Tetsuya Takahashi
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View article: Methanol Poisoning Without Typical Diagnostic Clues or Standard Antidotes: A Case Report on Clinical Decision-Making
Methanol Poisoning Without Typical Diagnostic Clues or Standard Antidotes: A Case Report on Clinical Decision-Making Open
Methanol poisoning is a potentially life-threatening condition characterized by severe metabolic acidosis and visual disturbances. Early diagnosis may be challenging due to nonspecific symptoms and limited access to diagnostic tools or ant…
View article: Sex Differences in Motor Unit Behavior in Patients With Parkinson's Disease
Sex Differences in Motor Unit Behavior in Patients With Parkinson's Disease Open
The aim of this study was to determine whether there are sex differences in motor unit firing behavior in patients with Parkinson's disease. Twenty‐seven patients with Parkinson's disease (females = 14 [age = 71.1 ± 6.8], males = 13 [age =…
View article: Anatomy of the fumarole field of Hakone Volcano, Japan: Interpretation of its resistivity structure and inferences for the steaming activity and recent hydrothermal eruption
Anatomy of the fumarole field of Hakone Volcano, Japan: Interpretation of its resistivity structure and inferences for the steaming activity and recent hydrothermal eruption Open
View article: Impact of strength training of large muscle groups on quality of life
Impact of strength training of large muscle groups on quality of life Open
Muscle-strengthening activities reduce the risk of various diseases and promote overall health. Physical activities targeting large muscle groups, such as weightlifting or resistance exercises, provide an additional health benefit. The pre…
View article: Clinical and Pathological Features of <scp>FTDP</scp>‐17 with <scp><i>MAPT</i></scp> p.K298_H299insQ Mutation
Clinical and Pathological Features of <span>FTDP</span>‐17 with <span><i>MAPT</i></span> p.K298_H299insQ Mutation Open
Background MAPT is a causative gene in frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP‐17), a hereditary degenerative disease with various clinical manifestations, including progressive supranuclear palsy, corticoba…
View article: Reliability, stability during long-term storage, and intra-individual variation of circulating levels of osteopontin, osteoprotegerin, vascular endothelial growth factor-A, and interleukin-17A
Reliability, stability during long-term storage, and intra-individual variation of circulating levels of osteopontin, osteoprotegerin, vascular endothelial growth factor-A, and interleukin-17A Open
View article: The long-term effects of heated tobacco product exposure on the central nervous system in a mouse model of prodromal Alzheimer's disease
The long-term effects of heated tobacco product exposure on the central nervous system in a mouse model of prodromal Alzheimer's disease Open
View article: Anatomy of the Fumarole Field of Hakone Volcano, Japan: Interpretation of its Resistivity Structure and Inferences for its Steaming Activity and Recent Hydrothermal Eruption
Anatomy of the Fumarole Field of Hakone Volcano, Japan: Interpretation of its Resistivity Structure and Inferences for its Steaming Activity and Recent Hydrothermal Eruption Open
View article: Antibody-recognizing residues 188-211 of TMEM106B exhibit immunohistochemical reactivity with the TMEM106B C-terminal fragment
Antibody-recognizing residues 188-211 of TMEM106B exhibit immunohistochemical reactivity with the TMEM106B C-terminal fragment Open
Accumulation of TMEM106B fibrils composed of cleaved C-terminal fragments (CTF) of transmembrane protein 106B (TMEM106B) has recently been observed in the brains of elderly subjects and individuals with neurodegenerative diseases. To date,…
View article: Corticobasal syndrome presenting Foix-Chavany-Marie syndrome with suggested 4-repeat tauopathy by tau PET
Corticobasal syndrome presenting Foix-Chavany-Marie syndrome with suggested 4-repeat tauopathy by tau PET Open
Background: Corticobasal syndrome (CBS) is a neurodegenerative disease diagnosed based on clinical manifestations such as asymmetrical parkinsonism, limb apraxia, and speech and language impairment. Foix-Chavany-Marie syndrome (FCMS) is a …
View article: The effect of long-term exposure to heated tobacco products on the central nervous system using novel in vivo experimental methods
The effect of long-term exposure to heated tobacco products on the central nervous system using novel in vivo experimental methods Open
Heated tobacco products (HTPs) are new products being promoted by the tobacco industry as having a reduced potential for harm compared with conventional cigarettes. However, there is insufficient information on the health risks of long-ter…
View article: Female “Paradox” in Atrial Fibrillation—Role of Left Truncation Due to Competing Risks
Female “Paradox” in Atrial Fibrillation—Role of Left Truncation Due to Competing Risks Open
Female sex in patients with atrial fibrillation (AF) is a controversial and paradoxical risk factor for stroke—controversial because it increases the risk of stroke only among older women of some ethnicities and paradoxical because it appe…
View article: Predictive factors and clinical impact of ICU-acquired weakness on functional disability in mechanically ventilated patients with COVID-19
Predictive factors and clinical impact of ICU-acquired weakness on functional disability in mechanically ventilated patients with COVID-19 Open
View article: Urban planning policies to promote physical activity in basic municipalities in Japan
Urban planning policies to promote physical activity in basic municipalities in Japan Open
本研究は日本の9都市における、都市計画関連政策を1000 Cities Challengeの指標を用いて身体活動促進の観点から試行的に評価して、各都市の政策の現状を示すことを目的とする。結果として、身体活動促進につながる政策も散見されるが、文面を見る限りでは必ずしも身体活動促進を意識していると判断できない政策も多かった。指標別に見ると、自転車・歩行者インフラの整備についてはすべての市が、雇用分布や街路接続については、どの市も身体活動促進を意識した政策を持たなかった。
View article: Preoperative Serum Cortisol Level Is Predictive of Weight Loss After Laparoscopic Sleeve Gastrectomy in Men with Severe Obesity but Not Women
Preoperative Serum Cortisol Level Is Predictive of Weight Loss After Laparoscopic Sleeve Gastrectomy in Men with Severe Obesity but Not Women Open
Background Bariatric surgery is an effective treatment for severe obesity and its associated medical problems. Preoperative factors that predict postoperative weight loss remain to be fully characterized, however. Methods Anthropometric an…
View article: Case of hereditary Y69H (p.Y89H) transthyretin variant leptomeningeal amyloidosis presenting with drop attacks and recurrent transient language disorder
Case of hereditary Y69H (p.Y89H) transthyretin variant leptomeningeal amyloidosis presenting with drop attacks and recurrent transient language disorder Open
We report a 73-year-old woman who started developing recurrent transient aphasia at the age of 66 years. During the attacks, she was aware she could not understand what was being said and both her spoken and written speech were meaningless…
View article: Biallelic <i>COX10</i> Mutations and <i>PMP22</i> Deletion in a Family With Leigh Syndrome and Hereditary Neuropathy With Liability to Pressure Palsy
Biallelic <i>COX10</i> Mutations and <i>PMP22</i> Deletion in a Family With Leigh Syndrome and Hereditary Neuropathy With Liability to Pressure Palsy Open
These findings suggest that in this family, Leigh syndrome is associated with a mitochondrial respiratory chain complex IV deficiency caused by biallelic COX10 mutations coexisting with HNPP caused by heterozygous PMP22 delet…
View article: Prognostic Impact of Renal Dysfunction at 1-Year Follow-Up on Clinical Outcomes After Percutaneous Coronary Intervention
Prognostic Impact of Renal Dysfunction at 1-Year Follow-Up on Clinical Outcomes After Percutaneous Coronary Intervention Open
Persistent and new-onset renal dysfunction at 1-year follow-up were associated with unfavorable outcomes in patients with CAD who underwent PCI.
View article: Association between winning incentives and citizens’ step counts
Association between winning incentives and citizens’ step counts Open
インセンティブなどの外的動機づけは行動変容を促し、健康維持・増進に必要な身体活動の促進が期待できる。しかし身体活動量に及ぼすインセンティブの効果について報告している国内の研究はほとんどない。本研究では、横浜市の健康施策であるよこはまウォーキングポイント事業を対象に、歩数に与えるインセンティブの効果を分析した。その結果、個人属性を統制した後でも、インセンティブの獲得と歩数の間に正の相関があることがわかった。
View article: Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process
Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process Open
Intracellular amyloid β peptide (Aβ) accumulation has drawn attention in relation to the pathophysiology of Alzheimer’s disease in addition to its extracellular deposition as senile plaque. Cellular uptake of extracellular Aβ is one of the…
View article: Laterality of the activation of the vastus lateralis muscle in females with Parkinson's disease during the medication state compared with healthy controls
Laterality of the activation of the vastus lateralis muscle in females with Parkinson's disease during the medication state compared with healthy controls Open
This study quantified the laterality of motor unit activation properties in females with Parkinson’s disease during force production (low to high-intensity contraction) using high-density surface electromyography. Sixteen females with Park…
View article: QUANTIFYING THE AESTHETIC FOR STREETSCAPES: APPLICATION OF DEEP LEARNING TO ASHIHARA’S AESTHETIC TOWNSCAPE
QUANTIFYING THE AESTHETIC FOR STREETSCAPES: APPLICATION OF DEEP LEARNING TO ASHIHARA’S AESTHETIC TOWNSCAPE Open
This paper discusses the concepts of aesthetic and nonaesthetic in streetscapes. The nonaesthetic refers to physical elements and spatial compositions that make the aesthetic emerge differently depending on the observer who sees them. Usin…
View article: Neuropsychological and regional cerebral blood flow of posterior parietal area features in patients with Parkinson’s disease with mild cognitive impairment
Neuropsychological and regional cerebral blood flow of posterior parietal area features in patients with Parkinson’s disease with mild cognitive impairment Open
This study aimed to clarify associations between neuropsychological scales and regional cerebral blood flow (rCBF) of on 123I-IMP-SPECT in patients with Parkinson's disease with mild cognitive impairment (PD-MCI). Forty-two par…
View article: Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients
Association between the Degree of Pre-Synaptic Dopaminergic Pathway Degeneration and Motor Unit Firing Behavior in Parkinson’s Disease Patients Open
The relationship between motor unit (MU) firing behavior and the severity of neurodegeneration in Parkinson’s disease (PD) is not clear. This study aimed to elucidate the association between degeneration with dopaminergic pathways and MU f…
View article: Quantifying urban streetscapes with deep learning: focus on aesthetic evaluation
Quantifying urban streetscapes with deep learning: focus on aesthetic evaluation Open
The disorder of urban streetscapes would negatively affect people's perception of their aesthetic quality. The presence of billboards on building facades has been regarded as an important factor of the disorder, but its quantification meth…
View article: Case of Neuronal Intranuclear Inclusion Disease With Dynamic Perfusion Changes Lacking Typical Signs on Diffusion-Weighted Imaging
Case of Neuronal Intranuclear Inclusion Disease With Dynamic Perfusion Changes Lacking Typical Signs on Diffusion-Weighted Imaging Open
Neuronal intranuclear inclusion disease (NIID) is a slowly progressive neurodegenerative disorder with a wide range of clinical manifestations, including dementia and peripheral neuropathy.1 NIID is pathologically characterized by eosinoph…
View article: Radiation effects on atherosclerosis in atomic bomb survivors: a cross‐sectional study using structural equation modeling
Radiation effects on atherosclerosis in atomic bomb survivors: a cross‐sectional study using structural equation modeling Open
View article: The Effect of Electrical Muscle Stimulation on Muscle Mass and Balance in Older Adults with Dementia
The Effect of Electrical Muscle Stimulation on Muscle Mass and Balance in Older Adults with Dementia Open
Background: Electrical muscle stimulation (EMS) is effective for increasing physical function. However, there is no evidence regarding the effects of EMS on muscle mass and physical function in older adults with dementia. The aim of the pr…
View article: Practice and Evidence of Skeletal Muscle Assessment in Patients with Heart Failure
Practice and Evidence of Skeletal Muscle Assessment in Patients with Heart Failure Open
心不全患者の骨格筋評価の重要性は，患者の高齢化・重症化とともにますます高まっている．さまざまな骨格筋評価があるが，筋力では膝伸展筋力と握力，筋肉量の推定として上腕と下腿の周囲長と心不全患者の予後の関連が明らかになり，日本からのエビデンスの発信も多い．また，心不全患者の体組成（骨格筋量や体脂肪量）も予後に関係することはわかっており，最近ではphase angleの有用性も数多く検証されてきている．さらに，本論では心不全の骨格筋評価としてのダイナペニアについても解説した．
View article: Krebs von den Lungen 6 decreased in the serum and muscle of <scp>GNE</scp> myopathy patients
Krebs von den Lungen 6 decreased in the serum and muscle of <span>GNE</span> myopathy patients Open
UDP‐ N ‐acetylglucosamine 2‐epimerase/ N ‐acetylmannosamine kinase (GNE) is necessary for sialic acid biosynthesis. GNE myopathy is caused by a defect in GNE , and hyposialylation is a key factor in the pathomechanism of GNE myopathy. Alth…