Terence T. W. Wong
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View article: Lepidium virginicum Water-Soluble Chlorophyll-Binding Protein with Chlorophyll A as a Novel Contrast Agent for Photoacoustic Imaging
Lepidium virginicum Water-Soluble Chlorophyll-Binding Protein with Chlorophyll A as a Novel Contrast Agent for Photoacoustic Imaging Open
Photoacoustic (PA) imaging (PAI) holds great promise for non-invasive biomedical diagnostics. However, the efficacy of current contrast agents is often limited by photobleaching, toxicity, and complex synthesis processes. In this study, we…
View article: Autofluorescence Imaging and Virtual Histological Staining of Human Prostate Sections for Cancer Diagnosis
Autofluorescence Imaging and Virtual Histological Staining of Human Prostate Sections for Cancer Diagnosis Open
Autofluorescence imaging with virtual histological staining has shown promising potential to improve the efficiency of postoperative histopathology workflow. Here, a widefield deep‐ultraviolet light‐emitting diode‐based imaging system to g…
View article: Simultaneous Ultraviolet Photoacoustic and Auto‐Fluorescence Microscopy for High‐Contrast Histological Imaging
Simultaneous Ultraviolet Photoacoustic and Auto‐Fluorescence Microscopy for High‐Contrast Histological Imaging Open
Ultraviolet (UV) photoacoustic microscopy has attracted lots of attention since it can provide histological images for disease diagnosis without any tissue processing or staining, holding great potential for rapid histopathology in hospita…
View article: Rapid full-color serial sectioning tomography with speckle illumination and ultraviolet excitation
Rapid full-color serial sectioning tomography with speckle illumination and ultraviolet excitation Open
Three-dimensional (3D) high-resolution large-volume imaging has remained a challenge. Translational rapid ultraviolet-excited sectioning tomography (TRUST) achieves rapid and cost-effective whole-organ subcellular imaging through iterative…
View article: Deep Learning‐Enhanced Fiber‐Coupled Laser Diode‐Based Photoacoustic Microscopy for High‐Resolution Microvasculature Imaging
Deep Learning‐Enhanced Fiber‐Coupled Laser Diode‐Based Photoacoustic Microscopy for High‐Resolution Microvasculature Imaging Open
Blood vessel imaging provides crucial information for physiological monitoring and disease diagnosis. Optical‐resolution photoacoustic microscopy (PAM) is gaining intense attention in high‐resolution in vivo imaging of blood vessels. Howev…
View article: Tri-modality in vivo imaging for tumor detection with combined ultrasound, photoacoustic, and photoacoustic elastography
Tri-modality in vivo imaging for tumor detection with combined ultrasound, photoacoustic, and photoacoustic elastography Open
A comprehensive understanding of a tumor is required for accurate diagnosis and effective treatment. However, currently, there is no single imaging modality that can provide sufficient information. Photoacoustic (PA) imaging is a hybrid im…
View article: Lung Cancer Diagnosis on Virtual Histologically Stained Tissue Using Weakly Supervised Learning
Lung Cancer Diagnosis on Virtual Histologically Stained Tissue Using Weakly Supervised Learning Open
Lung adenocarcinoma (LUAD) is the most common primary lung cancer and accounts for 40% of all lung cancer cases. The current gold standard for lung cancer analysis is based on the pathologists' interpretation of hematoxylin and eosin (H&E)…
View article: Exceeding the limit for microscopic image translation with a deep learning-based unified framework
Exceeding the limit for microscopic image translation with a deep learning-based unified framework Open
Deep learning algorithms have been widely used in microscopic image translation. The corresponding data-driven models can be trained by supervised or unsupervised learning depending on the availability of paired data. However, general case…
View article: Frontispiz: Co‐aggregation as A Simple Strategy for Preparing Fluorogenic Tetrazine Probes with On‐Demand Fluorogen Selection
Frontispiz: Co‐aggregation as A Simple Strategy for Preparing Fluorogenic Tetrazine Probes with On‐Demand Fluorogen Selection Open
Aggregation-Induced Emission. In their Research Article (e202313930), Terence T. W. Wong, Xuewen He, Ben Zhong Tang et al. demonstrate how co-aggregation of tetrazine molecules and fluorophores serves as a simple, fast, and convenient stra…
View article: Frontispiece: Co‐aggregation as A Simple Strategy for Preparing Fluorogenic Tetrazine Probes with On‐Demand Fluorogen Selection
Frontispiece: Co‐aggregation as A Simple Strategy for Preparing Fluorogenic Tetrazine Probes with On‐Demand Fluorogen Selection Open
Aggregation-Induced Emission. In their Research Article (e202313930), Terence T. W. Wong, Xuewen He, Ben Zhong Tang et al. demonstrate how co-aggregation of tetrazine molecules and fluorophores serves as a simple, fast, and convenient stra…
View article: Deep learning-assisted low-cost autofluorescence microscopy for rapid slide-free imaging with virtual histological staining
Deep learning-assisted low-cost autofluorescence microscopy for rapid slide-free imaging with virtual histological staining Open
Slide-free imaging techniques have shown great promise in improving the histological workflow. For example, computational high-throughput autofluorescence microscopy by pattern illumination (CHAMP) has achieved high resolution with a long …
View article: Deep learning-assisted smartphone-based quantitative microscopy for label-free peripheral blood smear analysis
Deep learning-assisted smartphone-based quantitative microscopy for label-free peripheral blood smear analysis Open
Hematologists evaluate alterations in blood cell enumeration and morphology to confirm peripheral blood smear findings through manual microscopic examination. However, routine peripheral blood smear analysis is both time-consuming and labo…
View article: Acoustic-feedback wavefront-adapted photoacoustic microscopy
Acoustic-feedback wavefront-adapted photoacoustic microscopy Open
Optical microscopy is indispensable to biomedical research and clinical investigations. As all molecules absorb light, optical-resolution photoacoustic microscopy (PAM) is an important tool to image molecules at high resolution without lab…
View article: Label-free and non-destructive histology of unprocessed biological tissues with ultraviolet single-plane illumination microscopy
Label-free and non-destructive histology of unprocessed biological tissues with ultraviolet single-plane illumination microscopy Open
Histopathology has remained the gold standard for surgical margin assessment for decades. However, routine pathological examination based on formalin-fixed and paraffin-embedded (FFPE) tissues is laborious and time-consuming, failing to gu…
View article: High-throughput, nondestructive, and low-cost histological imaging with deep-learning-assisted UV microscopy
High-throughput, nondestructive, and low-cost histological imaging with deep-learning-assisted UV microscopy Open
Pathological examination is essential for cancer diagnosis. Frozen sectioning has been the gold standard for intraoperative tissue assessment, which, however, is hampered by its laborious processing steps and often provides inadequate tiss…
View article: Review of low-cost light sources and miniaturized designs in photoacoustic microscopy
Review of low-cost light sources and miniaturized designs in photoacoustic microscopy Open
The review highlights the potential of these advancements to revolutionize PAM technology, making it more accessible and practical for various applications in preclinical studies, clinical practice, and long-term monitoring.
View article: Deep Learning Enables Rapid Whole-Organ Histological Imaging with Ultraviolet-Excited Sectioning Tomography
Deep Learning Enables Rapid Whole-Organ Histological Imaging with Ultraviolet-Excited Sectioning Tomography Open
Three-dimensional (3D) histopathology involves the microscopic examination of a specimen, which plays a vital role in studying tissue's 3D structures and the signs of diseases. However, acquiring high-quality histological images of a whole…
View article: Co-aggregation as an Exceptionally Simple Platform to Prepare Fluorogenic Tetrazine Probes with On-Demand Fluorophore Selection
Co-aggregation as an Exceptionally Simple Platform to Prepare Fluorogenic Tetrazine Probes with On-Demand Fluorophore Selection Open
Life science has progressed with applications of fluorescence probes — fluorophores linked to functional units responsive to biological events. To meet the varied demands across experiments, simple organic reactions to connect fluorophores…
View article: Automated whole-organ histological imaging assisted with ultraviolet-excited sectioning tomography and deep learning
Automated whole-organ histological imaging assisted with ultraviolet-excited sectioning tomography and deep learning Open
Three-dimensional (3D) histopathology involves the microscopic examination of a specimen, which plays a vital role in studying tissue’s 3D structures and the signs of diseases. However, acquiring high-quality histological images of a whole…
View article: Label-free differential imaging of cellular components in mouse brain tissue by wide-band photoacoustic microscopy
Label-free differential imaging of cellular components in mouse brain tissue by wide-band photoacoustic microscopy Open
Mapping diverse cellular components with high spatial resolution is important to interrogate biological systems and study disease pathogenesis. Conventional optical imaging techniques for mapping biomolecular profiles with differential sta…
View article: Deep Learning Assisted Smartphone-based Quantitative Microscopy for Label-free Hematological Analysis
Deep Learning Assisted Smartphone-based Quantitative Microscopy for Label-free Hematological Analysis Open
Hematologists evaluate alterations in blood cell enumeration and morphology to confirm the peripheral blood smear findings through manual microscopic examination. However, routine peripheral blood smear analysis is both time-consuming and …
View article: Label-free and non-destructive pathology of human lung adenocarcinomas with ultraviolet single-plane illumination microscopy
Label-free and non-destructive pathology of human lung adenocarcinomas with ultraviolet single-plane illumination microscopy Open
Lung cancer is one of the leading causes of cancer death worldwide. The diagnosis of lung cancer based on the analysis of formalin-fixed and paraffin-embedded (FFPE) tissues is laborious and time-consuming, failing to guide surgeons intrao…
View article: Translational rapid ultraviolet-excited sectioning tomography for whole-organ multicolor imaging with real-time molecular staining
Translational rapid ultraviolet-excited sectioning tomography for whole-organ multicolor imaging with real-time molecular staining Open
Rapid multicolor three-dimensional (3D) imaging for centimeter-scale specimens with subcellular resolution remains a challenging but captivating scientific pursuit. Here, we present a fast, cost-effective, and robust multicolor whole-organ…
View article: Author response: Translational rapid ultraviolet-excited sectioning tomography for whole-organ multicolor imaging with real-time molecular staining
Author response: Translational rapid ultraviolet-excited sectioning tomography for whole-organ multicolor imaging with real-time molecular staining Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract Rapid multicolor three-dimensional (…
View article: A Weakly Supervised Deep Generative Model for Complex Image Restoration and Style Transformation
A Weakly Supervised Deep Generative Model for Complex Image Restoration and Style Transformation Open
The datasets for transforming autofluorescence images to the histochemically stained images were acquired from a human breast biopsy tissue and a human liver cancer tissue. Tissues of breast cancer and liver cancer were extracted surgicall…
View article: A Weakly Supervised Deep Generative Model for Complex Image Restoration and Style Transformation
A Weakly Supervised Deep Generative Model for Complex Image Restoration and Style Transformation Open
The datasets for transforming autofluorescence images to the histochemically stained images were acquired from a human breast biopsy tissue and a human liver cancer tissue. Tissues of breast cancer and liver cancer were extracted surgicall…
View article: Low-cost high-resolution photoacoustic microscopy of blood oxygenation with two laser diodes
Low-cost high-resolution photoacoustic microscopy of blood oxygenation with two laser diodes Open
Optical-resolution photoacoustic microscopy (OR-PAM) has been widely used for imaging blood vessel and oxygen saturation of hemoglobin (sO 2 ), providing high-resolution functional images of living animals in vivo . However, most of them r…
View article: High-Speed Ultraviolet Photoacoustic Microscopy for Histological Imaging with Virtual-Staining assisted by Deep Learning
High-Speed Ultraviolet Photoacoustic Microscopy for Histological Imaging with Virtual-Staining assisted by Deep Learning Open
Surgical margin analysis (SMA), an essential procedure to confirm the complete excision of cancerous tissue in tumor resection surgery, requires intraoperative diagnostic tools to avoid repeated surgeries due to a positive surgical margin.…
View article: Rapid slide-free and non-destructive histological imaging using wide-field optical-sectioning microscopy
Rapid slide-free and non-destructive histological imaging using wide-field optical-sectioning microscopy Open
Histopathology based on formalin-fixed and paraffin-embedded tissues has long been the gold standard for surgical margin assessment (SMA). However, routine pathological practice is lengthy and laborious, failing to guide surgeons intraoper…