Terkild B. Buus
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View article: Data from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer
Data from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer Open
Evolution and outgrowth of drug-resistant cancer cells are common causes of treatment failure. Patients with leukemic cutaneous T-cell lymphoma have a poor prognosis because of the development of drug resistance and severe bacterial infect…
View article: Table S2 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer
Table S2 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer Open
Antibodies used (with vendor, catalogue number and RRID)
View article: Table S1 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer
Table S1 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer Open
Patient information
View article: Supplementary Figures S1-S17 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer
Supplementary Figures S1-S17 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer Open
S1 shows sample and analysis pipeline overview. S2 shows malignant-associated gene and surface marker expression in PT17. S3 shows single-cell subclone identification by scTCR-seq, transcriptome and copy-number aberration inference. S4 sho…
View article: Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer
Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer Open
Evolution and outgrowth of drug-resistant cancer cells are common causes of treatment failure. Patients with leukemic cutaneous T-cell lymphoma have a poor prognosis because of the development of drug resistance and severe bacterial infect…
View article: RUNX2 as a novel biomarker for early identification of patients progressing to advanced-stage mycosis fungoides
RUNX2 as a novel biomarker for early identification of patients progressing to advanced-stage mycosis fungoides Open
Introduction The majority of patients with mycosis fungoides (MF) have an indolent disease course, but a substantial fraction (20-30%) of patients progress to advanced stages – usually with a grave prognosis. Early differentiation between …
View article: Single-cell RNA and T-cell receptor sequencing unveil mycosis fungoides heterogeneity and a possible gene signature
Single-cell RNA and T-cell receptor sequencing unveil mycosis fungoides heterogeneity and a possible gene signature Open
Background Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma (CTCL). Comprehensive analysis of MF cells in situ and ex vivo is complicated by the fact that is challenging to distinguish malignant from reactive …
View article: Keratinocytes Present Staphylococcus aureus Enterotoxins and Promote Malignant and Nonmalignant T Cell Proliferation in Cutaneous T-Cell Lymphoma
Keratinocytes Present Staphylococcus aureus Enterotoxins and Promote Malignant and Nonmalignant T Cell Proliferation in Cutaneous T-Cell Lymphoma Open
View article: Type 1 immunity enables neonatal thymic ILC1 production
Type 1 immunity enables neonatal thymic ILC1 production Open
Acute thymic atrophy occurs following type 1 inflammatory conditions such as viral infection and sepsis, resulting in cell death and disruption of T cell development. However, the impact type 1 immunity has on thymic-resident innate lympho…
View article: <i>Staphylococcus aureus</i>induces drug resistance in cancer T cells in Sézary syndrome
<i>Staphylococcus aureus</i>induces drug resistance in cancer T cells in Sézary syndrome Open
Patients with Sézary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma (CTCL), are prone to Staphylococcus aureus infections and have a poor prognosis due to treatment resistance. Here, we report that S aureus and staphylococc…
View article: CITE-seq data from <b><i>Staphylococcus aureus</i></b><b> induce drug resistance in cancer T cells in Sézary Syndrome</b>
CITE-seq data from <b><i>Staphylococcus aureus</i></b><b> induce drug resistance in cancer T cells in Sézary Syndrome</b> Open
CITE-seq dataset of cells from a Sézary Syndrome patient cultured in the presence or absence of Romidepsin and/or S. aureus enterotoxins (SE) used in article:Chella Krishna Vadivel, Andreas Willerslev-Olsen, Martin Rich Javadi Namini, Ziao…
View article: mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection
mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection Open
View article: KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance
KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance Open
View article: In vitro differentiated human CD4+ T cells produce hepatocyte growth factor
In vitro differentiated human CD4+ T cells produce hepatocyte growth factor Open
Differentiation of naive CD4 + T cells into effector T cells is a dynamic process in which the cells are polarized into T helper (Th) subsets. The subsets largely consist of four fundamental categories: Th1, Th2, Th17, and regulatory T cel…
View article: Endolysin Inhibits Skin Colonization by Patient-Derived Staphylococcus Aureus and Malignant T-Cell Activation in Cutaneous T-Cell Lymphoma
Endolysin Inhibits Skin Colonization by Patient-Derived Staphylococcus Aureus and Malignant T-Cell Activation in Cutaneous T-Cell Lymphoma Open
Staphylococcus aureus is suspected to fuel disease activity in cutaneous T-cell lymphomas. In this study, we investigate the effect of a recombinant, antibacterial protein, endolysin (XZ.700), on S. aureus skin colonization and malignant T…
View article: Type 1 immunity enables neonatal thymic ILC1 production
Type 1 immunity enables neonatal thymic ILC1 production Open
Thymic atrophy occurs following type 1 inflammatory conditions like viral infection and sepsis, resulting in cell death and disruption of T-cell development. However, it remains undetermined whether the thymus actively contributes to the i…
View article: Phenotypic plasticity of malignant T cells in blood and skin of a Sézary syndrome patient revealed by single cell transcriptomics
Phenotypic plasticity of malignant T cells in blood and skin of a Sézary syndrome patient revealed by single cell transcriptomics Open
Background Sézary Syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphomas (CTCL). In SS patients, malignant T cells are circulating through the blood and cause erythroderma. Objective To compare the transcriptome of s…
View article: Malignant T cells induce skin barrier defects through cytokine-mediated JAK/STAT signaling in cutaneous T-cell lymphoma
Malignant T cells induce skin barrier defects through cytokine-mediated JAK/STAT signaling in cutaneous T-cell lymphoma Open
Cutaneous T-cell lymphoma (CTCL) is a devastating lymphoid malignancy characterized by the accumulation of malignant T cells in the dermis and epidermis. Skin lesions cause serious symptoms that hamper quality of life and are entry sites f…
View article: Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor
Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor Open
The glucagon-like peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an important therapeutic target in diabetes and obesity. Recent studies in experimental animals have shown that certain subsets of T cells express function…
View article: Oncogenic fusions JAK up CD8+ cytotoxic CTCL
Oncogenic fusions JAK up CD8+ cytotoxic CTCL Open
In this issue of Blood, Lee et al investigate the molecular etiology of cytotoxic cutaneous T-cell lymphoma (CTCL).Little is known about genetic events that lead to the malignant transformation of T cells in this collection of aggressive s…
View article: Multimodal single-cell analysis of cutaneous T-cell lymphoma reveals distinct subclonal tissue-dependent signatures
Multimodal single-cell analysis of cutaneous T-cell lymphoma reveals distinct subclonal tissue-dependent signatures Open
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of mature T-cell neoplasms characterized by the accumulation of clonal malignant CD4+ T cells in the skin. The most common variant of CTCL, mycosis fungoides (MF ), is confined to t…
View article: Impaired Vitamin D Signaling in T Cells From a Family With Hereditary Vitamin D Resistant Rickets
Impaired Vitamin D Signaling in T Cells From a Family With Hereditary Vitamin D Resistant Rickets Open
The active form of vitamin D, 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), mediates its immunomodulatory effects by binding to the vitamin D receptor (VDR). Here, we describe a new point mutation in the DNA-binding domain of the VDR and it…
View article: mRNA COVID-19 vaccine elicits potent adaptive immune response without the persistent inflammation seen in SARS-CoV-2 infection
mRNA COVID-19 vaccine elicits potent adaptive immune response without the persistent inflammation seen in SARS-CoV-2 infection Open
SARS-CoV-2 infection and vaccination elicit potent immune responses. Our study presents a comprehensive multimodal single-cell dataset of peripheral blood of patients with acute COVID-19 and of healthy volunteers before and after receiving…
View article: Publisher Correction: Inhibition of succinate dehydrogenase activity impairs human T cell activation and function
Publisher Correction: Inhibition of succinate dehydrogenase activity impairs human T cell activation and function Open
View article: Improving oligo-conjugated antibody signal in multimodal single-cell analysis
Improving oligo-conjugated antibody signal in multimodal single-cell analysis Open
Simultaneous measurement of surface proteins and gene expression within single cells using oligo-conjugated antibodies offers high-resolution snapshots of complex cell populations. Signal from oligo-conjugated antibodies is quantified by h…
View article: Author response: Improving oligo-conjugated antibody signal in multimodal single-cell analysis
Author response: Improving oligo-conjugated antibody signal in multimodal single-cell analysis Open
View article: JAK3 Is Expressed in the Nucleus of Malignant T Cells in Cutaneous T Cell Lymphoma (CTCL)
JAK3 Is Expressed in the Nucleus of Malignant T Cells in Cutaneous T Cell Lymphoma (CTCL) Open
Perturbation in JAK-STAT signaling has been reported in the pathogenesis of cutaneous T cell lymphoma (CTCL). JAK3 is predominantly associated with the intra-cytoplasmic part of IL-2Rγc located in the plasma membrane of hematopoietic cells…
View article: Inhibition of succinate dehydrogenase activity impairs human T cell activation and function
Inhibition of succinate dehydrogenase activity impairs human T cell activation and function Open
T cell activation is intimately linked to metabolism, as distinct metabolic requirements support the functional and phenotypical differences between quiescent and activated T cells. Metabolic transition from mitochondrial oxidative phospho…
View article: Discrete Immune Response Signature to SARS-CoV-2 mRNA Vaccination Versus Infection
Discrete Immune Response Signature to SARS-CoV-2 mRNA Vaccination Versus Infection Open
View article: Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma
Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma Open
Cutaneous T-cell lymphoma (CTCL) comprises a group of lymphoproliferative diseases characterized by the accumulation of malignant T cells in chronically inflamed skin lesions. In early stages, the disease presents as skin patches or plaque…