Tetsuya Imura
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View article: Disease-specific alterations of the enteric nervous system in precancerous colonic mucosa and their implications for mucin regulation
Disease-specific alterations of the enteric nervous system in precancerous colonic mucosa and their implications for mucin regulation Open
The dynamics of enteric glial cells (EGCs), the most prevalent cell type of the enteric nervous system (ENS), remain to be fully elucidated. Here, we analyzed the number and spatial distribution of Sox10 + mucosal EGCs in the human lower g…
Malignant gastrointestinal neuroectodermal tumor of the ileum: A case report and review of imaging characteristics Open
Malignant gastrointestinal neuroectodermal tumors (MGNETs) are extremely rare malignant mesenchymal tumors derived from ectodermal neural cells of the gastrointestinal tract that most commonly arise in the small intestine. Preoperative dia…
View article: Activation of S1PR2 on macrophages and the hepatocyte S1PR2/RhoA/ROCK1/MLC2 pathway in vanishing bile duct syndrome
Activation of S1PR2 on macrophages and the hepatocyte S1PR2/RhoA/ROCK1/MLC2 pathway in vanishing bile duct syndrome Open
Immunologic bile duct destruction is a pathogenic condition associated with vanishing bile duct syndrome (VBDS) after liver transplantation and hematopoietic stem-cell transplantation. As the bile acid receptor sphingosine 1-phosphate rece…
N-acetylglucosamine-6-O sulfation on intestinal mucins prevents obesity and intestinal inflammation by regulating gut microbiota Open
Intestinal mucins play an essential role in the defense against bacterial invasion and the maintenance of gut microbiota, which is instrumental in the regulation of host immune systems; hence, its dysregulation is a hallmark of metabolic d…
Soluble JAM-C Ectodomain Serves as the Niche for Adipose-Derived Stromal/Stem Cells Open
Junctional adhesion molecules (JAMs) are expressed in diverse types of stem and progenitor cells, but their physiological significance has yet to be established. Here, we report that JAMs exhibit a novel mode of interaction and biological …
Serotonin/5-HT1A Signaling in the Neurovascular Unit Regulates Endothelial CLDN5 Expression Open
We previously reported that site-selective claudin-5 (CLDN5) breakdown and protein kinase A (PKA) activation are observed in brain microvessels of schizophrenia, but the underlying molecular basis remains unknown. The 5-HT1 receptors decli…
PKA activation and endothelial claudin-5 breakdown in the schizophrenic prefrontal cortex Open
Schizophrenia is thought to be caused by a combination of genetic and environmental factors; however, its pathogenesis remains largely unknown. Here, we focus on the endothelial tight-junction protein claudin-5 (CLDN5), because the CLDN5 g…