Tetsuhiro Kikuchi
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View article: Transplantation of Human iPS Cell-derived Cerebral Cortical Neurons Promotes Fine Motor Recovery in a Female Mouse Model of Ischemic Stroke
Transplantation of Human iPS Cell-derived Cerebral Cortical Neurons Promotes Fine Motor Recovery in a Female Mouse Model of Ischemic Stroke Open
Background Stroke is a leading global health concern, with cerebral infarction accounting for 62% of cases. Despite advances in acute-phase treatments, functional impairments such as motor deficits remain prevalent. This study investigates…
View article: Control of immune response in an iPSC-based allogeneic cell therapy clinical trial for Parkinson’s disease
Control of immune response in an iPSC-based allogeneic cell therapy clinical trial for Parkinson’s disease Open
Because the central nervous system (CNS) is an immune-privileged organ, it requires different immunosuppression strategies for cell therapies using induced pluripotent stem cells (iPSCs) compared with ones for organ transplantations. We re…
View article: Induction and long-term maintenance of hindbrain-like neural stem cells in xeno- and basic fibroblast growth factor-free conditions
Induction and long-term maintenance of hindbrain-like neural stem cells in xeno- and basic fibroblast growth factor-free conditions Open
Neurons exhibit region-specific identities corresponding to functional distinctions across different brain areas. Region-restricted neural stem cells (NSCs) have previously been generated from pluripotent stem cells; however, maintaining t…
View article: Progranulin enhances the engraftment of transplanted human iPS cell-derived cerebral neurons
Progranulin enhances the engraftment of transplanted human iPS cell-derived cerebral neurons Open
Cerebral organoids (COs) in cell replacement therapy offer a viable approach to reconstructing neural circuits for individuals suffering from stroke or traumatic brain injuries. Successful transplantation relies on effective engraftment an…
View article: Cryopreservation of Induced Pluripotent Stem Cell-Derived Dopaminergic Neurospheres for Clinical Application
Cryopreservation of Induced Pluripotent Stem Cell-Derived Dopaminergic Neurospheres for Clinical Application Open
Background: Pluripotent stem cell (PSC)-derived dopaminergic (DA) neurons are an expected source of cell therapy for Parkinson’s disease. The transplantation of cell aggregates or neurospheres, instead of a single cell suspension has sever…
View article: Preparation of biological samples for the recording of electrophysiological signals using high-density microelectrode arrays
Preparation of biological samples for the recording of electrophysiological signals using high-density microelectrode arrays Open
The use of high-density microelectrode arrays (HD-MEAs) provides a promising approach for electrophysiological studies targeted at understanding of brain functions, profiling of neurodegenerative diseases, and drug screening. Here we prese…
View article: Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level
Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level Open
Chronic imaging of neuronal networks in vitro has provided fundamental insights into mechanisms underlying neuronal function. Current labeling and optical imaging methods, however, cannot be used for continuous and long-term recordings of …
View article: Axonal Extensions along Corticospinal Tracts from Transplanted Human Cerebral Organoids
Axonal Extensions along Corticospinal Tracts from Transplanted Human Cerebral Organoids Open
The reconstruction of lost neural circuits by cell replacement is a possible treatment for neurological deficits after cerebral cortex injury. Cerebral organoids can be a novel source for cell transplantation, but because the cellular comp…
View article: Clinically compatible differentiation protocol for human pluripotent stem cell-derived dopaminergic progenitor cells
Clinically compatible differentiation protocol for human pluripotent stem cell-derived dopaminergic progenitor cells Open
Cell replacement therapy with human pluripotent stem cells has the potential to be a new therapy for Parkinson’s disease (PD). This protocol induces human induced pluripotent stem cells (iPSCs) to dopaminergic progenitor cells (DAPs) as cl…
View article: Zonisamide promotes survival of human‐induced pluripotent stem cell‐derived dopaminergic neurons in the striatum of female rats
Zonisamide promotes survival of human‐induced pluripotent stem cell‐derived dopaminergic neurons in the striatum of female rats Open
The transplantation of dopaminergic (DA) progenitors derived from pluripotent stem cells improves the behavior of Parkinson's disease model animals. However, the survival of DA progenitors is low, and the final yield of DA neurons is only …
View article: Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level
Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level Open
Chronic imaging of neuronal networks in vitro has provided fundamental insights into mechanisms underlying neuronal function. Existing labeling and optical imaging methods, however, cannot be used for continuous and long-term recordings of…
View article: MHC matching improves engraftment of iPSC-derived neurons in non-human primates
MHC matching improves engraftment of iPSC-derived neurons in non-human primates Open
The banking of human leukocyte antigen (HLA)-homozygous-induced pluripotent stem cells (iPSCs) is considered a future clinical strategy for HLA-matched cell transplantation to reduce immunological graft rejection. Here we show the efficacy…