Tetsuo Kon
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View article: Giant genome of the vampire squid reveals the derived state of modern octopod karyotypes
Giant genome of the vampire squid reveals the derived state of modern octopod karyotypes Open
Ancient evolutionary transitions in animal chromosomal complements and their phenotypic impacts remain understudied. Few systems exist where these events can be dissected into individual steps. In coleoid cephalopods (octopus, squid, cuttl…
View article: Giant genome of the vampire squid reveals the derived state of modern octopod karyotypes
Giant genome of the vampire squid reveals the derived state of modern octopod karyotypes Open
Why some animal groups retain ancestral chromosomal complements while others change significantly is a fundamental question in evolutionary genomics. Few systems exist where accumulations of chromosomal changes can be studied in the contex…
View article: Chromosome-level genome assembly of the doctor fish (Garra rufa)
Chromosome-level genome assembly of the doctor fish (Garra rufa) Open
Garra rufa, or doctor fish, is a small cyprinid known for its high-temperature tolerance and its use in ichthyotherapy. Recently, this trait has gained interest as a model for human diseases, including infections and cancer xenografts, tho…
View article: A Chromosome-Scale Genome of Nanomia septata Reveals Extensive Rearrangement But No Clear Driver of the Unique Colony-Level Organization of Siphonophores
A Chromosome-Scale Genome of Nanomia septata Reveals Extensive Rearrangement But No Clear Driver of the Unique Colony-Level Organization of Siphonophores Open
Siphonophores (Cnidaria:Hydrozoa) are pelagic colonial marine invertebrates with many highly specialized bodies (zooids) within a single colony. Their unique biology and ecological importance have made them of particular interest. Recent w…
View article: Subtelomeric repeat expansion in Hydractinia symbiolongicarpus chromosomes
Subtelomeric repeat expansion in Hydractinia symbiolongicarpus chromosomes Open
Despite the striking conservation of animal chromosomes, their repetitive element complements are vastly diverse. Only recently, high quality chromosome-level genome assemblies enabled identification of repeat compositions along a broad ra…
View article: Potential of Garra rufa as a novel high-temperature resistant model fish: a review on current and future approaches
Potential of Garra rufa as a novel high-temperature resistant model fish: a review on current and future approaches Open
Garra rufa , commonly known as the “doctor fish”, is a freshwater cyprinid native to warm regions of the Middle East. Since the late twentieth century, it has been widely utilized in spas for alternative therapeutics and fish pedicures (or…
View article: HSymV2.0: a chromosome-level genome assembly of Hydractinia symbiolongicarpus
HSymV2.0: a chromosome-level genome assembly of Hydractinia symbiolongicarpus Open
We constructed the first chromosome-level genome assembly of Hydractinia symbiolongicarpus (the HSymV2.0 assembly) using PacBio HiFi long-read sequencing and Hi-C scaffolding. The HSymV2.0 assembly (NCBI accession number: JARBIS000000000) …
View article: Expansion of a single Helitron subfamily in<i>Hydractinia symbiolongicarpus</i>suggests a shared mechanism of cnidarian chromosomal extension
Expansion of a single Helitron subfamily in<i>Hydractinia symbiolongicarpus</i>suggests a shared mechanism of cnidarian chromosomal extension Open
Helitrons are rolling-circle transposons that amplify through rolling-circle replication mechanism. Since Helitrons were relatively recently identified, their impact on genome evolution is still not fully understood. Here, we describe that…
View article: The dynamic genomes of Hydra and the anciently active repeat complement of animal chromosomes
The dynamic genomes of Hydra and the anciently active repeat complement of animal chromosomes Open
Many animal genomes are characterized by highly conserved chromosomal homologies that pre-date the ancient origin of this clade. Despite such conservation, the evolutionary forces behind the retention, expansion, and contraction of chromos…
View article: Chromosome-level genome assembly of <i>Hydractinia symbiolongicarpus</i>
Chromosome-level genome assembly of <i>Hydractinia symbiolongicarpus</i> Open
Hydractinia symbiolongicarpus is a pioneering model organism for stem cell biology, being one of only a few animals with adult pluripotent stem cells (known as i-cells). However, the unavailability of a chromosome-level genome assembly has…
View article: Single-cell RNA-seq analysis of the goldfish retina
Single-cell RNA-seq analysis of the goldfish retina Open
This is the single-cell RNA-seq data of the goldfish retina.
View article: Whole-genome sequencing of endangered Zhoushan cattle suggests its origin and the association of MC1R with black coat colour
Whole-genome sequencing of endangered Zhoushan cattle suggests its origin and the association of MC1R with black coat colour Open
Zhoushan cattle are an endangered cattle breed in the Zhoushan islands in China. Since Zhoushan cattle have been bred in isolation, they show unique characteristics, such as dark black coat colour. However, no studies have been conducted o…
View article: Whole-genome resequencing of large yellow croaker (Larimichthys crocea) reveals the population structure and signatures of environmental adaptation
Whole-genome resequencing of large yellow croaker (Larimichthys crocea) reveals the population structure and signatures of environmental adaptation Open
Large yellow croaker is an economically important fish in China and East Asia. Despite its economic importance, genome-wide adaptions of domesticated large yellow croaker are largely unknown. Here, we performed whole-genome resequencing of…
View article: Origin and evolution of the <i>Rax</i> homeobox gene by comprehensive evolutionary analysis
Origin and evolution of the <i>Rax</i> homeobox gene by comprehensive evolutionary analysis Open
Rax is one of the key transcription factors crucial for vertebrate eye development. In this study, we conducted comprehensive evolutionary analysis of Rax. We found that Bilateria and Cnidaria possess Rax, but Placozoa, Porifera, and Cteno…
View article: Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development
Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development Open
Otx family homeoproteins Otx2 and Crx are expressed in photoreceptor precursor cells and bind to the common DNA-binding consensus sequence, but these two proteins have distinct functions in retinal development. To examine the functional su…
View article: Goldfish: an old and new model system to study vertebrate development, evolution and human disease
Goldfish: an old and new model system to study vertebrate development, evolution and human disease Open
The goldfish (Carassius auratus) is a domesticated cyprinid teleost closely related to the crucian carp. Goldfish domestication occurred in South China around 1,000 years ago. At least 180 variants and 70 genetically established strains ar…
View article: Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity
Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity Open
In the vertebrate retina, cone photoreceptors play crucial roles in photopic vision by transmitting light-evoked signals to ON- and/or OFF-bipolar cells. However, the mechanisms underlying selective synapse formation in the cone photorecep…
View article: Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity
Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity Open
Significance Each retinal rod and cone photoreceptor cell subtype expresses a distinct set of genes including the genes encoding phototransduction components such as opsins and transducins. This subtype-specific gene expression is essentia…
View article: DNA Damage Response Is Involved in the Developmental Toxicity of Mebendazole in Zebrafish Retina
DNA Damage Response Is Involved in the Developmental Toxicity of Mebendazole in Zebrafish Retina Open
Intestinal helminths cause iron-deficiency anemia in pregnant women, associated with premature delivery, low birth weight, maternal ill health, and maternal death. Although benzimidazole compounds such as mebendazole (MBZ) are highly effic…
View article: Anatomical hepatectomy for liver metastasis from rectal adenocarcinoma presenting with intrabiliary extension: a case report
Anatomical hepatectomy for liver metastasis from rectal adenocarcinoma presenting with intrabiliary extension: a case report Open
Liver metastases from colorectal carcinoma commonly form nodular lesions in the liver parenchyma. We report a case of liver metastasis from rectal adenocarcinoma that extended predominantly into the bile duct. A 62-year-old Japanese man un…