Explanipedia

STEREOTACTIC ABLATIVE RADIOTHERAPY FOR HEPATOCELLULAR CARCINOMA WITH PENCIL BEAM SCANNING PROTON THERAPY: INITIAL RESULTS FROM A PROSPECTIVE PHASE II TRIAL Open

William G. Rule, Terence T. Sio, Molly M. Voss, Nicole Thomas, Mitesh J. Borad , et al. · 2025

Stereotactic ablative radiotherapy for hepatocellular carcinoma with pencil beam scanning proton therapy: Initial results from a prospective phase II trial Open

Jonathan B. Ashman, R.S. Bhangoo, Kenneth W. Merrell, William G. Rule, Terence T. Sio , et al. · 2025

Fine-Tuning Open-Source Large Language Models to Improve Their Performance on Radiation Oncology Tasks: A Feasibility Study to Investigate Their Potential Clinical Applications in Radiation Oncology Open

P. Wang, Zhengliang Liu, Yiwei Li, Jason Holmes, Peng Shu , et al. · 2025

Background: The radiation oncology clinical practice involves many steps relying on the dynamic interplay of abundant text data. Large language models have displayed remarkable capabilities in processing complex text information. But their…

FINE-TUNING LARGE LANGUAGE MODELS FOR RADIATION ONCOLOGY, A HIGHLY SPECIALIZED HEALTHCARE DOMAIN Open

Zhengliang Liu, P. Wang, Yiwei Li, Jason Holmes, Peng Shu , et al. · 2024

Noisy probing dose facilitated dose prediction for pencil beam scanning proton therapy: physics enhances generalizability Open

Lian Zhang, Jason Holmes, Zhengliang Liu, Hongying Feng, Terence T. Sio , et al. · 2023

Purpose: Prior AI-based dose prediction studies in photon and proton therapy often neglect underlying physics, limiting their generalizability to handle outlier clinical cases, especially for pencil beam scanning proton therapy (PBSPT). Ou…

RADT-25. IMPACT OF 18F-DOPA PET ON RADIATION TREATMENT PLANNING FROM PHASE II STUDY OF SHORT COURSE HYPOFRACTIONATED PROTON BEAM THERAPY FOR ELDERLY PATIENTS WITH GLIOBLASTOMA Open

Brady Laughlin, Deanna Pafundi, Matthew Buras, Jonathan B. Ashman, Bernard R. Bendok , et al. · 2023

PURPOSE 18F-DOPA is sensitive/specific for identifying areas of biologically aggressive disease for glioblastoma. We report the impact of 18F-DOPA on radiation treatment planning from a phase II study. METHODS Gross target volume (GTV) was…

Patient-Reported Adverse Effects in 15-Fraction Pancreatic Cancer Radiation Therapy Open

Yasamin Sharifzadeh, H.J. Gunn, Christopher L. Hallemeier, W.S. Harmsen, Satomi Shiraishi , et al. · 2023

Quality and Safety Considerations in Image Guided Radiation Therapy: An ASTRO Safety White Paper Update Open

X. Sharon Qi, Kevin Albuquerque, S. Bailey, Sarah Dawes, Rojano Kashani , et al. · 2023

Beam mask and sliding window‐facilitated deep learning‐based accurate and efficient dose prediction for pencil beam scanning proton therapy Open

Lian Zhang, Jason Holmes, Zhengliang Liu, Sujay A. Vora, Terence T. Sio , et al. · 2023

Background Accurate and efficient dose calculation is essential for on‐line adaptive planning in proton therapy. Deep learning (DL) has shown promising dose prediction results in photon therapy. However, there is a scarcity of DL‐based dos…

RadOnc-GPT: A Large Language Model for Radiation Oncology Open

Zhengliang Liu, P. Wang, Yiwei Li, Jason Holmes, Peng Shu , et al. · 2023

This paper presents RadOnc-GPT, a large language model specialized for radiation oncology through advanced tuning methods. RadOnc-GPT was finetuned on a large dataset of radiation oncology patient records from the Mayo Clinic in Arizona. T…

Table of Contents Open

Mohammed Ameen, Fiona Lynch, Muriel Sadlier, Alex Balfour, Jodie Raffi , et al. · 2023

Evaluating large language models on a highly-specialized topic, radiation oncology physics Open

Jason Holmes, Zhengliang Liu, Lian Zhang, Yuzhen Ding, Terence T. Sio , et al. · 2023

Purpose We present the first study to investigate Large Language Models (LLMs) in answering radiation oncology physics questions. Because popular exams like AP Physics, LSAT, and GRE have large test-taker populations and ample test prepara…

Anticoagulant therapy in <span>COVID</span>‐19: A narrative review Open

Zeinab Mohseni Afshar, Ali Tavakoli Pirzaman, Rezvan Hosseinzadeh, Arefeh Babazadeh, Mohamad Ali Taghizadeh Moghadam , et al. · 2023

Coronavirus disease 2019 (COVID‐19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can manifest itself in several ways, including coagulopathy and thrombosis. These complications can be the first and sometimes…

Treatment of sclerotic chronic graft-versus-host disease with injections of hyaluronidase Open

Tiffany Cheng, Ryan Colakovic, David R. Pearson, Terence T. Sio, Lori Fiessinger · 2023

Deep‐learning based fast and accurate 3D CT deformable image registration in lung cancer Open

Yuzhen Ding, Hongying Feng, Yunze Yang, Jason Holmes, Zhengliang Liu , et al. · 2023

Background Deformable Image Registration (DIR) is an essential technique required in many applications of radiation oncology. However, conventional DIR approaches typically take several minutes to register one pair of 3D CT images and the …

Five-year follow-up after stereotactic body radiotherapy for medically inoperable early-stage non-small cell lung cancer: a multicenter study Open

Yanling Guo, Yaoyao Zhu, Ran Zhang, Shuangyan Yang, Lucyna Kępka , et al. · 2023

From our retrospective analysis with long-term follow-up in Chinese population, SBRT achieved high rate of local control (LC) and low toxicity in patients with early-stage NSCLC. This study offered robust long-term outcome data of SBRT in …

Evaluating Large Language Models on a Highly-specialized Topic, Radiation Oncology Physics Open

Jason Holmes, Zhengliang Liu, Lian Zhang, Yuzhen Ding, Terence T. Sio , et al. · 2023

We present the first study to investigate Large Language Models (LLMs) in answering radiation oncology physics questions. Because popular exams like AP Physics, LSAT, and GRE have large test-taker populations and ample test preparation res…

Myocarditis and Pericarditis Following the SARS-CoV-2 Infection and COVID-19 Vaccination Open

Zeinab Mohseni Afshar, Jackson J. Liang, Mohammad Amin Habib, Mohamad Ali Taghizadeh Moghadam, Arefeh Babazadeh , et al. · 2023

Cardiac complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been well-identified since the beginning of the current coronavirus disease 2019 (COVID-19) pandemic. Such conditions can occur of various…

SARS-CoV-2 Omicron (B.1.1.529) Variant: A Challenge with COVID-19 Open

Zeinab Mohseni Afshar, Ali Tavakoli Pirzaman, Bardia Karim, Shiva Rahimipour Anaraki, Rezvan Hosseinzadeh , et al. · 2023

Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there have been multiple peaks of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus virus 2) infection, mainly due to the emergence of new variants, each …

Capillary Leak Syndrome after SARS-CoV-2 Infection and COVID-19 Vaccines: A Comparative Review Open

Zeinab Mohseni Afshar, Hossein Nazari Rostami, Ali Tavakoli Pirzaman, Rezvan Hosseinzadeh, Arefeh Babazadeh , et al. · 2023

Systemic capillary leak syndrome (SCLS) is an uncommon, potentially life-threatening disorder defined as recurrent attacks of pseudo-shock. This syndrome occurs due to the disruption of endothelial cells, which leads to increased vascular …

Clinical Outcomes of Stereotactic Radiosurgery-Related Radiation Necrosis in Patients with Intracranial Metastasis from Melanoma Open

Holly M Thomson, Shannon P. Fortin Ensign, Victoria S. Edmonds, Akanksha Sharma, Richard Butterfield , et al. · 2023

Background: Radiation necrosis (RN) is a clinically relevant complication of stereotactic radiosurgery (SRS) for intracranial metastasis (ICM) treatments. Radiation necrosis development is variable following SRS. It remains unclear if risk…

A review of the potential neurological adverse events of COVID-19 vaccines Open

Zeinab Mohseni Afshar, Akanksha Sharma, Arefeh Babazadeh, Ali Alizadeh-Khatir, Terence T. Sio , et al. · 2022

SARS-CoV-2 Omicron (B.1.1.529) Variant: A Challenge with Covid-19 Open

Zeinab Mohseni Afshar, Ali Tavakoli Pirzaman, Bardia Karim, Rezvan Hosseinzadeh, Arefeh Babazadeh , et al. · 2022

Since the beginning of the coronavirus disease 2019 (Covid-19) pandemic, there have been multiple peaks of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus virus 2) infection, mainly due to the emergence of new variants, each …

Do we miss rare adverse events induced by COVID-19 vaccination? Open

Zeinab Mohseni Afshar, Ali Tavakoli Pirzaman, Jackson J. Liang, Akanksha Sharma, Marzieh Pirzadeh , et al. · 2022

Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused many complications, the invention of coronavirus disease 2019 (COVID-19) vaccines has also brought about several adverse events, from common side ef…

Excellent clinical outcomes can be achieved with neoadjuvant chemoradiation and orthotopic liver transplantation for unresectable cholangiocarcinoma: support for the need of an international transplant protocol Open

Brady Laughlin, Jonathan B. Ashman, William G. Rule, Nathan Y. Yu, Terence T. Sio · 2022

Excellent clinical outcomes can be achieved with neoadjuvant chemoradiation and orthotopic liver transplantation for unresectable cholangiocarcinoma: support for the need of an international transplant protocol

International consensus on radiotherapy in metastatic non-small cell lung cancer Open

Zhengfei Zhu, Jianjiao Ni, Xu‐Wei Cai, Shengfa Su, Hongqing Zhuang , et al. · 2022

In the modern era, radiotherapy serves not only as a palliative tool in metastatic NSCLC, but also plays active roles in patients with oligo-focal disease, CNS metastasis and receiving ICIs.

Author Correction: The effect of propolis on 5-fluorouracil-induced cardiac toxicity in rats Open

Mohammad Barary, Rezvan Hosseinzadeh, Sohrab Kazemi, Jackson J. Liang, Razieh Mansoori , et al. · 2022

Fulminant hepatitis following <span>COVID</span> ‐19 vaccination: A case report Open

Mohammad Barary, Athena Sharifi‐Razavi, Nasser Rakhshani, Terence T. Sio, Soheil Ebrahimpour , et al. · 2022

The common side effects of COVID‐19 vaccination were mostly self‐restricted local reactions that quickly resolved. Nevertheless, rare autoimmune hepatitis cases have been reported in some vaccinated with mRNA COVID‐19 vaccines. This articl…

The reemergence of monkeypox as a new potential health challenge: A critical review Open

Zeinab Mohseni Afshar, Hossein Nazari Rostami, Rezvan Hosseinzadeh, Alireza Janbakhsh, Ali Tavakoli Pirzaman , et al. · 2022

Human monkeypox is a zoonotic Orthopoxvirus resembling smallpox in clinical course, making it difficult to distinguish it from smallpox and varicella. Laboratory diagnostics are critical components of illness identification and surveillanc…

Immune checkpoint inhibitor (ICI)-based treatment beyond progression with prior immunotherapy in patients with stage IV non-small cell lung cancer: a retrospective study Open

Tian Tian, Min Yu, Yang Yu, Ke Wang, Panwen Tian , et al. · 2022

While the ORR in patients with advanced NSCLC receiving ICI-based TBP with prior immunotherapy was limited, the DCR was relatively high in our study which is encouraging. ICI-based treatment strategy may be a reasonable option for patients…

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