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View article: CCAAT-enhancer binding protein delta functions as a tumor suppressor gene in acute myeloid leukemia
CCAAT-enhancer binding protein delta functions as a tumor suppressor gene in acute myeloid leukemia Open
There is a continued need for identification of novel disease drivers of acute myeloid leukemia as many patients experience relapse and have poor clinical outcomes. Analyses from our study and publicly available datasets predicted CEBPD as…
View article: Comparison of Short Fast Fourier Transform and Continuous Wavelet Transform in Study of Stride Interval
Comparison of Short Fast Fourier Transform and Continuous Wavelet Transform in Study of Stride Interval Open
Neurodegenerative diseases (NDD) are a heterogeneous group of complex diseases characterized by neuronal loss and progressive degeneration of different areas of the nervous system. Gait analysis presents an early recognition system for NDD…
View article: Combinatorial Genomic Biomarkers Associated with High Response in IgE-Dependent Degranulation in Human Mast Cells
Combinatorial Genomic Biomarkers Associated with High Response in IgE-Dependent Degranulation in Human Mast Cells Open
Mast cells are the major effector cells that mediate IgE-dependent allergic reactions. We sought to use integrated network analysis to identify genomic biomarkers associated with high response in IgE-mediated activation of primary human ma…
View article: Combinatorial genomic biomarkers associated with high response in IgE-dependent human mast cell degranulation
Combinatorial genomic biomarkers associated with high response in IgE-dependent human mast cell degranulation Open
Background: Mast cells are the major effector cells that mediate IgE-dependent allergic reactions via high-affinity IgE receptors. We sought to use integrated network analysis to identify genomic biomarkers associated with high response in…
View article: (379) The Effect of 5-α Reductase Inhibitor on Male Reproductive Function
(379) The Effect of 5-α Reductase Inhibitor on Male Reproductive Function Open
Introduction 5α-reductase inhibitor (5-ARI) such as finasteride or dutasteride has been approved to treat benign prostatic hyperplasia and androgenic alopecia (male pattern hair loss), which blocks the conversion of testosterone to dihydro…
View article: IgE reactivity patterns in Asian and central European cockroach-sensitized patients reveal differences in primary sensitizing allergen sources
IgE reactivity patterns in Asian and central European cockroach-sensitized patients reveal differences in primary sensitizing allergen sources Open
Molecular profiling identified differences between CR-sensitized allergic patients from HK and Austria in terms of primary sensitizers and molecular IgE reactivity patterns. Tropomyosin from American cockroach (Per a 7) was shown to be sig…
View article: Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era?
Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era? Open
In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on the likely benefits of topical therapy of asthma with …
View article: Updated consensus statements on COVID-19 Vaccine Allergy Safety in Hong Kong
Updated consensus statements on COVID-19 Vaccine Allergy Safety in Hong Kong Open
Due to global concerns over coronavirus disease 2019 (COVID-19) vaccine-associated allergic reactions; the Hong Kong Institute of Allergy (HKIA) formulated an initial set of consensus statements (CS) on COVID-19 Vaccine Allergy Safety (VAS…
View article: Consensus Statements on the Approach to COVID-19 Vaccine Allergy Safety in Hong Kong
Consensus Statements on the Approach to COVID-19 Vaccine Allergy Safety in Hong Kong Open
Background: Mass coronavirus disease 2019 (COVID-19) vaccination to achieve herd immunity is an effective means to mitigate the current COVID-19 pandemic. Reports of COVID-19 vaccine-associated allergic reactions and lack of clear local gu…
View article: Review of monoclonal antibody therapies in asthma and allergic diseases - a new paradigm for precision medicine
Review of monoclonal antibody therapies in asthma and allergic diseases - a new paradigm for precision medicine Open
Launch of these new biologicals may revolutionise the treatment of allergic diseases if employed in an endotype-specific fashion, heralding an unprecedented era of personalised medicine.
View article: Peanut allergy and oral immunotherapy
Peanut allergy and oral immunotherapy Open
Peanut allergy is the commonest cause of food-induced anaphylaxis in the world, and it can be fatal. There have been many recent improvements to achieve safe methods of peanut desensitisation, one of which is to use a combination of anti-i…
View article: Hong Kong Institute of Allergy and Hong Kong Society for Paediatric Immunology Allergy & Infectious Diseases joint consensus statement 2018 on vaccination in egg-allergic patients
Hong Kong Institute of Allergy and Hong Kong Society for Paediatric Immunology Allergy & Infectious Diseases joint consensus statement 2018 on vaccination in egg-allergic patients Open
Vaccination of egg-allergic individuals has been a historical concern, particularly for influenza and measles-mumps-rubella-varicella vaccines that are developed in chicken egg embryos or chicken cell fibroblasts. The egg proteins in these…
View article: Profiling of healthy and asthmatic airway smooth muscle cells following interleukin-1β treatment: a novel role for CCL20 in chronic mucus hypersecretion
Profiling of healthy and asthmatic airway smooth muscle cells following interleukin-1β treatment: a novel role for CCL20 in chronic mucus hypersecretion Open
Chronic mucus hypersecretion (CMH) contributes to the morbidity and mortality of asthma, and remains uncontrolled by current therapies in the subset of patients with severe, steroid-resistant disease. Altered cross-talk between airway epit…
View article: The effects of global warming on allergic diseases
The effects of global warming on allergic diseases Open
Global warming is a public health emergency. Substantial scientific evidence indicates an unequivocal rising trend in global surface temperature that has caused higher atmospheric levels of moisture retention leading to more frequent extre…
View article: Genetically modified foods and allergy
Genetically modified foods and allergy Open
2015 marked the 25th anniversary of the commercial use and availability of genetically modified crops. The area of planted biotech crops cultivated globally occupies a cumulative two billion hectares, equivalent to twice the land size of C…
View article: Guidelines for allergy prevention in Hong Kong
Guidelines for allergy prevention in Hong Kong Open
Allergic diseases are a global problem.Mothers are advised to enjoy a healthy diet with no restrictions during pregnancy and lactation, as prophylactic dietary restriction is unlikely to reduce the development of atopic disease.Breastfeedi…
View article: Effects of Air Pollution and the Introduction of the London Low Emission Zone on the Prevalence of Respiratory and Allergic Symptoms in Schoolchildren in East London: A Sequential Cross-Sectional Study
Effects of Air Pollution and the Introduction of the London Low Emission Zone on the Prevalence of Respiratory and Allergic Symptoms in Schoolchildren in East London: A Sequential Cross-Sectional Study Open
The adverse effects of traffic-related air pollution on children's respiratory health have been widely reported, but few studies have evaluated the impact of traffic-control policies designed to reduce urban air pollution. We assessed asso…
View article: Urban Particulate Matter–Activated Human Dendritic Cells Induce the Expansion of Potent Inflammatory Th1, Th2, and Th17 Effector Cells
Urban Particulate Matter–Activated Human Dendritic Cells Induce the Expansion of Potent Inflammatory Th1, Th2, and Th17 Effector Cells Open
Exposure to urban particulate matter (UPM) exacerbates asthmatic lung inflammation. Lung dendritic cells (DCs) are critical for stimulating T cell immunity and in maintaining airway tolerance, but they also react to airway UPM. The adjuvan…
View article: Allergy in Hong Kong: an unmet need in service provision and training
Allergy in Hong Kong: an unmet need in service provision and training Open
Many children in Hong Kong have allergic diseases and epidemiological data support a rising trend. Only a minority of children will grow out of their allergic diseases, so the heavy clinical burden will persist into adulthood. In an otherw…