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View article: 1088 Cancer immune checkpoint therapy efficacy and machine learning outcome predictions as stratified by smoking status and cancer type – a multi-national database study
1088 Cancer immune checkpoint therapy efficacy and machine learning outcome predictions as stratified by smoking status and cancer type – a multi-national database study Open
View article: Health system and household costs of preventive treatment delivery for children exposed to multidrug-resistant tuberculosis in South Africa
Health system and household costs of preventive treatment delivery for children exposed to multidrug-resistant tuberculosis in South Africa Open
Background Tuberculosis (TB) preventive treatment (TPT) is a core component of TB control. Levofloxacin was recently recommended by the World Health Organization as TPT in children exposed to multidrug-resistant tuberculosis (MDR-TB). Howe…
View article: Molecular pathophysiology of SCN5A-related cardiac arrhythmias in children: phenotype spectrum and potential therapeutic targets
Molecular pathophysiology of SCN5A-related cardiac arrhythmias in children: phenotype spectrum and potential therapeutic targets Open
Pathogenic variants in SCN5A, encoding the cardiac sodium channel Nav1.5, are responsible for a diverse spectrum of potentially life-threatening arrhythmias in children. This review examines the molecular pathophysiology of SCN5A-related c…
View article: Embracing paradoxes to fuel entrepreneurial intentions: The moderating role of temporal focus
Embracing paradoxes to fuel entrepreneurial intentions: The moderating role of temporal focus Open
Drawing upon the paradox theory, this study examines how an individual’s paradox mindset drives their entrepreneurial intentions via entrepreneurial self-efficacy under the moderation of past, current, and future focus. Findings from Study…
View article: Atypical presentation of Adult T-Cell Leukemia/Lymphoma in a United States Veteran exposed to Human T-lymphotropic virus type-1.
Atypical presentation of Adult T-Cell Leukemia/Lymphoma in a United States Veteran exposed to Human T-lymphotropic virus type-1. Open
View article: Environmental impacts on skin genomics: molecular mechanisms of photoaging and protective strategies
Environmental impacts on skin genomics: molecular mechanisms of photoaging and protective strategies Open
Skin, as the body’s primary environmental interface, is continuously exposed to various environmental stressors that significantly impact its genomic integrity and accelerate aging processes. This mini review summarizes current knowledge o…
View article: 0373 VEXAS syndrome: A case of misdiagnosed dermatologic and rheumatologic manifestations in a 77-year-old male
0373 VEXAS syndrome: A case of misdiagnosed dermatologic and rheumatologic manifestations in a 77-year-old male Open
View article: Pathways to Green Purchase Intention in FMCG Industry: A Combined Approach of PLS-SEM and fsQCA
Pathways to Green Purchase Intention in FMCG Industry: A Combined Approach of PLS-SEM and fsQCA Open
This study examines the impact of green marketing strategies on consumer green purchase intention in the fast-moving consumer goods (FMCG) industry in an emerging market, investigating the mediating roles of green trust and green brand ima…
View article: Risk of Tuberculosis Infection in Young Children Exposed to Multidrug-resistant Tuberculosis in the TB-CHAMP Multi-site Randomized Controlled Trial
Risk of Tuberculosis Infection in Young Children Exposed to Multidrug-resistant Tuberculosis in the TB-CHAMP Multi-site Randomized Controlled Trial Open
Background Young children have a high risk of developing tuberculosis (TB) disease following infection with Mycobacterium tuberculosis in the absence of preventive treatment. Infection prevalence and risk factors for infection impact deliv…
View article: U-shaped Relationship between FinancialDevelopment and Greenhouse Gasesin Vietnam: ARDL Bound Test Approach
U-shaped Relationship between FinancialDevelopment and Greenhouse Gasesin Vietnam: ARDL Bound Test Approach Open
View article: Acceptability of a 250 mg levofloxacin formulation in children receiving TB preventive treatment
Acceptability of a 250 mg levofloxacin formulation in children receiving TB preventive treatment Open
BACKGROUNDRecent evidence indicates that levofloxacin (LFX) is effective in preventing TB in individuals exposed to multidrug-resistant TB (MDR-TB). Despite the need for pediatric formulations, the 250 mg adult LFX formulation is affordabl…
View article: A systematic review exploring the role of tuberculosis stigma on test and treatment uptake for tuberculosis infection
A systematic review exploring the role of tuberculosis stigma on test and treatment uptake for tuberculosis infection Open
View article: Hidradenitis Suppurativa Is Associated with an Increased Risk of Adverse Cardiac Events and All-Cause Mortality
Hidradenitis Suppurativa Is Associated with an Increased Risk of Adverse Cardiac Events and All-Cause Mortality Open
Background: Hidradenitis suppurativa (HS) has been previously associated with greater rates of major adverse cardiac events (MACEs) compared to the general population. This study aims to better elucidate the association between HS, MACEs, …
View article: Real-world safety profile of therapy with ibrutinib or acalabrutinib in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma
Real-world safety profile of therapy with ibrutinib or acalabrutinib in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma Open
View article: A Meta-Analysis of Levofloxacin for Contacts of Multidrug-Resistant Tuberculosis
A Meta-Analysis of Levofloxacin for Contacts of Multidrug-Resistant Tuberculosis Open
In this meta-analysis of two randomized trials, levofloxacin was associated with a 60% relative reduction in TB incidence among adult and child household MDR-TB contacts, but with an increased risk of musculoskeletal adverse events. (Funde…
View article: 600 Differential gene enrichment in response to durvalumab and metformin in head and neck cancer patients: the role of the neutrophil to lymphocyte ratio (NLR) and epithelial mesenchymal transition (EMT)
600 Differential gene enrichment in response to durvalumab and metformin in head and neck cancer patients: the role of the neutrophil to lymphocyte ratio (NLR) and epithelial mesenchymal transition (EMT) Open
View article: Health and illness beliefs in adults with tuberculosis infection during the COVID-19 pandemic in the UK
Health and illness beliefs in adults with tuberculosis infection during the COVID-19 pandemic in the UK Open
NIHR RID-TB Program (RP-PG-0217-20009).
View article: EP144/#481 Sentinel lymph node mapping and dissection using methylene blue: the danang oncology hospital experience of the first 31 cases
EP144/#481 Sentinel lymph node mapping and dissection using methylene blue: the danang oncology hospital experience of the first 31 cases Open
Objectives Endometrial cancer is the most commonly diagnosed gynecological malignancy in Vietnam, after breast cancer. The primary treatment is based on surgical and pathologic staging including hysterectomy, bilateral salpingo-oophorectom…
View article: Evaluating the effect of short-course rifapentine-based regimens with or without enhanced behaviour-targeted treatment support on adherence and completion of treatment for latent tuberculosis infection among adults in the UK (RID-TB: Treat): protocol for an open-label, multicentre, randomised controlled trial
Evaluating the effect of short-course rifapentine-based regimens with or without enhanced behaviour-targeted treatment support on adherence and completion of treatment for latent tuberculosis infection among adults in the UK (RID-TB: Treat): protocol for an open-label, multicentre, randomised controlled trial Open
Introduction The successful scale-up of a latent tuberculosis (TB) infection testing and treatment programme is essential to achieve TB elimination. However, poor adherence compromises its therapeutic effectiveness. Novel rifapentine-based…
View article: Randomised controlled trial to evaluate the effectiveness of using the RD-1-based C-Tb skin test as a replacement for blood-based interferon-γ release assay for detection of, and initiation of preventive treatment for, tuberculosis infection: RID-TB:Dx study protocol
Randomised controlled trial to evaluate the effectiveness of using the RD-1-based C-Tb skin test as a replacement for blood-based interferon-γ release assay for detection of, and initiation of preventive treatment for, tuberculosis infection: RID-TB:Dx study protocol Open
Introduction The predictive utility for incident tuberculosis (TB) of the purified protein derivative tuberculin skin test and region of difference 1 (RD1)-based interferon-gamma release assays (IGRA) is comparable; and either is recommend…
View article: Integrating analysis of the expression of IDO1 and TDO2 in bladder cancer
Integrating analysis of the expression of IDO1 and TDO2 in bladder cancer Open
View article: Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme
Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme Open
View article: Table of Contents
Table of Contents Open
View article: Transdermal oestradiol as a method of androgen suppression for prostate cancer within the STAMPEDE trial platform
Transdermal oestradiol as a method of androgen suppression for prostate cancer within the STAMPEDE trial platform Open
Androgen deprivation therapy (ADT) remains a cornerstone of the management of prostate cancer. The addition of ADT to radiotherapy improves disease-free and overall survival in the locally advanced setting and ADT forms the backbone onto w…
View article: Quality‐of‐life outcomes from the Prostate Adenocarcinoma: TransCutaneous Hormones ( <scp>PATCH</scp> ) trial evaluating luteinising hormone‐releasing hormone agonists versus transdermal oestradiol for androgen suppression in advanced prostate cancer
Quality‐of‐life outcomes from the Prostate Adenocarcinoma: TransCutaneous Hormones ( <span>PATCH</span> ) trial evaluating luteinising hormone‐releasing hormone agonists versus transdermal oestradiol for androgen suppression in advanced prostate cancer Open
Objectives To compare quality‐of‐life (QoL) outcomes at 6 months between men with advanced prostate cancer receiving either transdermal oestradiol ( tE 2) or luteinising hormone‐releasing hormone agonists ( LHRH a) for androgen‐deprivation…
View article: A Randomised Comparison Evaluating Changes in Bone Mineral Density in Advanced Prostate Cancer: Luteinising Hormone-releasing Hormone Agonists Versus Transdermal Oestradiol
A Randomised Comparison Evaluating Changes in Bone Mineral Density in Advanced Prostate Cancer: Luteinising Hormone-releasing Hormone Agonists Versus Transdermal Oestradiol Open
ISRCTN70406718, PATCH trial (ClinicalTrials.gov NCT00303784).
View article: Outcomes after viral load rebound on first-line antiretroviral treatment in children with HIV in the UK and Ireland: an observational cohort study
Outcomes after viral load rebound on first-line antiretroviral treatment in children with HIV in the UK and Ireland: an observational cohort study Open