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View article: A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss Open
The emergence of glucagon-like peptide-1 agonists represents a notable advancement in the pharmacological treatment of obesity, yet complementary approaches are essential. Through phenotypic drug discovery, we developed promising nitroalke…
View article: Ecto-CD38-NADase inhibition modulates cardiac metabolism and protects mice against doxorubicin-induced cardiotoxicity
Ecto-CD38-NADase inhibition modulates cardiac metabolism and protects mice against doxorubicin-induced cardiotoxicity Open
Aims Doxorubicin (DXR) is a chemotherapeutic agent that causes dose-dependent cardiotoxicity. Recently, it has been proposed that the NADase CD38 may play a role in doxorubicin-induced cardiotoxicity (DIC). CD38 is the main NAD+-catabolizi…
View article: Heavy-chain antibody targeting of CD38 NAD+ hydrolase ectoenzyme to prevent fibrosis in multiple organs
Heavy-chain antibody targeting of CD38 NAD+ hydrolase ectoenzyme to prevent fibrosis in multiple organs Open
The functionally pleiotropic ectoenzyme CD38 is a glycohydrolase widely expressed on immune and non-hematopoietic cells. By converting NAD + to ADP-ribose and nicotinamide, CD38 governs organismal NAD + homeostasis and the activity of NAD …
View article: A nitroalkene derivative of salicylate alleviates diet-induced obesity by activating creatine metabolism and non-shivering thermogenesis
A nitroalkene derivative of salicylate alleviates diet-induced obesity by activating creatine metabolism and non-shivering thermogenesis Open
View article: Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide)
Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide) Open
View article: CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging
CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging Open
Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction. The NADase CD38 plays a key role in age‐related NAD decline. Whether the inhibition of CD38 increases lifespan is not …
View article: Dihydronicotinamide Riboside Is a Potent NAD+ Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages
Dihydronicotinamide Riboside Is a Potent NAD+ Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages Open
Nicotinamide adenine dinucleotide (NAD) metabolism plays an important role in the regulation of immune function. However, a complete picture of how NAD, its metabolites, precursors, and metabolizing enzymes work together in regulating immu…
View article: The CD38 glycohydrolase and the NAD sink: implications for pathological conditions
The CD38 glycohydrolase and the NAD sink: implications for pathological conditions Open
Nicotinamide adenine dinucleotide (NAD) acts as a cofactor in several oxidation-reduction (redox) reactions and is a substrate for a number of nonredox enzymes. NAD is fundamental to a variety of cellular processes including energy metabol…
View article: Benefits in cardiac function by CD38 suppression: Improvement in NAD+ levels, exercise capacity, heart rate variability and protection against catecholamine-induced ventricular arrhythmias
Benefits in cardiac function by CD38 suppression: Improvement in NAD+ levels, exercise capacity, heart rate variability and protection against catecholamine-induced ventricular arrhythmias Open
View article: Endogenous Metabolism in Endothelial and Immune Cells Is the Main Source of Tissue Levels of the Vitamin B <sub>3</sub> Nicotinamide
Endogenous Metabolism in Endothelial and Immune Cells Is the Main Source of Tissue Levels of the Vitamin B <sub>3</sub> Nicotinamide Open
View article: A Nitroalkene Derivative of Salicylate Alleviates Diet-Induced Obesity by Activation of Creatine-Dependent Thermogenesis
A Nitroalkene Derivative of Salicylate Alleviates Diet-Induced Obesity by Activation of Creatine-Dependent Thermogenesis Open
View article: Critical Role of Astrocyte NAD <sup>+</sup> Glycohydrolase in Myelin Injury and Regeneration
Critical Role of Astrocyte NAD <sup>+</sup> Glycohydrolase in Myelin Injury and Regeneration Open
Western-style diets cause disruptions in myelinating cells and astrocytes within the mouse CNS. Increased CD38 expression is present in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination and CD38 is the mai…
View article: FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue
FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue Open
View article: FBF1 Deficiency Promotes Beiging and Healthy Expansion of White Adipose Tissue
FBF1 Deficiency Promotes Beiging and Healthy Expansion of White Adipose Tissue Open
View article: CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels Open
View article: The NADase enzyme CD38: an emerging pharmacological target for systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis
The NADase enzyme CD38: an emerging pharmacological target for systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis Open
Purpose of review Here we review recent literature on the emerging role of nicotinamide adenine dinucleotide (NAD + ) metabolism and its dysfunction via the enzyme CD38 in the pathogenesis of rheumatologic diseases. We evaluate the potenti…
View article: Critical role for astrocyte NAD<sup>+</sup>glycohydrolase in myelin injury and regeneration
Critical role for astrocyte NAD<sup>+</sup>glycohydrolase in myelin injury and regeneration Open
Western-style diets cause disruptions in myelinating cells and astrocytes within the mouse CNS. CD38 has increased expression in the cuprizone and EAE demyelination models and is the main NAD + depleting enzyme in CNS tissue. Altered NAD +…
View article: The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline Open
Tissue nicotinamide adenine dinucleotide (NAD+) decline has been implicated in aging. We have recently identified CD38 as a central regulator involved in tissue NAD+ decline during the aging process. CD38 is an ecto-e…
View article: The Prognostic Value and Clinical Use of Myocardial Perfusion Scintigraphy in Asymptomatic Patients after Percutaneous Coronary Intervention
The Prognostic Value and Clinical Use of Myocardial Perfusion Scintigraphy in Asymptomatic Patients after Percutaneous Coronary Intervention Open
Although this information is not contemplated in guidelines, in this study MPS was able to predict events in asymptomatic after PCI patients, regardless of when they were performed.
View article: The Prognostic Value and Clinical Use of Myocardial Perfusion Scintigraphy in Asymptomatic Patients after Percutaneous Coronary Intervention
The Prognostic Value and Clinical Use of Myocardial Perfusion Scintigraphy in Asymptomatic Patients after Percutaneous Coronary Intervention Open
Background: The role of myocardial perfusion scintigraphy (MPS) in the follow-up of asymptomatic patients after percutaneous coronary intervention (PCI) is not established. Objectives: To evaluate the prognostic value and clinical use of M…
View article: P5317Metabolically healthy obesity: clinical features and all-cause mortality
P5317Metabolically healthy obesity: clinical features and all-cause mortality Open
View article: Preliminary Data on the Prognostic Value of a New Protocol of Ultra-fast Myocardial Scintigraphy with Less Radiation in CZT Gamma Camera
Preliminary Data on the Prognostic Value of a New Protocol of Ultra-fast Myocardial Scintigraphy with Less Radiation in CZT Gamma Camera Open
Fundamentos: A cintilografia miocárdica de perfusão (CMP) é um dos métodos mais utilizados na avaliação de pacientes com suspeita de coronariopatia por seu valor diagnóstico e prognóstico.Duas de suas maiores limitações são o uso de radiaç…