Tetsuya Iizuka
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View article: CMOS Implementation of Field Programmable Spiking Neural Network for Hardware Reservoir Computing
CMOS Implementation of Field Programmable Spiking Neural Network for Hardware Reservoir Computing Open
The increasing complexity and energy demands of large-scale neural networks, such as Deep Neural Networks (DNNs) and Large Language Models (LLMs), challenge their practical deployment in edge applications due to high power consumption, are…
View article: Production of Transgenic Silkworm Using Anti-Serum Against Diapause Hormone in Diapause Strains of Silkworm, Bombyx mori
Production of Transgenic Silkworm Using Anti-Serum Against Diapause Hormone in Diapause Strains of Silkworm, Bombyx mori Open
In general, the silkworm, Bombyx mori, has a diapause trait in its eggs. Therefore, transgenic silkworm can be produced by embryonic microinjection using eggs laid by a non-diapause strain in B. mori. In this study, we performed microinjec…
View article: Hardware-friendly implementation of physical reservoir computing with CMOS-based time-domain analog spiking neurons
Hardware-friendly implementation of physical reservoir computing with CMOS-based time-domain analog spiking neurons Open
This paper introduces an analog spiking neuron that utilizes time-domain information, i.e. a time interval of two signal transitions and a pulse width, to construct a spiking neural network (SNN) for a hardware-friendly physical reservoir …
View article: An ATP-binding cassette subfamily C is crucial for flavonoid sequestration in the domestic silkworm,<i>Bombyx mori</i>
An ATP-binding cassette subfamily C is crucial for flavonoid sequestration in the domestic silkworm,<i>Bombyx mori</i> Open
Some herbivorous insects have evolved sequestration mechanisms, the ability to take up and accumulate plant secondary metabolites for their own benefit. The domestic silkworm, Bombyx mori , and its wild ancestor, B. mandarina , take up fla…
View article: N-glycan-modified α-L-iduronidase produced by transgenic silkworms ameliorates clinical signs in a Japanese macaque with mucopolysaccharidosis I
N-glycan-modified α-L-iduronidase produced by transgenic silkworms ameliorates clinical signs in a Japanese macaque with mucopolysaccharidosis I Open
Background Mucopolysaccharidosis type I (MPS I) is an inherited lysosomal storage disorder (LSD) caused by recessive mutations in the α-L-iduronidase ( IDUA ) gene. Enzyme replacement therapy (ERT) utilizing terminal mannose-6-phosphate (M…
View article: Fully-Standard-Cell-Based Synthesizable Charge-Redistribution SAR ADCs and P&R-Based Layout Automation Framework
Fully-Standard-Cell-Based Synthesizable Charge-Redistribution SAR ADCs and P&R-Based Layout Automation Framework Open
This paper presents two fully standard-cell-based synthesizable Successive Approximation Register Analog-to-Digital Converters (SAR ADCs) and the automated layout generation framework. The 1st design is an 8-bit charge-redistribution SAR A…
View article: An All-Standard-Cell-Based Synthesizable SAR ADC with Inverter-Cell-Based Capacitive DAC
An All-Standard-Cell-Based Synthesizable SAR ADC with Inverter-Cell-Based Capacitive DAC Open
This paper proposes an 8-bit synthesizable SAR ADC with inverter-cell-based capacitive digital-to-analog converters (CDACs). An inverter-cell-based capacitor is proposed by connecting the supply and ground ports of the inverter cells toget…
View article: Taming Prolonged Ionic Drift–Diffusion Dynamics for Brain‐Inspired Computation
Taming Prolonged Ionic Drift–Diffusion Dynamics for Brain‐Inspired Computation Open
Recent advances in neural network‐based computing have enabled human‐like information processing in areas such as image classification and voice recognition. However, many neural networks run on conventional computers that operate at GHz c…
View article: Egg Cooling After Oviposition Extends the Permissive Period for Microinjection-Mediated Genome Modification in Bombyx mori
Egg Cooling After Oviposition Extends the Permissive Period for Microinjection-Mediated Genome Modification in Bombyx mori Open
In general, transgenesis efficiency is largely dependent on the developmental status of eggs for microinjection. We investigated whether the relationship between transgenesis efficiency and cooling eggs in silkworms, Bombyx mori, affects t…
View article: Hardware-Friendly Implementation of Physical Reservoir Computing with CMOS-based Time-domain Analog Spiking Neurons
Hardware-Friendly Implementation of Physical Reservoir Computing with CMOS-based Time-domain Analog Spiking Neurons Open
This paper introduces an analog spiking neuron that utilizes time-domain information, i.e., a time interval of two signal transitions and a pulse width, to construct a spiking neural network (SNN) for a hardware-friendly physical reservoir…
View article: Real-time information processing via volatile resistance change in scalable protonic devices
Real-time information processing via volatile resistance change in scalable protonic devices Open
Biological neural systems operate on multiple time scales, enabling real-time interaction with their environment. However, replicating this in electronic systems is challenging, as scalable devices that operate on similar time scales, part…
View article: N-glycan-modified α-L-iduronidase produced by transgenic silkworms ameliorates symptoms in a Japanese macaque with mucopolysaccharidosis I
N-glycan-modified α-L-iduronidase produced by transgenic silkworms ameliorates symptoms in a Japanese macaque with mucopolysaccharidosis I Open
Mucopolysaccharidosis type I (MPS I) is an inherited lysosomal storage disorder (LSD) caused by recessive mutations in the α-L-iduronidase (IDUA) gene. Enzyme replacement therapy (ERT) utilizing terminal mannose 6-phosphate (M6P)-carrying …
View article: A Single Ring-Oscillator-Based Test Structure for Timing Characterization of Dynamic Circuit
A Single Ring-Oscillator-Based Test Structure for Timing Characterization of Dynamic Circuit Open
Dynamic circuit is extensively used where high speed is required such as critical paths in digital and analog/mixed-signal circuits, yet it has not been successfully characterized and integrated into the digital design flows as its charact…
View article: Cry Toxins Use Multiple ATP-Binding Cassette Transporter Subfamily C Members as Low-Efficiency Receptors in Bombyx mori
Cry Toxins Use Multiple ATP-Binding Cassette Transporter Subfamily C Members as Low-Efficiency Receptors in Bombyx mori Open
Recent studies have suggested that ABC transporters are the main receptors of Cry toxins. However, the receptors of many Cry toxins have not been identified. In this study, we used a heterologous cell expression system to identify Bombyx m…
View article: A Fractional-N Ring PLL Using Harmonic-Mixer-Based Dual-Feedback and Split-Feedback Frequency Division With Phase-Domain Filtering
A Fractional-N Ring PLL Using Harmonic-Mixer-Based Dual-Feedback and Split-Feedback Frequency Division With Phase-Domain Filtering Open
A phase-locked loop (PLL) employing a split-feedback divider and nested-PLL-based phase-domain low-pass filter (PDLPF) within the harmonic-mixer (HM)-based dual-feedback architecture is presented in this article. The proposed architecture …
View article: A major endogenous glycoside hydrolase mediating quercetin uptake in Bombyx mori
A major endogenous glycoside hydrolase mediating quercetin uptake in Bombyx mori Open
Quercetin is a common plant flavonoid which is involved in herbivore–plant interactions. Mulberry silkworms (domestic silkworm, Bombyx mori , and wild silkworm, Bombyx mandarina ) take up quercetin from mulberry leaves and accumulate the m…
View article: Systematic Equation-Based Design of a 10-Bit, 500-MS/s Single-Channel SAR A/D Converter With 2-GHz Resolution Bandwidth
Systematic Equation-Based Design of a 10-Bit, 500-MS/s Single-Channel SAR A/D Converter With 2-GHz Resolution Bandwidth Open
A 10-b self-timed SAR A/D converter is designed in 28-nm FDSOI CMOS to convert at 500 MS/s. It maintains this effective number of bits across an input bandwidth of 2 GHz, because it will be used as one of eight identical converters in a ti…
View article: 150GHz Fundamental Oscillator Utilizing Transmission-Line-Based Inter-Stage Matching in 130nm SiGe BiCMOS Technology
150GHz Fundamental Oscillator Utilizing Transmission-Line-Based Inter-Stage Matching in 130nm SiGe BiCMOS Technology Open
A 150 GHz fundamental oscillator employing an inter-stage matching network based on a transmission line is presented in this letter. The proposed oscillator consists of a two-stage common-emitter amplifier loop, whose inter-stage connectio…
View article: Investigation and Improvement on Self-Dithered MASH ΔΣ Modulator for Fractional-N Frequency Synthesis
Investigation and Improvement on Self-Dithered MASH ΔΣ Modulator for Fractional-N Frequency Synthesis Open
Self-dithered digital delta-sigma modulators (DDSMs) are commonly used in fractional-N frequency synthesizers due to their ability to eliminate unwanted spurs from the synthesizer's spectra without requiring additional hardware. However, w…