroke trials is needed. We adapted a pa…
View article: Frailty and stroke: Global implications for assessment, research, and clinical care—A WSO scientific statement
Frailty and stroke: Global implications for assessment, research, and clinical care—A WSO scientific statement Open
Frailty is common in stroke and has important disease- and treatment-modifying effects. The need to develop clinical practice and research for the impact of frailty on stroke is likely to increase in the coming decades as the global popula…
View article: Assessing the Tools for Assessing Frailty
Assessing the Tools for Assessing Frailty Open
No abstract available.
View article: Prioritizing gaps in stroke care: A two-round Delphi process
Prioritizing gaps in stroke care: A two-round Delphi process Open
Background: Despite international recognition of stroke as a significant health priority, discrepancies persist between the target values for stroke quality measures and the actual values that are achieved in clinical practice, referred to…
View article: Stroke Medicine is Frailty Medicine: Clinical and Research Priorities for Frailty in Stroke
Stroke Medicine is Frailty Medicine: Clinical and Research Priorities for Frailty in Stroke Open
View article: Prediction of dementia using CT imaging in stroke (PRODUCTS)
Prediction of dementia using CT imaging in stroke (PRODUCTS) Open
Introduction: A better understanding of who will develop dementia can inform patient care. Although MRI offers prognostic insights, access is limited globally, whereas CT-imaging is readily available in acute stroke. We explored the progno…
View article: Frailty in Stroke
Frailty in Stroke Open
View article: European Stroke Organisation (ESO) standard operating procedure for white papers (expert consensus based clinical guidance)
European Stroke Organisation (ESO) standard operating procedure for white papers (expert consensus based clinical guidance) Open
Promoting the highest quality, evidence-based research across Europe is a priority of the European Stroke Organisation (ESO). The ESO Guideline Board communicate and promote evidence-based recommendations for clinical practice through thei…
View article: From fragmented to integrated healthcare managing hypertension post-stroke: a qualitative study
From fragmented to integrated healthcare managing hypertension post-stroke: a qualitative study Open
Introduction As stroke incidence rises with an aging population, hypertension remains a critical modifiable risk factor for both primary and secondary stroke prevention. Effective management of hypertension post-stroke requires a shift fro…
View article: SaeboGlove™ Therapy For Upper Limb Disability And Severe Hand Impairment after Stroke (SUSHI); a Randomised, Multicentre, Parallel-Group, Controlled Trial with Blinded Outcome Assessment and Economic Evaluation
SaeboGlove™ Therapy For Upper Limb Disability And Severe Hand Impairment after Stroke (SUSHI); a Randomised, Multicentre, Parallel-Group, Controlled Trial with Blinded Outcome Assessment and Economic Evaluation Open
View article: Social cognitive function in stroke survivors: A scoping review
Social cognitive function in stroke survivors: A scoping review Open
Social cognition after stroke research has mainly addressed emotion recognition, theory of mind, and empathy, with limited attention to other aspects. Although social cognition impairments were common, no studies have specifically targeted…
View article: Developing treatments for cerebral small vessel disease: a scoping review of licensed interventions for potential repurposing
Developing treatments for cerebral small vessel disease: a scoping review of licensed interventions for potential repurposing Open
Background Cerebral small vessel disease (cSVD) is a progressive neurovascular-degenerative condition without specific treatment that causes lacunar stroke, most intracerebral haemorrhage, vascular cognitive impairment (VCI) and several ne…
View article: Mechanisms underlying neurocognitive dysfunction following critical illness: a systematic review
Mechanisms underlying neurocognitive dysfunction following critical illness: a systematic review Open
Summary Introduction Cognitive impairment is a significant healthcare problem globally and its prevalence is projected to affect over 150 million people worldwide. Survivors of critical illness are impacted frequently by long‐term neurocog…
View article: Heart–brain microvascular MRI study: protocol for a multicentre, observational, cohort study in the UK assessing associations between small vessel disease of the heart and brain
Heart–brain microvascular MRI study: protocol for a multicentre, observational, cohort study in the UK assessing associations between small vessel disease of the heart and brain Open
Introduction Ischaemic heart disease (IHD) and cerebrovascular disease are leading causes of morbidity and mortality worldwide. Cerebral small vessel disease (CSVD) is a leading cause of dementia and stroke. While coronary small vessel dis…
View article: Associations and interactions between premorbid cognitive health, apolipoprotein e4 genotype, and incident Alzheimer’s disease in UK Biobank (N=252,340)
Associations and interactions between premorbid cognitive health, apolipoprotein e4 genotype, and incident Alzheimer’s disease in UK Biobank (N=252,340) Open
Background: It is unclear to what extent genetic risk offsets the protective effects of better premorbid cognitive health, on risk of Alzheimer’s disease (AD). To address this, we tested for associations between measures of premorbid cogni…
View article: Data-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool
Data-Driven Cutoff Selection for the Patient Health Questionnaire-9 Depression Screening Tool Open
Importance Test accuracy studies often use small datasets to simultaneously select an optimal cutoff score that maximizes test accuracy and generate accuracy estimates. Objective To evaluate the degree to which using data-driven methods to…
View article: The factor structure of the Patient Health Questionnaire-9 in stroke: A comparison with a non-stroke population
The factor structure of the Patient Health Questionnaire-9 in stroke: A comparison with a non-stroke population Open