Teresa Santiago
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View article: Evaluation of <scp>0.55T MRI</scp> for Simultaneous <scp>R2*</scp> and Fat Fraction Quantification in the Presence of Hepatic Iron Overload and Steatosis Using Simulations and Phantoms
Evaluation of <span>0.55T MRI</span> for Simultaneous <span>R2*</span> and Fat Fraction Quantification in the Presence of Hepatic Iron Overload and Steatosis Using Simulations and Phantoms Open
Purpose To create virtual liver models simulating the concurrent presence of hepatic iron overload and steatosis based on human liver histology and to assess the accuracy and precision of R2* and fat fraction (FF) estimation at 0.55T compa…
View article: IMPLEMENTATION OF HIGH-RESOLUTION HLA TYPING IN A PUBLIC HEMATOLOGY CENTER REVEALS NOVEL ALLELES AND IMPROVES DONOR REGISTRY REPRESENTATION IN THE BRAZILIAN AMAZON
IMPLEMENTATION OF HIGH-RESOLUTION HLA TYPING IN A PUBLIC HEMATOLOGY CENTER REVEALS NOVEL ALLELES AND IMPROVES DONOR REGISTRY REPRESENTATION IN THE BRAZILIAN AMAZON Open
View article: Case report: diagnostic challenges and long-term survival of a child with bronchial mucoepidermoid carcinoma
Case report: diagnostic challenges and long-term survival of a child with bronchial mucoepidermoid carcinoma Open
Clinical presentation of bronchial MEC is similar to that of other pulmonary neoplasms. In our challenging case, the identification of CRTC3::MAML2 fusion was essential for diagnosis. The successful outcome in this case was made pos…
View article: Wilms Tumor in Children With <i>AMER1/WTX</i> Germline Pathogenic Variants: A Multicenter Case Series
Wilms Tumor in Children With <i>AMER1/WTX</i> Germline Pathogenic Variants: A Multicenter Case Series Open
Background 10–15% of children with Wilms tumor (WT) have predisposing genetic syndromes. Somatic mutations are frequently identified; however, germline pathogenic variants in AMER1 are much less prevalent and are associated with osteopathi…
View article: Novel <i>ACTB::FER</i> Promoter Swap Fusion Characterizes Rare Superficial Myoid/Myofibroblastic Tumors
Novel <i>ACTB::FER</i> Promoter Swap Fusion Characterizes Rare Superficial Myoid/Myofibroblastic Tumors Open
Pediatric fibroblastic, myofibroblastic, and myoid tumors encompass several entities, many with characteristic gene fusions that are now emerging as molecularly defined tumor groups. Here, we present two cases of spindle cell neoplasms wit…
View article: Prospective Evaluation of the Pathologic Diagnosis and Treatment Outcomes of Pediatric Burkitt Lymphoma in the Central American Pediatric Hematology-Oncology Association Consortium
Prospective Evaluation of the Pathologic Diagnosis and Treatment Outcomes of Pediatric Burkitt Lymphoma in the Central American Pediatric Hematology-Oncology Association Consortium Open
PURPOSE Clinical and histopathologic diagnosis of pediatric mature B-cell lymphomas (eg, Burkitt lymphoma [BL]) must be accurate to select appropriate risk-based treatment. The Central American Pediatric Hematology-Oncology Association (AH…
View article: 12485 Evaluating B7-H3-CAR T Cell Therapy In Preclinical Models Of Pediatric Adrenocortical Tumors
12485 Evaluating B7-H3-CAR T Cell Therapy In Preclinical Models Of Pediatric Adrenocortical Tumors Open
Disclosure: E.M. Pinto: None. R. Epperly: None. T. Santiago: None. H. Sheppard: None. M. Clay: None. C. Morton: None. P. Nguyen: None. Y. Zhou: None. M.A. Woolard: None. C. O'Reilly: None. J. Justice: None. W. Akers: None. M. Johnson: None…
View article: <i>MYH9::LTK</i> Fusion in a Pediatric Acral Soft Tissue Spindle Cell Neoplasm
<i>MYH9::LTK</i> Fusion in a Pediatric Acral Soft Tissue Spindle Cell Neoplasm Open
View article: Transcriptome profiling of pediatric extracranial solid tumors and lymphomas enables rapid low-cost diagnostic classification
Transcriptome profiling of pediatric extracranial solid tumors and lymphomas enables rapid low-cost diagnostic classification Open
Approximately 80% of pediatric tumors occur in low- and middle-income countries (LMIC), where diagnostic tools essential for treatment decisions are often unavailable or incomplete. Development of cost-effective molecular diagnostics will …
View article: Wilms Tumor with Vena Caval Intravascular Extension: A Surgical Perspective
Wilms Tumor with Vena Caval Intravascular Extension: A Surgical Perspective Open
Wilms tumor (WT) is the most common kidney tumor in pediatric patients. Intravascular extension of WT above the level of the renal veins is a rare manifestation that complicates surgical management. Patients with intravascular extension ar…
View article: <i>Choanephora infundibulifera</i> Rhinosinusitis in Man with Acute Lymphoblastic Leukemia, Tennessee, USA
<i>Choanephora infundibulifera</i> Rhinosinusitis in Man with Acute Lymphoblastic Leukemia, Tennessee, USA Open
Choanephora infundibulifera is a member of the Mucorales order of fungi. The species is associated with plants as a saprophyte or parasite and may be responsible for spoilage or disease but is an uncommon cause of human infection. We descr…
View article: Response of bilateral Wilms tumor to chemotherapy suggests histologic subtype and guides treatment
Response of bilateral Wilms tumor to chemotherapy suggests histologic subtype and guides treatment Open
Background Patients with bilateral Wilms tumor initially receive neoadjuvant chemotherapy to shrink the tumors and increase the likelihood of successful nephron-sparing surgery. Biopsy of poorly responding tumors is often done to better un…
View article: Regional lymph node evaluation in pediatric conventional melanoma subtype: a single-center 10-year review
Regional lymph node evaluation in pediatric conventional melanoma subtype: a single-center 10-year review Open
Purpose To assess the prognostic and therapeutic significance of sentinel lymph node biopsy (SLNB) and completion lymph node dissection (CLND) in pediatric conventional melanoma (CM), while evaluating potential predictive factors for outco…
View article: Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children’s Oncology Group AREN18B5-Q
Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children’s Oncology Group AREN18B5-Q Open
View article: Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma
Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma Open
View article: Feasibility of indocyanine green‐guided localization of pulmonary nodules in children with solid tumors
Feasibility of indocyanine green‐guided localization of pulmonary nodules in children with solid tumors Open
Background Clearing all pulmonary metastases is essential for curing pediatric solid tumors. However, intraoperative localization of such pulmonary nodules can be challenging. Therefore, an intraoperative tool that localizes pulmonary meta…
View article: Supplementary Tables 1-5 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma
Supplementary Tables 1-5 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma Open
Supplementary Table 1. Validated Tier 1-3 Mutation CallsSupplementary Table 2. Genes Upregulated in CIC-NUTM2ASupplementary Table 3. CIC-NUTM2A Gene Set Enrichment Analysis in Pediatric Hematologic MalignanciesSupplementary Table 4. ssGSEA…
View article: Supplementary Figures 1-7 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma
Supplementary Figures 1-7 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma Open
Supplementary Methods and FiguresSupplementary Figure 1. A newborn with isolated myeloid sarcoma.Supplementary Figure 2. Myeloid Sarcoma Histology.Supplementary Figure 3. Bone Marrow.Supplementary Figure 4. Genes Upregulated in CIC-NUTM2A.…
View article: Data from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma
Data from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma Open
Myeloid sarcoma is a rare condition consisting of extramedullary myeloid blasts found in association with acute myeloid leukemia or, in the absence of bone marrow involvement. We identified an infant with isolated myeloid sarcoma whose bon…
View article: Supplementary Figures 1-7 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma
Supplementary Figures 1-7 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma Open
Supplementary Methods and FiguresSupplementary Figure 1. A newborn with isolated myeloid sarcoma.Supplementary Figure 2. Myeloid Sarcoma Histology.Supplementary Figure 3. Bone Marrow.Supplementary Figure 4. Genes Upregulated in CIC-NUTM2A.…
View article: Supplementary Tables 1-5 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma
Supplementary Tables 1-5 from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma Open
Supplementary Table 1. Validated Tier 1-3 Mutation CallsSupplementary Table 2. Genes Upregulated in CIC-NUTM2ASupplementary Table 3. CIC-NUTM2A Gene Set Enrichment Analysis in Pediatric Hematologic MalignanciesSupplementary Table 4. ssGSEA…
View article: Data from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma
Data from Malignant Progression of an Ancestral Bone Marrow Clone Harboring a <i>CIC-NUTM2A</i> Fusion in Isolated Myeloid Sarcoma Open
Myeloid sarcoma is a rare condition consisting of extramedullary myeloid blasts found in association with acute myeloid leukemia or, in the absence of bone marrow involvement. We identified an infant with isolated myeloid sarcoma whose bon…
View article: Progressive metastatic infantile fibrosarcoma with multiple acquired mutations
Progressive metastatic infantile fibrosarcoma with multiple acquired mutations Open
Infantile fibrosarcoma is the most common soft-tissue sarcoma in children under the age of 1 yr and is defined molecularly by NTRK fusion proteins. This tumor is known to be locally invasive; however, although rare, metastases can occur. T…
View article: The Genetic and Epigenetic Features of Bilateral Wilms Tumor Predisposition: A Report from the Children's Oncology Group AREN18B5-Q Study
The Genetic and Epigenetic Features of Bilateral Wilms Tumor Predisposition: A Report from the Children's Oncology Group AREN18B5-Q Study Open
View article: Preferentially Expressed Antigen in Melanoma (PRAME) Expression Utility in Distinguishing Desmoplastic and Spindle Cell Melanomas from Malignant Peripheral Nerve Sheath Tumors
Preferentially Expressed Antigen in Melanoma (PRAME) Expression Utility in Distinguishing Desmoplastic and Spindle Cell Melanomas from Malignant Peripheral Nerve Sheath Tumors Open
Spindle cell and desmoplastic melanoma (DM) are uncommon melanoma subtypes; both are composed of elongated “spindled cells” but differ from one another based on the extent of desmoplastic stroma separating individual tumor cells. These can…
View article: Giant focal nodular hyperplasia with a background of hepatic steatosis in a 14-year-old boy
Giant focal nodular hyperplasia with a background of hepatic steatosis in a 14-year-old boy Open
Giant focal nodular hyperplasia (GFNH) is rarely seen in children, presenting complex diagnostic and management considerations. Pathognomonic radiographic findings can be absent in this population, and the nuances of pathologic examination…
View article: Risk factors associated with metastatic site failure in patients with high-risk neuroblastoma
Risk factors associated with metastatic site failure in patients with high-risk neuroblastoma Open
View article: Malignant Peripheral Nerve Sheath Tumors—A Comprehensive Review of Pathophysiology, Diagnosis, and Multidisciplinary Management
Malignant Peripheral Nerve Sheath Tumors—A Comprehensive Review of Pathophysiology, Diagnosis, and Multidisciplinary Management Open
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas (STS) with nerve sheath differentiation and a tendency to metastasize. Although occurring at an incidence of 0.001% in the general population, they are r…
View article: Bilateral Diffuse Nodular Pulmonary Ossification Mimicking Metastatic Disease in a Patient with Fibrolamellar Hepatocellular Carcinoma
Bilateral Diffuse Nodular Pulmonary Ossification Mimicking Metastatic Disease in a Patient with Fibrolamellar Hepatocellular Carcinoma Open
Pulmonary ossification (PO) is a rare finding, characterized by mature bone formation in the lung parenchyma. We report a 20-year-old female patient diagnosed with fibrolamellar hepatocellular carcinoma (FL-HCC) and bilateral diffuse nodul…
View article: Creation of a successful multidisciplinary course in pediatric neuro‐oncology with a systematic approach to curriculum development
Creation of a successful multidisciplinary course in pediatric neuro‐oncology with a systematic approach to curriculum development Open
Background The St Jude Global Academy Neuro‐Oncology Training Seminar (NOTS) is a hybrid course in pediatric neuro‐oncology specifically designed for physicians from low‐income and middle‐income countries. Methods The curriculum for the co…