Explanipedia

ABS1091 THE EFFECTS OF GLUCOCORTICOID ON TREATMENT COURSE IN PATIENTS WITH DIFFICULT TO TREAT RHEUMATOID ARTHRITIS Open

S. Anno, T. Okano, K. Mamoto, Y. Yamada, Kumi Orita , et al. · 2025

ABS0812 COMPARISON OF THE CLINICAL EFFECTS OF JAK INHIBITORS AND IL-6 INHIBITORS IN THE PATIENTS WITH RHEUMATOID ARTHRITIS Open

K. Mamoto, Tadashi Okano, Y. Yamada, Toshihisa Kojima, S. Anno , et al. · 2025

Long-term d-allose administration ameliorates age-related cognitive impairment and loss of bone strength in male mice Open

Tomoya Shintani, Shuichi Yanai, Akane Kanasaki, Tetsuo Iida, Shogo Endo · 2024

Age-related physical and cognitive decline may be ameliorated by consuming functional foods. d-Allose, reported to have multiple health benefits, may temper aging phenotypes, particularly brain function. We investigated whether d-allose su…

Metabolic Profiling of Rat Kidney Tissue Following Administration of D-Allulose Open

Akane Kanasaki, Misato Niibo, Tetsuo Iida · 2024

D-Allulose (D-psicose) is a rare sugar and a C-3 epimer of D-fructose. D-Allulose has been reported to have several health benefits via its alteration of both glucose and lipid metabolism. It was previously reported that D-allulose alters …

Anti-Obesity Effects of Dietary d-Allulose and Medium-Chain Triglycerides in High-Fat Diet-Fed Rats Open

T. Matsuo, Chihiro Yokoyama, Takako Yamada, Tetsuo Iida, Susumu Mochizuki , et al. · 2024

Long-term D-Allose Administration Favorably Alters the Intestinal Environment in Aged Male Mice Open

Tomoya Shintani, Shuichi Yanai, Akane Kanasaki, Misuzu Tanaka, Tetsuo Iida , et al. · 2022

D-Allose, a C3 epimer of D-glucose, has potential to improve human health as a functional food. However, its effect on the intestinal environment remains unknown. Aged humans progressively express changes in the gut, some of which deleteri…

Combined effects of exercise training and <i>D</i>‐allulose intake on endurance capacity in mice Open

Takamasa Tsuzuki, Ryō Suzuki, Risa Kajun, Takako Yamada, Tetsuo Iida , et al. · 2022

This study investigated the combined effects of exercise training and D ‐allulose intake on endurance capacity in mice. Male C57BL/6J mice were fed either a control diet (Con) or a 3% D ‐allulose diet (Allu) and further divided into the se…

d-allulose protects against diabetic nephropathy progression in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes Open

Misato Niibo, Akane Kanasaki, Tetsuo Iida, Keisuke Ohnishi, Taro Ozaki , et al. · 2022

d -allulose is a rare sugar that has been reported to possess anti-hyperglycemic effects. In the present study, we hypothesized that d -allulose is effective in attenuating the progression of diabetic nephropathy in the Otsuka Long-Evans T…

d-Allulose Improves Endurance and Recovery from Exhaustion in Male C57BL/6J Mice Open

Bingyang Liu, Yang Gou, Takamasa Tsuzuki, Takako Yamada, Tetsuo Iida , et al. · 2022

d-Allulose, a rare sugar, improves glucose metabolism and has been proposed as a candidate calorie restriction mimetic. This study aimed to investigate the effects of d-allulose on aerobic performance and recovery from exhaustion and compa…

Dietary D-Allulose Reduces Body Fat Accumulation in Rats with and without Medium-Chain Triacylglycerol Supplementation Open

Tatsuhiro Matsuo, Takako Yamada, Tetsuo Iida, Susumu Mochizuki, Akihide Yoshihara , et al. · 2022

d-Allulose (d-psicose) is a rare sugar, that contains no calories and exhibits 70% relative sweetness when compared with sucrose. Recently, several studies have demonstrated the anti-obesity effect of d-allulose, mediated by suppressing li…

d-Allulose Ameliorates Skeletal Muscle Insulin Resistance in High-Fat Diet-Fed Rats Open

Yang Gou, Bingyang Liu, Mengyao Cheng, Takako Yamada, Tetsuo Iida , et al. · 2021

Background: d-Allulose is a rare sugar with antiobesity and antidiabetic activities. However, its direct effect on insulin sensitivity and the underlying mechanism involved are unknown. Objective: This study aimed to investigate the effect…

Investigation of d-allulose effects on high-sucrose diet-induced insulin resistance via hyperinsulinemic-euglycemic clamps in rats Open

Yukie Natsume, Takako Yamada, Tetsuo Iida, Nobuaki Ozaki, Yang Gou , et al. · 2021

d-Allose is absorbed via sodium-dependent glucose cotransporter 1 (SGLT1) in the rat small intestine Open

Kunihiro Kishida, Tetsuo Iida, Takako Yamada, Yukiyasu Toyoda · 2021

Effects of D-allulose on glucose tolerance and insulin response to a standard oral sucrose load: results of a prospective, randomized, crossover study Open

Francesco Franchi, Dmitry Yaranov, Fabiana Rollini, Andrea Rivas, Jose Rivas Rios , et al. · 2021

Introduction Current dietary guidelines recommend limiting sugar intake for the prevention of diabetes mellitus (DM). Reduction in sugar intake may require sugar substitutes. Among these, D-allulose is a non-calorie rare monosaccharide wit…

The influence of long-term ingestion of D-allulose in hypercholesterolemia patients under statin therapy Open

Misuzu Tanaka, Akane Kanasaki, Noriko Hayashi, Tetsuo Iida, Koji Murao · 2021

D-allulose is a non-caloric natural sugar with health benefits. A few clinical trials with continuous D-allulose intake have been reported; one indicated significant increase in low-density lipoprotein cholesterol (LDL-C) levels, though th…

d-Allulose enhances uptake of HDL-cholesterol into rat’s primary hepatocyte via SR-B1 Open

Akane Kanasaki, Tetsuo Iida, Koji Murao, Bungo Shirouchi, Masao Sato · 2020

Safety and efficacy of a 48-week long-term ingestion of D-allulose in subjects with high LDL cholesterol levels Open

Misuzu Tanaka, Akane Kanasaki, Noriko Hayashi, Tetsuo Iida, Koji Murao · 2020

D-allulose is one of the rare sugars with almost zero calories and several health benefits. Previous studies have reported the safety of D-allulose in normal, overweight/obese, and diabetic humans. However, one study reported significant i…

Effects of Chocolate Containing D-allulose on Postprandial Lipid and Carbohydrate Metabolism in Young Japanese Women Open

Misuzu Tanaka, Noriko Hayashi, Tetsuo Iida, Kaori Kuzawa, Michitaka Naito · 2020

D-allulose is an almost zero calorie sweetener with 70% sweetness of sucrose, and has some health benefits. Here, we conducted a small-scale human trial with a single blind cross over design in 8 young healthy Japanese women to assess the …

Dietary d-allulose alters cholesterol metabolism in Golden Syrian hamsters partly by reducing serum PCSK9 levels Open

Akane Kanasaki, Zhe Jiang, Takuya Mizokami, Bungo Shirouchi, Tetsuo Iida , et al. · 2019

Recovery of increased weights of the liver and kidneys by cessation of D-allulose feeding in Wistar rats Open

Masaru Ochiai, Kei Ohkubo, Masako Nakamura, Takako Yamada, Tetsuo Iida , et al. · 2019

Rare sugar D-allulose prevents obesity; however, an excessive and continuous intake of D-allulose may induce weight increases in the liver and kidney without apparent pathological and functional abnormalities. Conversely, there has not bee…

Secretion of GLP-1 but not GIP is potently stimulated by luminal d -Allulose ( d -Psicose) in rats Open

Masaki Hayakawa, Tohru Hira, Masako Nakamura, Tetsuo Iida, Yuka Kishimoto , et al. · 2018

Intra-Abdominal Hemorrhage Caused by Ruptured Aneurysm of the Left Gastric Artery : A Case Report (Case Report) Open

Funamizu Naotake, Yukio Nakabayashi, Muneyuki Koyama, Masamichi Momose, Yuki Hiramoto , et al. · 2017

Effect of Ingestion of Rare Sugar Syrup on the Blood Glucose Response in Humans Open

Takako Yamada, Tomoya Shintani, Tetsuo Iida, Yuka Kishimoto, Kazuhiro Okuma · 2017

ブドウ糖果糖液糖のアルカリ異性化である希少糖含有シロップ摂取による血糖応答に及ぼす影響をヒト試験で評価した。グリセミック・インデックス (GI) 試験を行った結果, 希少糖含有シロップのGI値は49であった。次に, 空腹時血糖値126 mg/dL未満の成人50名を対象にランダム化二重盲検プラセボ対照クロスオーバーによる低用量単回試験を行った。ショ糖6 gまたは希少糖含有シロップ8.8 g (同量のブドウ糖含有量) をコーヒーに溶解し摂取させ, 120分までの血糖値およびイン…

Comparison of Anti-Obesity Effect between Two Types of Syrup Containing Rare Sugars in Wistar Rats Open

Masaru Ochiai, Kohei Misaki, Takako Yamada, Tetsuo Iida, Kazuhiro Okuma , et al. · 2017

D-Allulose-containing rare sugar sweeteners have been categorized into two types, rare sugar syrup (RSS), consisting of 4 rare monosaccharides, and modified glucose syrup (MGS), rich in D-allulose, which was previously referred to D-psicos…

Safety Evaluation of Rare Sugar Syrup: Single-dose Oral Toxicity in Rats, Reverse Mutation Assay, Chromosome Aberration Assay, and Acute Non-Effect Level for Diarrhea of a Single Dose in Humans Open

Takako Yamada, Tetsuo Iida, Satoshi Takamine, Noriko Hayashi, Kazuhiro Okuma · 2015

The safety of rare sugar syrup obtained from high-fructose corn syrup under slightly alkaline conditions was studied. Mutagenicity of rare sugar syrup was assessed by a reverse mutation assay using Salmonella typhimurium and Escherichia co…

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