Tetsuya Tsukamoto
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View article: Supplementary Table 4 from BFAR Promotes Neutrophil Infiltration and Immunosuppressive Reprogramming through the PRP19–YBX1 Axis to Induce Immune Evasion in Gastric Cancer
Supplementary Table 4 from BFAR Promotes Neutrophil Infiltration and Immunosuppressive Reprogramming through the PRP19–YBX1 Axis to Induce Immune Evasion in Gastric Cancer Open
Mass Spectrometry
View article: Supplementary Table 1 from BFAR Promotes Neutrophil Infiltration and Immunosuppressive Reprogramming through the PRP19–YBX1 Axis to Induce Immune Evasion in Gastric Cancer
Supplementary Table 1 from BFAR Promotes Neutrophil Infiltration and Immunosuppressive Reprogramming through the PRP19–YBX1 Axis to Induce Immune Evasion in Gastric Cancer Open
Primers used for plasmid construction
View article: Genomic and clinical parallels between US and Japanese gastric cancers: a propensity score-matched cohort study
Genomic and clinical parallels between US and Japanese gastric cancers: a propensity score-matched cohort study Open
Introduction Gastric cancer incidence, risk factors, and survival outcomes differ significantly between Japan and the United States. These disparities have led to the belief that gastric cancer represents biologically distinct diseases acr…
View article: Micro CT based whole block imaging of asthma induced airway remodeling and co-occurrence of Mycobacterium Avium granulomas: 3-dimensional nondestructive analysis
Micro CT based whole block imaging of asthma induced airway remodeling and co-occurrence of Mycobacterium Avium granulomas: 3-dimensional nondestructive analysis Open
View article: P11.21.B CLINICAL CHARACTERISTICS AND TREATMENT STRATEGIES FOR CANCER CASES PRESENTING WITH CENTRAL NERVOUS SYSTEM SYMPTOMS AS THE INITIAL MANIFESTATION
P11.21.B CLINICAL CHARACTERISTICS AND TREATMENT STRATEGIES FOR CANCER CASES PRESENTING WITH CENTRAL NERVOUS SYSTEM SYMPTOMS AS THE INITIAL MANIFESTATION Open
BACKGROUND Historically, metastatic brain tumors have been associated with a poor prognosis, with median survival reported at approximately six months. Accordingly, brain metastases have often been regarded as a terminal-stage manifestatio…
View article: Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer
Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer Open
The tumor microenvironment (TME) significantly influences cancer prognosis and therapeutic outcomes, yet its composition remains highly heterogeneous, and currently, no highly accessible, high‐throughput method exists to define it. To addr…
View article: Optimization of Scanning Protocol for AI-Integrated Assessment of HER2 Dual Bright-Field In-Situ Hybridization Application in Breast Cancer
Optimization of Scanning Protocol for AI-Integrated Assessment of HER2 Dual Bright-Field In-Situ Hybridization Application in Breast Cancer Open
Accurately determining HER2 status is essential for breast cancer treatment. We developed an AI-integrated in-house application for automated Dual bright-field (BF) in situ hybridization (ISH) analysis on whole slide images (WSIs), althoug…
View article: Clinical and molecular landscape of prolonged SARS-CoV-2 infection with resistance to remdesivir in immunocompromised patients
Clinical and molecular landscape of prolonged SARS-CoV-2 infection with resistance to remdesivir in immunocompromised patients Open
Patients with hematologic diseases have experienced coronavirus disease 2019 (COVID-19) with a prolonged, progressive course. Here, we present clinical, pathological, and virological analyses of three cases of prolonged COVID-19 among pati…
View article: Protein phosphatase 1 regulatory subunit 15 A (PPP1R15A) promoted the progression of gastric cancer by activating cell autophagy under energy stress
Protein phosphatase 1 regulatory subunit 15 A (PPP1R15A) promoted the progression of gastric cancer by activating cell autophagy under energy stress Open
View article: Automated Generation of Lung Cytological Images from Image Findings Using Text-to-Image Technology
Automated Generation of Lung Cytological Images from Image Findings Using Text-to-Image Technology Open
Cytology, a type of pathological examination, involves sampling cells from the human body and observing the morphology of the nucleus, cytoplasm, and cell arrangement. In developing classification AI technologies to support cytology, it is…
View article: Cervical mucus can be used for metabolite screening in cervical cancer
Cervical mucus can be used for metabolite screening in cervical cancer Open
Approximately 660,000 women are diagnosed with cervical cancer annually. Current screening options such as cytology or human papillomavirus testing have limitations, creating a need to identify more effective ancillary biomarkers for triag…
View article: Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer
Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer Open
Immune checkpoint blockade has led to breakthroughs in the treatment of advanced gastric cancer. However, the prominent heterogeneity in gastric cancer, notably the heterogeneity of the tumor microenvironment, highlights the idea that the …
View article: Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade
Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade Open
View article: Performance of an ancillary test for cervical cancer that measures miRNAs and cytokines in serum and cervical mucus
Performance of an ancillary test for cervical cancer that measures miRNAs and cytokines in serum and cervical mucus Open
Currently, human papillomavirus tests and cytology are used to screen for cervical cancer. However, more accurate ancillary screening tests are needed. MicroRNAs (miRNAs) and cytokines are promising biomarkers that are aberrantly expressed…
View article: Automated Report Generation for Lung Cytological Images Using a CNN Vision Classifier and Multiple-Transformer Text Decoders: Preliminary Study
Automated Report Generation for Lung Cytological Images Using a CNN Vision Classifier and Multiple-Transformer Text Decoders: Preliminary Study Open
Cytology plays a crucial role in lung cancer diagnosis. Pulmonary cytology involves cell morphological characterization in the specimen and reporting the corresponding findings, which are extremely burdensome tasks. In this study, we propo…
View article: A Novel Support Vector Machine-Based One-Day, Single-Dose Prediction Model of Genotoxic Hepatocarcinogenicity in Rats
A Novel Support Vector Machine-Based One-Day, Single-Dose Prediction Model of Genotoxic Hepatocarcinogenicity in Rats Open
The development of a rapid and accurate model for determining the genotoxicity and carcinogenicity of chemicals is crucial for effective cancer risk assessment, and it also contributes to cancer prevention. This study aims to develop a one…
View article: DNMTs inhibitor Procyanidin B2 reactivates PTEN’s regulatory effects on abnormal glucose metabolism in gastric cancer
DNMTs inhibitor Procyanidin B2 reactivates PTEN’s regulatory effects on abnormal glucose metabolism in gastric cancer Open
Tumor suppressor PTEN was aberrant silenced in gastric cancer (GC) in our previous study. Activation of PTEN through DNA demethylation is a potential strategy for the treatment of GC. Procyanidin B2 (PB2), an effective DNMT inhibitor, exer…
View article: A prospective clinical trial of diathermy ablation for patients with high-grade cervical intraepithelial neoplasia from a single institution in Japan
A prospective clinical trial of diathermy ablation for patients with high-grade cervical intraepithelial neoplasia from a single institution in Japan Open
View article: Handheld Magnetically Assisted Whole Gastrointestinal Tract Capsule Endoscopy Effectively Detects Oesophagogastrocolorectal Tumours and Polyps: A Randomized Controlled Trial
Handheld Magnetically Assisted Whole Gastrointestinal Tract Capsule Endoscopy Effectively Detects Oesophagogastrocolorectal Tumours and Polyps: A Randomized Controlled Trial Open
View article: Inhibition of cancer cell‑platelet adhesion as a promising therapeutic target for preventing peritoneal dissemination of gastric cancer
Inhibition of cancer cell‑platelet adhesion as a promising therapeutic target for preventing peritoneal dissemination of gastric cancer Open
Platelets form complexes with gastric cancer (GC) cells via direct contact, enhancing their malignant behavior. In the present study, the molecules responsible for GC cell-platelet interactions were examined and their therapeutic applicati…
View article: Utility of cerebrospinal fluid liquid biopsy in distinguishing <scp>CNS</scp> lymphoma from cerebrospinal infectious/demyelinating diseases
Utility of cerebrospinal fluid liquid biopsy in distinguishing <span>CNS</span> lymphoma from cerebrospinal infectious/demyelinating diseases Open
Background Distinguishing between central nervous system lymphoma (CNSL) and CNS infectious and/or demyelinating diseases, although clinically important, is sometimes difficult even using imaging strategies and conventional cerebrospinal f…
View article: Endoscopic features of lymphoid follicles in the colonic mucosa using the image enhanced endoscopy and its association with colorectal adenoma
Endoscopic features of lymphoid follicles in the colonic mucosa using the image enhanced endoscopy and its association with colorectal adenoma Open
Background/Aim Lymphoid follicles hyperplasia (LH) is sometimes observed in the normal colon as small, round, yellowish-white nodules. LH is associated with food hypersensitivity and bowel symptoms and histologically characterized as inten…
View article: A case of chronic gastric anisakiasis coexisting with early gastric cancer.
A case of chronic gastric anisakiasis coexisting with early gastric cancer. Open
Anisakis larvae could have invaded the cancer cells selectively because of the lack of mucin in the cancerous epithelium. Anisakiasis coexisting with cancer is considered reasonable rather than coincidental. In cancer with anisakias…
View article: Examination of postmortem changes in the lungs, trachea, and bronchi in a rat model imaged with small-animal computed tomography.
Examination of postmortem changes in the lungs, trachea, and bronchi in a rat model imaged with small-animal computed tomography. Open
While the air content of the lungs decreased, the volume of the trachea and bronchi temporarily increased after death, indicating the potential to use such measurements to estimate time of death.
View article: Large Inflammatory Myofibroblastic Tumor of the Esophagus: A Case Report and Literature Review
Large Inflammatory Myofibroblastic Tumor of the Esophagus: A Case Report and Literature Review Open
Inflammatory myofibroblastic tumor (IMT) is a rare tumor composed of myofibroblasts with inflammatory blood cell infiltration. It commonly occurs in the lungs and rarely in the esophagus. We herein report a valuable case of IMT originating…
View article: Abstract 4331: Comprehensive analysis of copy number variation and sensitivity to targeted therapy in renal cell carcinoma using in-house cancer gene panel testing
Abstract 4331: Comprehensive analysis of copy number variation and sensitivity to targeted therapy in renal cell carcinoma using in-house cancer gene panel testing Open
Purpose: Immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs) are the main drugs used to treat metastatic renal cell carcinoma (mRCC), but there are no effective biomarkers to determine their use. In this study, we aim…
View article: Data from High Levels of Aberrant DNA Methylation in <i>Helicobacter pylori</i>–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk
Data from High Levels of Aberrant DNA Methylation in <i>Helicobacter pylori</i>–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk Open
Introduction: Risk prediction of gastric cancers is important to implement appropriate screening procedures. Although aberrant DNA methylation is deeply involved in gastric carcinogenesis, its induction by Helicobacter pylori…
View article: Data from High Levels of Aberrant DNA Methylation in <i>Helicobacter pylori</i>–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk
Data from High Levels of Aberrant DNA Methylation in <i>Helicobacter pylori</i>–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk Open
Introduction: Risk prediction of gastric cancers is important to implement appropriate screening procedures. Although aberrant DNA methylation is deeply involved in gastric carcinogenesis, its induction by Helicobacter pylori…
View article: Supplementary Table S1 from High Levels of Aberrant DNA Methylation in <i>Helicobacter pylori</i>–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk
Supplementary Table S1 from High Levels of Aberrant DNA Methylation in <i>Helicobacter pylori</i>–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk Open
Supplementary Table S1 from High Levels of Aberrant DNA Methylation in Helicobacter pylori–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk
View article: Supplementary Table S1 from High Levels of Aberrant DNA Methylation in <i>Helicobacter pylori</i>–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk
Supplementary Table S1 from High Levels of Aberrant DNA Methylation in <i>Helicobacter pylori</i>–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk Open
Supplementary Table S1 from High Levels of Aberrant DNA Methylation in Helicobacter pylori–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk