Explanipedia

Interleukin-33 coordinates a microglial phagocytic response and limits corticothalamic excitability and seizure susceptibility Open

Rafael Taeho Han, Ilia D. Vainchtein, Johannes C. M. Schlachetzki, Frances S. Cho, Leah C. Dorman , et al. · 2021

Summary Microglia are key remodelers of neuronal synapses during brain development, but the mechanisms that regulate this process and its ultimate impact on neural circuit function are not well defined. We previously identified the IL-1 fa…

Neuronal activity in the glioma microenvironment Open

Tessa Johung, Michelle Monje · 2017

HGG-20. NEURONAL ACTIVITY PROMOTES PEDIATRIC GLIOMA INVASION Open

Tessa Johung, Kathryn R. Taylor, Humsa S. Venkatesh, Anna C. Geraghty, Michelle Monje · 2017

The diffusely infiltrating nature of pediatric high-grade glioma (pHGG) is a characteristic hallmark of this disease and represents a major contributor to the dire prognosis seen for pHGG of all neuroanatomical locations, most notably in H…

Diffuse Intrinsic Pontine Glioma: New Pathophysiological Insights and Emerging Therapeutic Targets Open

Tessa Johung, Michelle Monje · 2016

Background: Diffuse Intrinsic Pontine Glioma (DIPG) is the leading cause of brain tumor-related death in children, with median survival of less than one year. Despite decades of clinical trials, there has been no improvement in prognosis s…

Erratum: Functionally defined therapeutic targets in diffuse intrinsic pontine glioma Open

Catherine S. Grasso, Yujie Tang, Nathalène Truffaux, Noah Berlow, Lining Liu , et al. · 2015

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma Open

Catherine S. Grasso, Yujie Tang, Nathalène Truffaux, Noah Berlow, Lining Liu , et al. · 2015

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion Open

Humsa S. Venkatesh, Tessa Johung, Viola Caretti, Alyssa Noll, Yujie Tang , et al. · 2015

BT-02 * FUNCTIONALLY-DEFINED THERAPEUTIC TARGETS IN DIFFUSE INTRINSIC PONTINE GLIOMA Open

C. S. Grasso, Yujie Tang, Nathalène Truffaux, Noah Berlow, Li Liu , et al. · 2015

Diffuse Intrinsic Pontine Glioma (DIPG) is a universally fatal childhood cancer. Here, we performed a chemical screen in patient-derived DIPG cell cultures along with RNAseq expression analysis and integrated computational modeling to iden…

HG-04 * NEURONAL ACTIVITY-REGULATED SECRETION OF NEUROLIGIN-3 PROMOTES GLIOMA GROWTH Open

Humsa S. Venkatesh, Tessa Johung, Viola Caretti, Andreas Noll, Hannes Vogel , et al. · 2015

Active neurons exert a mitogenic effect on normal neural precursor and oligodendroglial precursor cells, the putative cellular origins for high-grade glioma (HGG). We demonstrate that active neurons similarly promote HGG proliferation and …

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