Thadryan Sweeney
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View article: Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment
Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment Open
Background The last few years have seen major advances in blood biomarkers for Alzheimer's Disease (AD) with the development of ultrasensitive immunoassays, promising to transform how we diagnose, prognose, and track progression of neurode…
View article: Distinct Stress‐Dependent Signatures of Cellular and Extracellular tRNA‐Derived Small RNAs (Adv. Sci. 17/2022)
Distinct Stress‐Dependent Signatures of Cellular and Extracellular tRNA‐Derived Small RNAs (Adv. Sci. 17/2022) Open
Extracellular tRNA‐Derived Small RNAs In article number 2200829, Saumya Das and co‐workers provide a comprehensive landscape for the signature of cellular and extracellular tRNA‐derived small RNAs (tDRs) in response to different stressors.…
View article: Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer’s disease
Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer’s disease Open
Background There is currently a lack of reliable and easily accessible biomarkers predicting cognitive decline in Alzheimer’s disease (AD). Synaptic dysfunction and loss occur early in AD and synaptic loss measured in the brain tissue and …
View article: Plasma biomarkers for diagnosis of Alzheimer’s disease and prediction of cognitive decline in individuals with mild cognitive impairment
Plasma biomarkers for diagnosis of Alzheimer’s disease and prediction of cognitive decline in individuals with mild cognitive impairment Open
Background The last few years have seen major advances in blood biomarkers for Alzheimer’s Disease (AD) with the development of ultrasensitive immunoassays, promising to transform how we diagnose, prognose, and track progression of neurode…
View article: Distinct Stress‐Dependent Signatures of Cellular and Extracellular tRNA‐Derived Small RNAs
Distinct Stress‐Dependent Signatures of Cellular and Extracellular tRNA‐Derived Small RNAs Open
The cellular response to stress is an important determinant of disease pathogenesis. Uncovering the molecular fingerprints of distinct stress responses may identify novel biomarkers and key signaling pathways for different diseases. Emergi…
View article: A Novel Tissue Atlas and Online Tool for the Interrogation of Small RNA Expression in Human Tissues and Biofluids
A Novel Tissue Atlas and Online Tool for the Interrogation of Small RNA Expression in Human Tissues and Biofluids Open
One promising goal for utilizing the molecular information circulating in biofluids is the discovery of clinically useful biomarkers. Extracellular RNAs (exRNAs) are one of the most diverse classes of molecular cargo, easily assayed by seq…
View article: Increased levels of the synaptic proteins PSD-95, SNAP-25, and Neurogranin in the cerebrospinal fluid of patients with Alzheimer’s Disease
Increased levels of the synaptic proteins PSD-95, SNAP-25, and Neurogranin in the cerebrospinal fluid of patients with Alzheimer’s Disease Open
Background: There is currently a lack of reliable and easily accessible biomarkers predicting cognitive decline in Alzheimer’s Disease (AD). Synaptic dysfunction and loss occur early in AD and synaptic loss measured in brain tissue and by …
View article: Additional file 4 of Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer’s disease
Additional file 4 of Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer’s disease Open
Additional file 4: Supplementary Table 2. CSF levels of synaptic markers in diagnostic groups.
View article: Additional file 3 of Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer’s disease
Additional file 3 of Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer’s disease Open
Additional file 3: Supplementary Table 1. Correlations between CSF levels of synaptic markers in different groups.
View article: Distinct stress-dependent signatures of cellular and extracellular tRNA-derived small RNAs (tDRs)
Distinct stress-dependent signatures of cellular and extracellular tRNA-derived small RNAs (tDRs) Open
SUMMARY The cellular response to stress is an important determinant of disease pathogenesis. Uncovering the molecular fingerprints of distinct stress responses may yield novel biomarkers for different diseases, and potentially identify key…
View article: Evaluation of serological lateral flow assays for severe acute respiratory syndrome coronavirus-2
Evaluation of serological lateral flow assays for severe acute respiratory syndrome coronavirus-2 Open
Background: COVID-19 has resulted in significant morbidity and mortality worldwide. Lateral flow assays can detect anti-Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) antibodies to monitor transmission. However, standardized …
View article: Evaluation of serological lateral flow assays for severe acute respiratory syndrome coronavirus-2
Evaluation of serological lateral flow assays for severe acute respiratory syndrome coronavirus-2 Open
Background COVID-19 has resulted in significant morbidity and mortality worldwide. Lateral flow assays can detect anti-Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) antibodies to monitor transmission. However, standardized e…