Thanh Hoa Vo
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View article: A PD-1/PD-L1-Sensitive Co-culture-Based Primary T-Cell Activation Assay
A PD-1/PD-L1-Sensitive Co-culture-Based Primary T-Cell Activation Assay Open
Programmed cell death protein 1 (PD-1) is crucial in inhibiting immune responses by modulating the activity of T cells. We present an in vitro assay that is based on a co-culture of primary immune cells represented by human peripheral bloo…
View article: In Vitro Model for Studying Interaction of Immune Cells and Cancer Cells
In Vitro Model for Studying Interaction of Immune Cells and Cancer Cells Open
The tumor microenvironment (TME) is a complex environment composed of a variety of cell types including cancer cells, endothelial cells, and immune cells. Cross talk between the cells in TME plays a central role in tumor growth, progressio…
View article: Artificial Intelligence and the Evolving Landscape of Immunopeptidomics
Artificial Intelligence and the Evolving Landscape of Immunopeptidomics Open
Background Immunopeptidomics is the large‐scale study of peptides presented by major histocompatibility complex (MHC) molecules and plays a central role in neoantigen discovery and cancer immunotherapy. However, the complexity of mass spec…
View article: Mechanism of miRNAs and miRNA-mRNA Regulatory Networks in Modulating Drug Resistance in HER2-Positive Breast Cancer: An Integrative Bioinformatics Approach
Mechanism of miRNAs and miRNA-mRNA Regulatory Networks in Modulating Drug Resistance in HER2-Positive Breast Cancer: An Integrative Bioinformatics Approach Open
Background: HER2-positive breast cancer is an aggressive subtype where innate/acquired resistance to targeted drugs remains a challenge. This study aims to uncover the underlying mechanisms of HER2 drug resistance through miRNA analysis an…
View article: Analysis of miRNAs: Biomarkers for HER2-Targeted Breast Cancer Therapy
Analysis of miRNAs: Biomarkers for HER2-Targeted Breast Cancer Therapy Open
Breast cancer remains a leading lethal cancer in women globally, with the HER2+ positive subtype associated with a higher chance of therapeutic resistance. Treatments tailored specifically to this subtype, such as targeted therapies, have …
View article: miRNAs as biomarkers of therapeutic response to HER2-targeted treatment in breast cancer: A systematic review
miRNAs as biomarkers of therapeutic response to HER2-targeted treatment in breast cancer: A systematic review Open
Breast cancer is the most common type of lethal cancer in women globally. Women have a 1 in 8 chance of developing breast cancer in their lifetime. Among the four primary molecular subtypes (luminal A, luminal B, HER2+, and triple-negative…
View article: Artificial intelligent-based personalized predictive ischemic stroke among type 2 diabetes mellitus complication patients
Artificial intelligent-based personalized predictive ischemic stroke among type 2 diabetes mellitus complication patients Open
Objectives The objective of this study was to apply machine learning algorithms to predict the risk of ischemic stroke in type 2 diabetes mellitus patients who were prescribed antidiabetic medications. This is an important complication of …
View article: Omics-based deep learning approaches for lung cancer decision-making and therapeutics development
Omics-based deep learning approaches for lung cancer decision-making and therapeutics development Open
Lung cancer has been the most common and the leading cause of cancer deaths globally. Besides clinicopathological observations and traditional molecular tests, the advent of robust and scalable techniques for nucleic acid analysis has revo…
View article: The Distribution of Autoantibodies by Age Group in Children with Type 1 Diabetes versus Type 2 Diabetes in Southern Vietnam
The Distribution of Autoantibodies by Age Group in Children with Type 1 Diabetes versus Type 2 Diabetes in Southern Vietnam Open
Asian children are increasingly being diagnosed with type 1 diabetes (T1D) or type 2 diabetes (T2D), and the presence of coexisting islet autoimmune antibodies complicate diagnosis. Here, we aimed to determine the prevalence of islet cell …
View article: ALDH2 as a potential stem cell-related biomarker in lung adenocarcinoma: Comprehensive multi-omics analysis
ALDH2 as a potential stem cell-related biomarker in lung adenocarcinoma: Comprehensive multi-omics analysis Open
Lung adenocarcinoma (LUAD) is the most prevalent lung cancer and one of the leading causes of death. Previous research found a link between LUAD and Aldehyde Dehydrogenase 2 (ALDH2), a member of aldehyde dehydrogenase gene (ALDH) superfami…
View article: 341 Ovarian cancer care at a hospital with an igcs global curriculum fellowship
341 Ovarian cancer care at a hospital with an igcs global curriculum fellowship Open
Objectives To determine the impact of implementation of an IGCS global curriculum fellowship on cancer care. Methods We performed a retrospective review of consecutive ovarian cancer cases treated since the start of the IGCS Global Curricu…