Teresa Infante
YOU?
Author Swipe
View article: DNA hypermethylation of MED1 and MED23 as early diagnostic biomarkers for unsolved issues in atrial fibrillation
DNA hypermethylation of MED1 and MED23 as early diagnostic biomarkers for unsolved issues in atrial fibrillation Open
For the first time, we showed that DNA methylation changes are associated with regulation of MED complex subunits in early diagnosis of AF patients. Clinically, MED1 and MED23 hypermethylation showed a diagnostic value not inferior to circ…
View article: <scp> <i>CDK5R1</i> </scp> , <scp> <i>GSE1</i> </scp> , <scp> <i>HSPG2</i> </scp> and <scp> <i>WDFY3</i> </scp> as indirect epigenetic‐sensitive genes in atrial fibrillation
<span> <i>CDK5R1</i> </span> , <span> <i>GSE1</i> </span> , <span> <i>HSPG2</i> </span> and <span> <i>WDFY3</i> </span> as indirect epigenetic‐sensitive genes in atrial fibrillation Open
Background Although mounting evidence supports that aberrant DNA methylation occurs in the hearts of patients with atrial fibrillation (AF), noninvasive epigenetic characterization of AF has not yet been defined. Methods We investigated DN…
View article: Integrated epigenomic and network analysis identifies novel DNA methylation signature in atrial fibrillation
Integrated epigenomic and network analysis identifies novel DNA methylation signature in atrial fibrillation Open
Background CD4+ T cells are associated with atrial fibrillation (AF) pathogenesis but mechanistic insights as well as epigenetic phenomena underlying the onset and progression of AF are not fully understood. Purpose To identify differentia…
View article: <i>ABCA1, TCF7, NFATC1, PRKCZ,</i> and <i>PDGFA</i> DNA methylation as potential epigenetic-sensitive targets in acute coronary syndrome <i>via</i> network analysis
<i>ABCA1, TCF7, NFATC1, PRKCZ,</i> and <i>PDGFA</i> DNA methylation as potential epigenetic-sensitive targets in acute coronary syndrome <i>via</i> network analysis Open
Acute coronary syndrome (ACS) is the most severe clinical manifestation of coronary heart disease.We performed an epigenome-wide analysis of circulating CD4+ and CD8+ T cells isolated from ACS patients and healthy sub…
View article: <i>ABCA1, TCF7, NFATC1, PRKCZ,</i> and <i>PDGFA</i> DNA methylation as potential epigenetic-sensitive targets in acute coronary syndrome <i>via</i> network analysis
<i>ABCA1, TCF7, NFATC1, PRKCZ,</i> and <i>PDGFA</i> DNA methylation as potential epigenetic-sensitive targets in acute coronary syndrome <i>via</i> network analysis Open
Acute coronary syndrome (ACS) is the most severe clinical manifestation of coronary heart disease. We performed an epigenome-wide analysis of circulating CD4+ and CD8+ T cells isolated from ACS patients and healthy su…
View article: Integrated analysis of DNA methylation profile in HLA-G gene and imaging in coronary heart disease
Integrated analysis of DNA methylation profile in HLA-G gene and imaging in coronary heart disease Open
Aims Immune endothelial inflammation, underlie coronary heart disease (CHD) related phenotypes, could provide new insight into the pathobiology of the disease. We investigated DNA methylation level of the unique CpG island of HLA-G gene in…
View article: DNA methylation profiling of CD04+/CD08+ T cells reveals pathogenic mechanisms in increasing hyperglycemia: PIRAMIDE pilot study
DNA methylation profiling of CD04+/CD08+ T cells reveals pathogenic mechanisms in increasing hyperglycemia: PIRAMIDE pilot study Open
SPARC hypomethylation in CD08+ T cells may be a useful biomarker of vascular complications in Pre-Diab with a possible role for primary prevention warranting further multicenter clinical trials to validate our findings.
View article: Integrated analysis of DNA methylation profile of HLA-G gene and imaging in coronary heart disease: Pilot study
Integrated analysis of DNA methylation profile of HLA-G gene and imaging in coronary heart disease: Pilot study Open
Reduced levels of circulating HLA-G molecules could derive from epigenetic marks. Epigenetics phenomena induce hypomethylation of specific regions into 5'UTR-CpG island of HLA-G gene in CHD patients with obstructive non critical stenosis v…
View article: Differential DNA Methylation Encodes Proliferation and Senescence Programs in Human Adipose-Derived Mesenchymal Stem Cells
Differential DNA Methylation Encodes Proliferation and Senescence Programs in Human Adipose-Derived Mesenchymal Stem Cells Open
Adult adipose tissue-derived mesenchymal stem cells (ASCs) constitute a vital population of multipotent cells capable of differentiating into numerous end-organ phenotypes. However, scientific and translational endeavors to harness the reg…
View article: Early targeted DNA methylation profiling of CD04+/CD08+ T cells reveals pathogenic mechanisms in different stages of impaired glucose homeostasis Cardiovascular Diabetology
Early targeted DNA methylation profiling of CD04+/CD08+ T cells reveals pathogenic mechanisms in different stages of impaired glucose homeostasis Cardiovascular Diabetology Open
Background: Despite current intensive treatments, hyperglycemic patients have an unfavorable prognosis due to severe CHD and development of complications. The interplay between hyperglycemia and systemic inflammation can modify patterns of…
View article: Network Medicine: A Clinical Approach for Precision Medicine and Personalized Therapy in Coronary Heart Disease
Network Medicine: A Clinical Approach for Precision Medicine and Personalized Therapy in Coronary Heart Disease Open
Early identification of coronary atherosclerotic pathogenic mechanisms is useful for predicting the risk of coronary heart disease (CHD) and future cardiac events. Epigenome changes may clarify a significant fraction of this "missing hered…
View article: Evidence of association of circulating epigenetic-sensitive biomarkers with suspected coronary heart disease evaluated by Cardiac Computed Tomography
Evidence of association of circulating epigenetic-sensitive biomarkers with suspected coronary heart disease evaluated by Cardiac Computed Tomography Open
Circulating biomarkers available in clinical practice do not allow to stratify patients with coronary heart disease (CHD) prior the onset of a clinically relevant event. We evaluated the methylation status of specific genomic segments and …
View article: Image Quality and Dose Reduction by Dual Source Computed Tomography Coronary Angiography: Protocol Comparison
Image Quality and Dose Reduction by Dual Source Computed Tomography Coronary Angiography: Protocol Comparison Open
Purpose: To compare image quality and radiation dose among different protocols in patients who underwent a 128-slice dual source computed tomography coronary angiography (DSCT-CTCA). Methods: Ninety patients were retrospectively grouped ac…
View article: A case of coronary arterio-venous fistula: the role of cardiac computed tomography
A case of coronary arterio-venous fistula: the role of cardiac computed tomography Open
Coronary artery fistulas (CAFs) are often incidental findings in patients undergoing conventional coronary angiography (CAG). CAFs represent a congenital or acquired abnormal vascular communication of coronary arteries with cardiac chamber…
View article: In Vivo and In Vitro Analysis in Coronary Artery Disease Related to Type 2 Diabetes
In Vivo and In Vitro Analysis in Coronary Artery Disease Related to Type 2 Diabetes Open
AimThe leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (DM) is coronary artery disease (CAD), a condition often asymptomatic but severe in these patients. Although glucose metabolism impairment and oxidat…
View article: Radiogenomic Analysis of Oncological Data: A Technical Survey
Radiogenomic Analysis of Oncological Data: A Technical Survey Open
In the last few years, biomedical research has been boosted by the technological development of analytical instrumentation generating a large volume of data. Such information has increased in complexity from basic (i.e., blood samples) to …
View article: SDN Biobank: Bioresource of Human Samples Associated with Functional and/or Morphological Bioimaging Results for the Study of Oncological, Cardiological, Neurological, and Metabolic Diseases
SDN Biobank: Bioresource of Human Samples Associated with Functional and/or Morphological Bioimaging Results for the Study of Oncological, Cardiological, Neurological, and Metabolic Diseases Open
SDN Biobank is a not-for-profit service unit. Initially, it was established by the IRCCS SDN in 2012 as a collection of serum and plasma samples from patients who underwent advanced bioimaging exams, such as those performed with Positron E…
View article: An integrated approach to coronary heart disease diagnosis and clinical management.
An integrated approach to coronary heart disease diagnosis and clinical management. Open
The major issue in coronary heart disease (CHD) diagnosis and management is that symptoms onset in an advanced state of disease. Despite the availability of several clinical risk scores, the prediction of cardiovascular events is lacking, …
View article: Coronary artery aneurysms detected by computed tomography coronary angiography
Coronary artery aneurysms detected by computed tomography coronary angiography Open
CTCA has led to a non-invasive estimation of CAAs prevalence and characterization of aneurysmal features and coronary anatomy. Overcoming ICA limitations, CTCA has provided a fine analysis of the aneurysms, also in presence of intraluminal…
View article: Polycomb YY1 is a critical interface between epigenetic code and miRNA machinery after exposure to hypoxia in malignancy
Polycomb YY1 is a critical interface between epigenetic code and miRNA machinery after exposure to hypoxia in malignancy Open