Terry R. Suk
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View article: A stress-dependent TDP-43 SUMOylation program preserves neuronal function
A stress-dependent TDP-43 SUMOylation program preserves neuronal function Open
View article: A stress-dependent TDP-43 SUMOylation program preserves neuronal function
A stress-dependent TDP-43 SUMOylation program preserves neuronal function Open
Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are overwhelmingly linked to TDP-43 dysfunction. Mutations in TDP-43 are rare, indicating that the progressive accumulation of exogenous factors – such as cellular stres…
View article: A Versatile Strategy for Genetic Manipulation of Cajal–Retzius Cells in the Adult Mouse Hippocampus
A Versatile Strategy for Genetic Manipulation of Cajal–Retzius Cells in the Adult Mouse Hippocampus Open
Cajal–Retzius (CR) cells are transient neurons with long-lasting effects on the architecture and circuitry of the neocortex and hippocampus. Contrary to the prevailing assumption that CR cells completely disappear in rodents shortly after …
View article: Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain
Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain Open
View article: Characterizing the differential distribution and targets of Sumo paralogs in the mouse brain
Characterizing the differential distribution and targets of Sumo paralogs in the mouse brain Open
SUMOylation is an evolutionarily conserved and essential mechanism whereby Small Ubiquitin Like Modifiers, or SUMO proteins (Sumo in mice), are covalently bound to protein substrates in a highly dynamic and reversible manner. SUMOylation i…
View article: Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation
Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation Open
A growing body of evidence suggests that nuclear alpha-synuclein (αSyn) plays a role in the pathogenesis of Parkinson’s disease (PD). However, this question has been difficult to address as controlling the localization of αSyn in experimen…
View article: Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation
Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation Open
Dataset for all quantification performed in the affiliated manuscript.
View article: Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation
Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation Open
Dataset for all quantification performed in the affiliated manuscript.
View article: Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor dysfunction and cortical atrophy, independent of protein aggregation
Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor dysfunction and cortical atrophy, independent of protein aggregation Open
Background A growing body of evidence suggests that nuclear alpha-synuclein (αSyn) plays a role in the pathogenesis of Parkinson’s disease (PD). However, this question has been difficult to address as controlling the localization of αSyn i…
View article: The role of TDP-43 mislocalization in amyotrophic lateral sclerosis
The role of TDP-43 mislocalization in amyotrophic lateral sclerosis Open