Teresa Rampino
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View article: Current Usage of Extracorporeal Photopheresis in Solid Organ Transplantations in Europe: A Narrative Review
Current Usage of Extracorporeal Photopheresis in Solid Organ Transplantations in Europe: A Narrative Review Open
Solid organ transplantation (SOT) faces significant challenges in managing allograft rejection, with current immunosuppressive therapies often associated with substantial adverse effects. Extracorporeal photopheresis (ECP) has emerged as a…
View article: #3520 Gene expression profiles of PBMCs in kidney vs. lung recipients prior to extracorporeal photopheresis: similarities and differences
#3520 Gene expression profiles of PBMCs in kidney vs. lung recipients prior to extracorporeal photopheresis: similarities and differences Open
Background and Aims Chronic allograft rejection of the kidney (CKR) and lung transplant (CLAD) represent major causes of mortality and graft loss, with limited therapeutic options currently available. Several centers are now adopting extra…
View article: #3371 Hypothermic oxygenated perfusion of marginal kidneys with extracellular vesicles from mesenchymal stromal cells: a proteomic analysis
#3371 Hypothermic oxygenated perfusion of marginal kidneys with extracellular vesicles from mesenchymal stromal cells: a proteomic analysis Open
Background and Aims Hypothermic oxygenated perfusion (HOPE) is a technique for preserving organs by circulating oxygenated solution at 4°C throughout the renal vasculature to deliver oxygen and nutrients. We have previously found that extr…
View article: #2827 Association of complement deposition with clinical phenotype in lupus nephropathies (LN)
#2827 Association of complement deposition with clinical phenotype in lupus nephropathies (LN) Open
Background and Aims Complement system activation is a well-established pathogenic mechanism contributing to lupus nephritis (LN). C3, C4/C1q staining is an easy-to-perform method for analyzing renal biopsies. Our study aimed to determine w…
View article: #3701 Genetic insights delCFHR3-1 linked to <i>de novo</i> thrombotic microangiopathy in kidney transplant rfecipients
#3701 Genetic insights delCFHR3-1 linked to <i>de novo</i> thrombotic microangiopathy in kidney transplant rfecipients Open
Background and Aims The complement system's overactivation typically occurs during transplantation and in the post-transplant phase. Indeed, donor and recipient characteristics, various drugs (mTOR inhibitors, CNIs), viral infections and i…
View article: #2350 PCSK9 inhibitors protect kidney from ischemia-reperfusion injury reducing oxidative stress and enhancing tissue resistance: a metabolomics analysis
#2350 PCSK9 inhibitors protect kidney from ischemia-reperfusion injury reducing oxidative stress and enhancing tissue resistance: a metabolomics analysis Open
Background and Aims The shortage of kidneys and the growing number of patients requiring a transplant pose a major challenge. Research efforts are focused on developing new therapies to improve both the quantity and quality of transplantab…
View article: #3491 <b> Engineered ATP-loaded extracellular vesicles derived from mesenchymal stem cells: a novel strategy to counteract cell ATP depletion in an <i>in vitro</i> model </b>
#3491 <b> Engineered ATP-loaded extracellular vesicles derived from mesenchymal stem cells: a novel strategy to counteract cell ATP depletion in an <i>in vitro</i> model </b> Open
Background and Aims The use of ATP-loaded liposomes has shown promise in mitigating ischemic damage in various tissues. However, kidney tubular cells pose a challenge for liposome penetration due to their anatomical and physiological featu…
View article: A Pre-Clinical Study on the Use of the Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor PEP 2-8 to Mitigate Ischemic Injury in a Rat Marginal Donor Model
A Pre-Clinical Study on the Use of the Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor PEP 2-8 to Mitigate Ischemic Injury in a Rat Marginal Donor Model Open
Proprotein Convertase Subtilisin/Kexin type 9 PCSK9 inhibitors (PCSK9i) are a novel class of cholesterol-lowering agents that also offer protection against tissue ischemia by reducing apoptosis, pyroptosis, and myocardial infarct size. Thi…
View article: Case Report: Extracorporeal photopheresis for BK virus nephropathy as a novel treatment for high-risk rejection kidney transplant recipient
Case Report: Extracorporeal photopheresis for BK virus nephropathy as a novel treatment for high-risk rejection kidney transplant recipient Open
Background BK virus-associated nephropathy (BKVAN) is a major complication in kidney transplantation caused by the reactivation of latent BK virus (BKV) under immunosuppression. BKVAN has been strongly associated with increased graft loss.…
View article: FHR2 binds to HUVE necrotic cell and renal glomerular basal membrane, inhibiting TCC deposition and exhibiting cofactor activity
FHR2 binds to HUVE necrotic cell and renal glomerular basal membrane, inhibiting TCC deposition and exhibiting cofactor activity Open
View article: Can Proteomics Play a Significant Role in the Identification of Biomarkers for Alpha1-Antitrypsin Deficiency?
Can Proteomics Play a Significant Role in the Identification of Biomarkers for Alpha1-Antitrypsin Deficiency? Open
Alpha-1 antitrypsin deficiency (AATD) is a common genetic disorder that can manifest in a broad spectrum of clinical symptoms, ranging from asymptomatic cases to severe, progressive systemic diseases, primarily affecting the lungs and live…
View article: Can Proteomics Play a Significant Role in the Identification of Biomarkers for Alpha1-Antitrypsin Deficiency?
Can Proteomics Play a Significant Role in the Identification of Biomarkers for Alpha1-Antitrypsin Deficiency? Open
Alpha-1 antitrypsin deficiency (AATD) is a common genetic disorder that can manifest in a broad spectrum of clinical symptoms, ranging from asymptomatic cases to severe, progressive systemic diseases, primarily affecting the lungs and live…
View article: Pre-transplant IE1-specific T-cell response and CD8+ T-cell count as predictive markers of treated HCMV reactivation in kidney transplant recipients
Pre-transplant IE1-specific T-cell response and CD8+ T-cell count as predictive markers of treated HCMV reactivation in kidney transplant recipients Open
Background Human cytomegalovirus (HCMV) infection represents a significant complication for kidney transplant recipients (KTRs). The goal of this study was to evaluate potential immunological markers at pre-transplant in HCMV-seropositive …
View article: Engineered ATP-Loaded Extracellular Vesicles Derived from Mesenchymal Stromal Cells: A Novel Strategy to Counteract Cell ATP Depletion in an In Vitro Model
Engineered ATP-Loaded Extracellular Vesicles Derived from Mesenchymal Stromal Cells: A Novel Strategy to Counteract Cell ATP Depletion in an In Vitro Model Open
The use of adenosine triphosphate (ATP) has shown promising effects in alleviating ischemic damage across various tissues. However, the penetration of ATP into kidney tubular cells presents a challenge due to their unique anatomical and ph…
View article: Atypical Hemolytic Uremic Syndrome Associated with BNT162b2 mRNA COVID-19 Vaccine in a Kidney Transplant Recipient: A Case Report and Literature Review
Atypical Hemolytic Uremic Syndrome Associated with BNT162b2 mRNA COVID-19 Vaccine in a Kidney Transplant Recipient: A Case Report and Literature Review Open
Case Report: We report a case of a 37-year-old female with kidney transplant, who was admitted at our hospital due to worsening renal function, nephrotic proteinuria, and anemia developed 21 days after the second dose of BNT162b2 COVID-19 …
View article: Ethical Issues in Living Donor Kidney Transplantation: An Update from a Psychosocial Perspective
Ethical Issues in Living Donor Kidney Transplantation: An Update from a Psychosocial Perspective Open
Living donor kidney transplantation (LDKT) currently represents the treatment of choice for patients with end-stage renal failure. LDKT is a serious event with profound psychological, interpersonal, familial, and social implications. Over …
View article: Circulating Endothelin 1 but Not Transforming Growth Factor-β Levels Are Reduced after Pulmonary Endarterectomy in Subjects Affected by Chronic Thromboembolic Pulmonary Hypertension: A Prospective Cohort Study
Circulating Endothelin 1 but Not Transforming Growth Factor-β Levels Are Reduced after Pulmonary Endarterectomy in Subjects Affected by Chronic Thromboembolic Pulmonary Hypertension: A Prospective Cohort Study Open
Background and objectives: Endothelin-1 (ET-1) and transforming growth factor-β (TGF-β) play a pivotal role in the pathophysiology and vascular remodeling of chronic thromboembolic pulmonary hypertension (CTEPH) which is an under-diagnosed…
View article: The Impact of Serum/Plasma Proteomics on SARS-CoV-2 Diagnosis and Prognosis
The Impact of Serum/Plasma Proteomics on SARS-CoV-2 Diagnosis and Prognosis Open
While COVID-19’s urgency has diminished since its emergence in late 2019, it remains a significant public health challenge. Recent research reveals that the molecular intricacies of this virus are far more complex than initially understood…
View article: Immune Control of Human Cytomegalovirus (HCMV) Infection in HCMV-Seropositive Solid Organ Transplant Recipients: The Predictive Role of Different Immunological Assays
Immune Control of Human Cytomegalovirus (HCMV) Infection in HCMV-Seropositive Solid Organ Transplant Recipients: The Predictive Role of Different Immunological Assays Open
Human cytomegalovirus (HCMV) infection remains a major complication for solid organ transplant recipients (SOTRs). The aim of this study was to evaluate the role of HCMV-specific T cell immunity measured at the time of the HCMV-DNA peak in…
View article: Characterization of Mesenchymal Stromal Cells after Serum Starvation for Extracellular Vesicle Production
Characterization of Mesenchymal Stromal Cells after Serum Starvation for Extracellular Vesicle Production Open
It has been demonstrated that mesenchymal stromal cells (MSCs) act by releasing bioactive molecules, among these are extracellular vesicles (EVs). The MSC-EVs are considered a convenient alternative to cell therapy, showing several functio…
View article: #1446 PCSK9 inhibitor addition during hypothermic perfusion protects kidney from ischemic damage in a rat model of donation after circulatory death
#1446 PCSK9 inhibitor addition during hypothermic perfusion protects kidney from ischemic damage in a rat model of donation after circulatory death Open
Background and Aims PCSK9 inhibitors (PCSK9i) are a new class of cholesterol-lowering drugs that is gaining market share in treating hypercholesterolemia because of their effectiveness in lowering LDL cholesterol and cardiovascular risk, e…
View article: #1331 PCSK9 inhibitor addition during hypothermic perfusion protects kidney from ischemic damage in a rat model of donation after circulatory death
#1331 PCSK9 inhibitor addition during hypothermic perfusion protects kidney from ischemic damage in a rat model of donation after circulatory death Open
Background and Aims PCSK9 inhibitors (PCSK9i) are a new class of cholesterol-lowering drugs that is gaining market share in treating hypercholesterolemia because of their effectiveness in lowering LDL cholesterol and cardiovascular risk, e…
View article: #3232 ANTICOAGULANT RELATED NEPHROPATHY – AN UNDERDIAGNOSED COMPLICATION
#3232 ANTICOAGULANT RELATED NEPHROPATHY – AN UNDERDIAGNOSED COMPLICATION Open
Background and Aims Anticoagulant-related nephropathy (ARN) is an underdiagnosed complication of anticoagulant therapy (AT). Method We report 3 cases of ARN. Patient 1: 31 year-old male (M), kidney transplanted for reflux nephropathy, with…
View article: Yet another <i>in vitro</i> evidence that natural compounds introduced by diet have anti-amyloidogenic activities and can counteract neurodegenerative disease depending on aging
Yet another <i>in vitro</i> evidence that natural compounds introduced by diet have anti-amyloidogenic activities and can counteract neurodegenerative disease depending on aging Open
A major issue in Alzheimer's disease (AD) research is to find some new therapeutic drug which decrease Amyloid-beta (Aβ) aggregation. From a therapeutic point of view the major question is whether pharmacological inhibition of inflammation…
View article: ELISPOT assays with pp65 peptides or whole HCMV antigen are reliable predictors of immune control of HCMV infection in seropositive kidney transplant recipients
ELISPOT assays with pp65 peptides or whole HCMV antigen are reliable predictors of immune control of HCMV infection in seropositive kidney transplant recipients Open
Human cytomegalovirus (HCMV) infection represents a major complication for solid organ transplant recipients. The aim of this study was to verify if the measurement of HCMV‐specific T‐cells could help to identify patients protected against…
View article: Uremic plasma proteins accumulate in peripheral blood mononuclear leukocytes inducing apoptosis: insights in the immuno-proteostasis response of chronic kidney disease.
Uremic plasma proteins accumulate in peripheral blood mononuclear leukocytes inducing apoptosis: insights in the immuno-proteostasis response of chronic kidney disease. Open
Peripheral blood mononuclear leukocytes (PBL) of uremic patients (u-PBL) prematurely die by apoptosis, thus sustaining leukopenia and immune dysfunction. Uremic retention solutes have been alleged to playing a causal role in this immune ce…
View article: Supplementary Material for: Induction of vesicular trafficking and JNK-mediated apoptotic signaling in mononuclear leukocytes marks the immuno-proteostasis response to uremic proteins.
Supplementary Material for: Induction of vesicular trafficking and JNK-mediated apoptotic signaling in mononuclear leukocytes marks the immuno-proteostasis response to uremic proteins. Open
Introduction: Uremic retention solutes have been alleged to induce cell death in different cell types, including peripheral blood mononuclear leukocytes (PBL), which may contribute to uremic leukopenia and immune dysfunction. Methods: The …
View article: CD73-Adenosinergic Axis Mediates the Protective Effect of Extracellular Vesicles Derived from Mesenchymal Stromal Cells on Ischemic Renal Damage in a Rat Model of Donation after Circulatory Death
CD73-Adenosinergic Axis Mediates the Protective Effect of Extracellular Vesicles Derived from Mesenchymal Stromal Cells on Ischemic Renal Damage in a Rat Model of Donation after Circulatory Death Open
We propose a new organ-conditioning strategy based on mesenchymal stromal cell (MSCs)/extracellular vesicle (EVs) delivery during hypothermic perfusion. MSCs/EVs marker CD73 is present on renal proximal tubular cells, and it protects again…
View article: Nuclear Amyloid Fibrils Detected in Human SH-SY5Y Cells in Presence of Aβ1-42 and LPS
Nuclear Amyloid Fibrils Detected in Human SH-SY5Y Cells in Presence of Aβ1-42 and LPS Open
Amyloid-β peptide (Aβ) represents the main component of amyloid plaques in Alzheimer's disease (AD); Aβ belongs to the group of antimicrobial peptides (AMPs) small peptides that kill pathogens through their antimicrobial activity and also …
View article: Liposome Formulation and In Vitro Testing in Non-Physiological Conditions Addressed to Ex Vivo Kidney Perfusion
Liposome Formulation and In Vitro Testing in Non-Physiological Conditions Addressed to Ex Vivo Kidney Perfusion Open
This work focuses on formulating liposomes to be used in isolated kidney dynamic machine perfusion in hypothermic conditions as drug delivery systems to improve preservation of transplantable organs. The need mainly arises from use of kidn…