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View article: Gram-scale preparation of the antibiotic lead compound salicyl-AMS, a potent inhibitor of bacterial salicylate adenylation enzymes
Gram-scale preparation of the antibiotic lead compound salicyl-AMS, a potent inhibitor of bacterial salicylate adenylation enzymes Open
View article: Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in <i>Pseudomonas aeruginosa</i>
Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in <i>Pseudomonas aeruginosa</i> Open
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionDesigned Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosaCheng JiChen…
View article: Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents
Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents Open
There is a paramount need for expanding the drug armamentarium to counter the growing problem of drug-resistant tuberculosis. Salicyl-AMS, an inhibitor of salicylic acid adenylation enzymes, is a first-in-class antibacterial lead compound …
View article: Front Cover: Synthesis of Benzannulated Medium‐ring Lactams via a Tandem Oxidative Dearomatization‐Ring Expansion Reaction (Chem. Eur. J. 50/2018)
Front Cover: Synthesis of Benzannulated Medium‐ring Lactams via a Tandem Oxidative Dearomatization‐Ring Expansion Reaction (Chem. Eur. J. 50/2018) Open
Reversal of electron flow during a tandem oxidative dearomatization–ring-expanding rearomatization reaction was inspired by the East River in New York City, a tidal estuary that reverses direction with each tide. The tandem reaction provid…
View article: Synthesis of Benzannulated Medium‐Ring Lactams via a Tandem Oxidative Dearomatization‐Ring Expansion Reaction
Synthesis of Benzannulated Medium‐Ring Lactams via a Tandem Oxidative Dearomatization‐Ring Expansion Reaction Open
Invited for the cover of this issue is the group of Derek S. Tan at the Memorial Sloan Kettering Cancer Center. The image depicts the East River in New York City, whose current reverses direction in response to tidal events, analogous to r…
View article: Synthesis of Benzannulated Medium‐ring Lactams via a Tandem Oxidative Dearomatization‐Ring Expansion Reaction
Synthesis of Benzannulated Medium‐ring Lactams via a Tandem Oxidative Dearomatization‐Ring Expansion Reaction Open
Medium‐ring natural products exhibit diverse biological activities but such scaffolds are underrepresented in probe and drug discovery efforts due to the limitations of classical macrocyclization reactions. We report herein a tandem oxidat…
View article: CCDC 1534702: Experimental Crystal Structure Determination
CCDC 1534702: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in <i>Pseudomonas aeruginosa</i>
Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in <i>Pseudomonas aeruginosa</i> Open
The Gram-negative bacterial pathogen Pseudomonas aeruginosa uses three interconnected intercellular signaling systems regulated by the transcription factors LasR, RhlR, and MvfR (PqsR), which mediate bacterial cell-cell communication via s…