Tur‐Fu Huang
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View article: Joule‐Heating Synthesis of High‐Entropy Oxide Nanoparticles as Sulfion Oxidation Catalysts for Efficient and Durable Hybrid Seawater Electrolysis
Joule‐Heating Synthesis of High‐Entropy Oxide Nanoparticles as Sulfion Oxidation Catalysts for Efficient and Durable Hybrid Seawater Electrolysis Open
Direct seawater electrolysis for hydrogen production is hindered by high energy consumption and the competing chlorine evolution reaction (CER), which compromises efficiency and generates corrosive byproducts. Replacing oxygen evolution re…
View article: A Novel KGD-Based αIIbβ3 Antagonist Prevents Arterial Thrombosis While Preserving Hemostasis and Avoiding Thrombocytopenia
A Novel KGD-Based αIIbβ3 Antagonist Prevents Arterial Thrombosis While Preserving Hemostasis and Avoiding Thrombocytopenia Open
Current αIIbβ3 antagonists are potent antithrombotic agents, their clinical use is limited by the risk of life-threatening bleeding. Emerging evidence has highlighted key mechanistic differences between thrombosis and hemostasis, opening a…
View article: ALBI Grade Analyses of TACE Combined with Anti-Angiogenesis Therapies Plus PD-1 Inhibitors versus Anti-Angiogenesis Therapies Plus PD-1 Inhibitors in Advanced HCC
ALBI Grade Analyses of TACE Combined with Anti-Angiogenesis Therapies Plus PD-1 Inhibitors versus Anti-Angiogenesis Therapies Plus PD-1 Inhibitors in Advanced HCC Open
TACE+TP had no negative influence on liver function and enhanced survival regardless of baseline ALBI grade when compared to TP in advanced HCC patients.
View article: Templated growth of oriented layered hybrid perovskites on 3D-like perovskites
Templated growth of oriented layered hybrid perovskites on 3D-like perovskites Open
The manipulation of crystal orientation from the thermodynamic equilibrium states is desired in layered hybrid perovskite films to direct charge transport and enhance the perovskite devices performance. Here we report a templated growth me…
View article: #1593 ARGDRR, a novel disintegrin, attenuates AKI to CKD-related renal fibrosis
#1593 ARGDRR, a novel disintegrin, attenuates AKI to CKD-related renal fibrosis Open
Background and Aims Acute kidney injury (AKI) can lead to progress renal fibrosis, resulting in chronic kidney disease (CKD) and end stage renal disease (ESRD). Nevertheless, the underlying pathological mechanisms remain unclear. Platelet …
View article: 4-Acetylantroquinonol B Suppresses Prostate Cancer Growth and Angiogenesis via a VEGF/PI3K/ERK/mTOR-Dependent Signaling Pathway in Subcutaneous Xenograft and In Vivo Angiogenesis Models
4-Acetylantroquinonol B Suppresses Prostate Cancer Growth and Angiogenesis via a VEGF/PI3K/ERK/mTOR-Dependent Signaling Pathway in Subcutaneous Xenograft and In Vivo Angiogenesis Models Open
Prostate cancer is a major cause of cancer-related mortality in men in developed countries. The compound, 4-acetylantroquinonol B (4AAQB), is isolated from Antrodia cinnamomea (commonly known as Niu-Chang-Chih), which has been shown to inh…
View article: Atherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation
Atherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation Open
Cardiovascular disease (CVD) is strongly associated with the gut microbiota and its metabolites, including trimethylamine- N -oxide (TMAO), formed from metaorganismal metabolism of ʟ-carnitine. Raw garlic juice, with allicin as its primary…
View article: Atherosclerosis Amelioration by Allicin in Raw Garlic through Gut Microbiota and Trimethylamine-N-Oxide Modulation
Atherosclerosis Amelioration by Allicin in Raw Garlic through Gut Microbiota and Trimethylamine-N-Oxide Modulation Open
Cardiovascular disease (CVD) is strongly associated with the gut microbiota and its metabolites, including trimethylamine-N-oxide (TMAO) formed from ʟ-carnitine. Raw garlic juice, with allicin as its primary compound, has been shown to pow…
View article: Improved Antithrombotic Activity and Diminished Bleeding Side Effect of a PEGylated αIIbβ3 Antagonist, Disintegrin
Improved Antithrombotic Activity and Diminished Bleeding Side Effect of a PEGylated αIIbβ3 Antagonist, Disintegrin Open
Polymer polyethylene glycol (PEG), or PEGylation of polypeptides improves protein drug stability by decreasing degradation and reducing renal clearance. To produce a pharmaceutical disintegrin derivative, the N-terminal PEGylation techniqu…
View article: A Novel αIIbβ3 Antagonist from Snake Venom Prevents Thrombosis without Causing Bleeding
A Novel αIIbβ3 Antagonist from Snake Venom Prevents Thrombosis without Causing Bleeding Open
Life-threatening thrombocytopenia and bleeding, common side effects of clinically available αIIbβ3 antagonists, are associated with the induction of ligand-induced integrin conformational changes and exposure of ligand-induced binding site…
View article: A novel 2‐aminobenzimidazole‐based compound Jzu 17 exhibits anti‐angiogenesis effects by targeting VEGFR‐2 signalling
A novel 2‐aminobenzimidazole‐based compound Jzu 17 exhibits anti‐angiogenesis effects by targeting VEGFR‐2 signalling Open
Background and Purpose Recent development in drug discovery have shown benzimidazole to be an important pharmacophore,. Benzimidazole derivatives exhibit broad‐spectrum pharmacological properties including anti‐microbial, anti‐diabetic and…
View article: From Discovery of Snake Venom Disintegrins to A Safer Therapeutic Antithrombotic Agent
From Discovery of Snake Venom Disintegrins to A Safer Therapeutic Antithrombotic Agent Open
Snake venoms affect blood coagulation and platelet function in diverse ways. Some venom components inhibit platelet function, while other components induce platelet aggregation. Among the platelet aggregation inhibitors, disintegrins have …
View article: Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 Open
Platelet-leukocyte interactions amplify inflammatory reactions, but the underlying mechanism is still unclear. CLEC5A and CLEC2 are spleen tyrosine kinase (Syk)-coupled C-type lectin receptors, abundantly expressed by leukocytes and platel…
View article: A novel αIIbβ3 antagonist TFV-1 derived from snake venom prevents thrombosis without causing bleeding
A novel αIIbβ3 antagonist TFV-1 derived from snake venom prevents thrombosis without causing bleeding Open
Current alphaIIbbeta3 antagonists are efficacious anti-thrombotics but have significant bleeding risk. The life-threatening thrombocytopenia and bleeding, common side effects of clinically available alphaIIbbeta3 antagonists, are associate…
View article: Novel Benzimidazole Derivatives Effectively Inhibit vascular endothelial growth factor induced angiogenesis and tumor angiogenesis
Novel Benzimidazole Derivatives Effectively Inhibit vascular endothelial growth factor induced angiogenesis and tumor angiogenesis Open
Background: Angiogenesis is the formation of new blood vessels. This process involves the migration, growth, and differentiation of endothelial cells. It plays a critical role in the growth and spread of cancer, due to the new vessels supp…
View article: An αIIbβ3 antagonist prevents thrombosis without causing Fc receptor γ‐chain IIa‐mediated thrombocytopenia
An αIIbβ3 antagonist prevents thrombosis without causing Fc receptor γ‐chain IIa‐mediated thrombocytopenia Open
View article: ARHGEF10 knockout inhibits platelet aggregation and protects mice from thrombus formation
ARHGEF10 knockout inhibits platelet aggregation and protects mice from thrombus formation Open
View article: Trowaglerix Venom Polypeptides As a Novel Antithrombotic Agent by Targeting Immunoglobulin-Like Domains of Glycoprotein VI in Platelet
Trowaglerix Venom Polypeptides As a Novel Antithrombotic Agent by Targeting Immunoglobulin-Like Domains of Glycoprotein VI in Platelet Open
Objective— Currently prescribed antiplatelet drugs have 1 common side effect—an increased risk of hemorrhage and thrombocytopenia. On the contrary, bleeding defects associated with glycoprotein VI (GPVI) expression deficiency are usually s…
View article: Aggretin Venom Polypeptide as a Novel Anti-angiogenesis Agent by Targeting Integrin alpha2beta1
Aggretin Venom Polypeptide as a Novel Anti-angiogenesis Agent by Targeting Integrin alpha2beta1 Open
View article: SOLUTION STRUCTURE OF LYS33 ACETYLATED HUMAN SUMO2
SOLUTION STRUCTURE OF LYS33 ACETYLATED HUMAN SUMO2 Open
View article: SOLUTION STRUCTURE OF LYS42 ACETYLATED HUMAN SUMO2
SOLUTION STRUCTURE OF LYS42 ACETYLATED HUMAN SUMO2 Open
View article: Anti-thrombotic agents derived from snake venom proteins
Anti-thrombotic agents derived from snake venom proteins Open
Snake venoms affect blood coagulation and platelet function in a complex manner. However, two classes of venom proteins, snaclecs and disintegrins have been shown to specifically target receptors including GPIb, α2β1, GPVI, CLEC-2 and inte…
View article: DDA suppresses angiogenesis and tumor growth of colorectal cancer <i>in vivo</i> through decreasing VEGFR2 signaling
DDA suppresses angiogenesis and tumor growth of colorectal cancer <i>in vivo</i> through decreasing VEGFR2 signaling Open
As angiogenesis is required for tumor growth and metastasis, suppressing angiogenesis is a promising strategy in limiting tumor progression. Vascular endothelial growth factor (VEGF)-A, a critical pro-angiogenic factor, has thus become an …
View article: Snake Venom Disintegrin Inhibits the Activation of Toll-Like Receptors and Alleviates Sepsis through Integrin alphaVbeta3 Blockade
Snake Venom Disintegrin Inhibits the Activation of Toll-Like Receptors and Alleviates Sepsis through Integrin alphaVbeta3 Blockade Open
Bacterial infection-induced sepsis is the leading cause of septic inflammatory disease. Rhodostomin (Rn), a snake venom disintegrin, was previously reported to interact with the αVβ3 integrin and the TLR4 on phagocyte in attenuating LPS-in…
View article: Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis
Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis Open
Podoplanin (PDPN) enhances tumor metastases by eliciting tumor cell-induced platelet aggregation (TCIPA) through activation of platelet C-type lectin-like receptor 2 (CLEC-2). A novel and non-cytotoxic 5-nitrobenzoate compound 2CP was synt…