Explanipedia

Author Correction: Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome Open

Petri Vänni, Mysore V. Tejesvi, Sofia Ainonen, Marjo Renko, Katja Korpela , et al. · 2023

Maternal microbiota communicates with the fetus through microbiota-derived extracellular vesicles Open

Anna Kaisanlahti, Jenni Turunen, Nadiya Byts, Anatoly Samoylenko, Geneviève Bart , et al. · 2023

<i>Streptococcus salivarius</i> Probiotics to Prevent Acute Otitis Media in Children Open

Suvi Sarlin, Ulla Koskela, Minna Honkila, Paula A. Tähtinen, Tytti Pokka , et al. · 2023

Importance New approaches for the prevention of acute otitis media (AOM), the most common reason for antibiotic use in children, are needed. Objective To assess the efficacy of the Streptococcus salivarius K12 oral probiotics in the primar…

Machine-learning analysis of cross-study samples according to the gut microbiome in 12 infant cohorts Open

Petri Vänni, Mysore V. Tejesvi, Niko Paalanne, Kjersti M. Aagaard, Gail Ackermann , et al. · 2023

Combining and comparing microbiome data from distinct infant cohorts has been challenging because such data are inherently multidimensional and complex. Here, we used an ensemble of machine-learning (ML) models and studied 16S rRNA amplico…

Antenatal corticosteroid treatment and infectious diseases in children: a nationwide observational study Open

Katri Räikkönen, Mika Gissler, Eero Kajantie, Terhi Tapiainen · 2023

Clinical Outcomes of Acutely Ill Children According to Cycle Threshold Values of Respiratory Viruses Detected by Multiplex PCR Testing Open

Suvi Mattila, Minna Honkila, Niko Paalanne, Vesa Mäki-Koivisto, Kimmo Halt , et al. · 2023

In this cohort study of 800 children attending a pediatric emergency department at Oulu University Hospital, Finland with fever or respiratory symptoms, the cycle threshold values of point-of-care multiplex polymerase chain reaction testin…

Perinatal and Other Risk Factors for Common Infections in Infancy: A Prospective Cohort Study Open

Sanni Hyvönen, Terhi Tapiainen, Tytti Pokka, Terhi Solasaari, Katri Korpela , et al. · 2023

Objective: Limited data from prospective cohort studies in high-income countries are available on the perinatal risk factors for common infections in children. Our hypothesis was that perinatal factors may be risk factors for infectious ep…

Bacterial extracellular vesicles – brain invaders? A systematic review Open

Anna Kaisanlahti, Sonja Salmi, Sohvi Kumpula, Sajeen Bahadur Amatya, Jenni Turunen , et al. · 2023

Introduction Knowledge on the human gut microbiota in health and disease continues to rapidly expand. In recent years, changes in the gut microbiota composition have been reported as a part of the pathology in numerous neurodegenerative di…

Investigating prenatal and perinatal factors on meconium microbiota: a systematic review and cohort study Open

Jenni Turunen, Mysore V. Tejesvi, Niko Paalanne, Tytti Pokka, Sajeen Bahadur Amatya , et al. · 2023

Tonsillotomy for Periodic Fever Syndrome: A Randomized and Controlled Trial Open

Ulla Lantto, Terhi Tapiainen, Tytti Pokka, Petri Koivunen, Merja Helminen , et al. · 2023

Objective Tonsillectomy is an effective treatment for periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. Tonsillotomy has a milder operative risk profile and postoperative morbidity in children than t…

Delivery Mode and Perinatal Antibiotics Influence the Infant Gut Bacteriome and Mycobiome: A Network Analysis Open

Mysore V. Tejesvi, Jenni Turunen, Sonja Salmi, Justus Reunanen, Niko Paalanne , et al. · 2023

Both exposure to antibiotics at birth and delivery via Caesarean section influence the gut bacteriome’s development in infants. Using 16S rRNA and internal transcribed spacer sequencing on the Ion Torrent platform, we employed network anal…

Development of gut mycobiome in infants and young children: a prospective cohort study Open

Jenni Turunen, Niko Paalanne, Justus Reunanen, Terhi Tapiainen, Mysore V. Tejesvi · 2023

Background The composition of the gut fungal microbiome, mycobiome, is likely associated with human health. Yet, the development of gut mycobiome is poorly understood in infants and children. Here we investigate how perinatal events influe…

Cranberry‐lingonberry juice affects the gut and urinary microbiome in children ‐ a randomized controlled trial Open

Mikael Hakkola, Pekka Vehviläinen, Janita Muotka, Mysore V. Tejesvi, Tytti Pokka , et al. · 2023

The mechanism by which cranberry‐lingonberry juice (CLJ) prevents urinary tract infections (UTI) in children remains unknown. We hypothesized that it alters the composition of the gut or urinary microbiome. Altogether, 113 children with UT…

516. Delivery Mode and Intrapartum Antibiotics Affect the Gut Mycobiome in Newborn Infants and Young Children Open

Jenni Turunen, Niko Paalanne, Justus Reunanen, Terhi Tapiainen, Mysore V. Tejesvi · 2022

Background The gut mycobiome may have important effects on health. Yet, there is limited data on the mycobiome. Previously, we have shown that antibiotic exposure at birth markedly alters the gut bacteriome in children. As fungi and bacter…

Effect of Topical Antibiotics on Duration of Acute Infective Conjunctivitis in Children Open

Minna Honkila, Ulla Koskela, Tero Kontiokari, Marja‐Leena Mattila, Aila Kristo , et al. · 2022

Importance Although topical antibiotics are often prescribed for treating acute infective conjunctivitis in children, their efficacy is uncertain. Objective To assess the efficacy of topical antibiotic therapy for acute infective conjuncti…

Unusual late epidemic peak during influenza season 2021–2022: A nationwide register‐based analysis in Finland Open

Ilari Kuitunen, Marjo Renko, Terhi Tapiainen · 2022

Social restrictions set due to COVID-19 interrupted the circulation of influenza in March 2020 in Finland and globally.1-3 Finland had lockdown from March 2020 to May 2020 and since then, Finland has had regional restrictions and traveling…

Associations Between Maternal Antenatal Corticosteroid Treatment and Psychological Developmental and Neurosensory Disorders in Children Open

Katri Räikkönen, Mika Gissler, Terhi Tapiainen, Eero Kajantie · 2022

This study suggests that the possible long-term psychological developmental and neurosensory harms warrant careful consideration of risks and benefits when deciding on maternal antenatal corticosteroid treatment.

Parental Ability to Assess Pediatric Vital Signs Open

Hilla Pöyry, Henri Aarnivala, Heikki Huhtamäki, Tytti Pokka, Marjo Renko , et al. · 2022

Parents were not able to assess their child's RR or HR accurately. Digital remote assessment of children should not rely on parental measurements of vital signs.

Mycoplasma pneumoniae beyond the COVID-19 pandemic: where is it? Open

Patrick M. Meyer Sauteur, Victoria J. Chalker, Christoph Berger, Ran Nir‐Paz, Michael L. Beeton , et al. · 2022

Mycoplasma pneumoniae is a major bacterial cause of respiratory tract infection.1Waites KB Talkington DF Mycoplasma pneumoniae and its role as a human pathogen.Clin Microbiol Rev. 2004; 17: 697-728Crossref PubMed Scopus (926) Google Schola…

Bacterial extracellular vesicles in the microbiome of first-pass meconium in newborn infants Open

Jenni Turunen, Mysore V. Tejesvi, Marko Suokas, Nikke Virtanen, Niko Paalanne , et al. · 2022

The end of <span>COVID</span>‐19 restrictions for children in autumn 2021 was followed by an unusually early, high‐peak respiratory syncytial virus epidemic Open

Ilari Kuitunen, Marjo Renko, Terhi Tapiainen · 2022

Strict COVID-19 restrictions were established in Finland in March 2020. This reduced the circulation of respiratory viral pathogens among children,1 except the rhinovirus, which showed little change.2 During the 2020–2021 winter season, ge…

Meta-analysis of the Risk Factors for Urinary Tract Infection in Children Open

Marjo Renko, Jarmo Salo, Milka Ekstrand, Tytti Pokka, Oskari Pieviläinen , et al. · 2022

Context: The incidence of urinary tract infection (UTI) varies with age, but there is limited evidence on the role of other risk factors. Objective: The aim of this meta-analysis was to investigate the risk factors for UTIs in children. Da…

Effect of Point-of-Care Testing for Respiratory Pathogens on Antibiotic Use in Children Open

Suvi Mattila, Niko Paalanne, Minna Honkila, Tytti Pokka, Terhi Tapiainen · 2022

ClinicalTrials.gov Identifier: NCT03932942.

PB2271: GERMLINE LOSS OF RHOG IDENTIFIES ITS ROLE AS AN ESSENTIAL REGULATOR OF HUMAN LYMPHOCYTE CYTOTOXICITY Open

Artem Kalinichenko, Giovanna Perinetti Casoni, L. Dupré, Luca Trotta, Jakob Huemer , et al. · 2022

Background: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition of severe hyper-inflammation characterized by immune dysregulation and massive, aberrant activation of cytotoxic T cells and macrophages. While the molecu…

Antibiotic courses for acute otitis media alter human gut microbiome resistome and colonization resistance against antimicrobial resistant species in children Open

Weizhong Li, Katja Kielenniva, Claire Kuelbs, Mark Novotny, Tero Kontiokari , et al. · 2022

Antimicrobial resistance (AMR) is a major global public health problem. Human gut microbiome plays an important role in modulating AMR. On one hand, the microbiome itself can serve as a reservoir of AMR genes, i.e. resistome. On the other …

The incidence, hospitalisations and deaths in acutely ill children with dysnatraemias Open

Saara Lehtiranta, Minna Honkila, Silja Anttila, Heikki Huhtamäki, Tytti Pokka , et al. · 2022

Aim The aim was to evaluate the incidence, hospitalisations and deaths in acutely ill children with dysnatraemias. Methods This was a register‐based cohort study of 46 518 acutely ill children aged <16 years who visited a paediatric emerge…

Microbiota of the first‐pass meconium and subsequent atopic and allergic disorders in children Open

Katja Kielenniva, Sofia Ainonen, Petri Vänni, Niko Paalanne, Marjo Renko , et al. · 2022

Background Some cohort studies have suggested that gut microbiota composition is associated with allergic diseases in children. The microbiota of the first‐pass meconium, which forms before birth, represents the first gut microbiota that i…

Presence of distinctive microbiome in the first-pass meconium of newborn infants Open

Jenni Turunen, Mysore V. Tejesvi, Niko Paalanne, Jenni Hekkala, Outi Lindgren , et al. · 2021

Correction to: Severe hospital‑acquired hyponatremia in acutely ill children receiving moderately hypotonic fluids Open

Saara Lehtiranta, Minna Honkila, Merja Kallio, Kimmo Halt, Niko Paalanne , et al. · 2021

Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome Open

Petri Vänni, Mysore V. Tejesvi, Sofia Ainonen, Marjo Renko, Katja Korpela , et al. · 2021

Delivery mode and perinatal antibiotics influence gut microbiome composition in children. Most microbiome studies have used the sequencing of the bacterial 16S marker gene but have not reported the metabolic function of the gut microbiome,…

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