Thomas G. Bifano
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View article: Superresolution imaging of live samples by centroid reassignment microscopy
Superresolution imaging of live samples by centroid reassignment microscopy Open
Superresolution imaging has become one of the most important recent advances in microscopy development. However, most superresolution methods are ill-adapted for live-sample imaging because they are unacceptably slow, susceptible to artifa…
View article: Electromagnetic deformable mirror fabricated using silicon micromachining and stress-resilient assembly
Electromagnetic deformable mirror fabricated using silicon micromachining and stress-resilient assembly Open
Introduction: This work presents a prototype electromagnetic actuation deformable mirror (DM) assembly with stress-resilient face sheet design. Methods: The DM face sheet design includes slender micromachined silicon pillars that are integ…
View article: Computational‐Design Enabled Wearable and Tunable Metamaterials via Freeform Auxetics for Magnetic Resonance Imaging (Adv. Sci. 26/2024)
Computational‐Design Enabled Wearable and Tunable Metamaterials via Freeform Auxetics for Magnetic Resonance Imaging (Adv. Sci. 26/2024) Open
Computational‐Design In 2400261 by Stephan W. Anderson, Xin Zhang, and co‐workers, a computational method is reported to design wearable and tunable metamaterials via freeform auxetics for magnetic resonance imaging. The computational desi…
View article: Computational‐Design Enabled Wearable and Tunable Metamaterials via Freeform Auxetics for Magnetic Resonance Imaging
Computational‐Design Enabled Wearable and Tunable Metamaterials via Freeform Auxetics for Magnetic Resonance Imaging Open
Metamaterials hold significant promise for enhancing the imaging capabilities of magnetic resonance imaging (MRI) machines as an additive technology, due to their unique ability to enhance local magnetic fields. However, despite their pote…
View article: Computational-design Enabled Wearable and Tunable Metamaterials via Freeform Auxetics for Magnetic Resonance Imaging
Computational-design Enabled Wearable and Tunable Metamaterials via Freeform Auxetics for Magnetic Resonance Imaging Open
Metamaterials hold significant promise for enhancing the imaging capabilities of MRI machines as an additive technology, due to their unique ability to enhance local magnetic fields. However, despite their potential, the metamaterials repo…
View article: High throughput screening system for engineered cardiac tissues
High throughput screening system for engineered cardiac tissues Open
Introduction: Three dimensional engineered cardiac tissues (3D ECTs) have become indispensable as in vitro models to assess drug cardiotoxicity, a leading cause of failure in pharmaceutical development. A current bottleneck is the relative…
View article: A Design Approach to Reducing Stress and Distortion Caused by Adhesive Assembly in Micromachined Deformable Mirrors
A Design Approach to Reducing Stress and Distortion Caused by Adhesive Assembly in Micromachined Deformable Mirrors Open
A common problem in deformable mirror assembly is that the adhesion of actuators to an optical mirror face sheet introduces unwanted topography due to large local stresses generated at the adhesive joint. A new approach to minimizing that …
View article: Dynamic Control of Contractile Force in Engineered Heart Tissue
Dynamic Control of Contractile Force in Engineered Heart Tissue Open
The capacity to alter the mechanical boundary conditions of an engineered tissue dynamically offers a new way to probe tissue mechanics. This could be used to mimic afterload changes that occur naturally in disease, or to improve mechanica…
View article: Three-Photon Adaptive Optics for Mouse Brain Imaging
Three-Photon Adaptive Optics for Mouse Brain Imaging Open
Three-photon microscopy (3PM) was shown to allow deeper imaging than two-photon microscopy (2PM) in scattering biological tissues, such as the mouse brain, since the longer excitation wavelength reduces tissue scattering and the higher-ord…
View article: Auxetics‐Inspired Tunable Metamaterials for Magnetic Resonance Imaging (Adv. Mater. 6/2022)
Auxetics‐Inspired Tunable Metamaterials for Magnetic Resonance Imaging (Adv. Mater. 6/2022) Open
Tunable Metamaterials In article number 2109032, Stephan W. Anderson, Xin Zhang, and co-workers exploit auxetic structures with a negative Poisson's ratio, exhibiting counterintuitive behaviors, to design mechanically tunable metamaterials…
View article: Dual-update data-driven control of deformable mirrors using Walsh basis functions
Dual-update data-driven control of deformable mirrors using Walsh basis functions Open
We develop a novel data-driven method for deformable mirror (DM) control. The developed method updates both the DM model and DM control actions that produce desired mirror surface shapes. The novel method explicitly takes into account actu…
View article: Auxetics‐Inspired Tunable Metamaterials for Magnetic Resonance Imaging
Auxetics‐Inspired Tunable Metamaterials for Magnetic Resonance Imaging Open
Auxetics refers to structures or materials with a negative Poisson's ratio, thereby capable of exhibiting counterintuitive behaviors. Herein, auxetic structures are exploited to design mechanically tunable metamaterials in both planar and …
View article: Dynamic Control of Contractile Force in Engineered Heart Tissue
Dynamic Control of Contractile Force in Engineered Heart Tissue Open
Three-dimensional engineered heart tissues (EHTs) derived from human induced pluripotent stem cells (iPSCs) have become an important resource for both drug toxicity screening and research on heart disease. A key metric of EHT phenotype is …
View article: Dynamic Control of Contractile Force in Engineered Heart Tissue
Dynamic Control of Contractile Force in Engineered Heart Tissue Open
Three-dimensional engineered heart tissues (EHTs) derived from human induced pluripotent stem cells (iPSCs) have become an important resource for both drug toxicity screening and research on heart disease. A key metric of EHT phenotype is …
View article: An adaptive optics module for deep tissue multiphoton imaging in vivo
An adaptive optics module for deep tissue multiphoton imaging in vivo Open
Understanding complex biological systems requires visualizing structures and processes deep within living organisms. We developed a compact adaptive optics module and incorporated it into two- and three-photon fluorescence microscopes, to …
View article: An adaptive optics module for deep tissue multiphoton imaging <i>in vivo</i>
An adaptive optics module for deep tissue multiphoton imaging <i>in vivo</i> Open
Understanding complex biological systems requires visualizing structures and processes deep within living organisms. We developed a compact adaptive optics module and incorporated it into two- and three-photon fluorescence microscopes, to …
View article: Nonreciprocity: Nonreciprocal Magnetic Coupling Using Nonlinear Meta‐Atoms (Adv. Sci. 19/2020)
Nonreciprocity: Nonreciprocal Magnetic Coupling Using Nonlinear Meta‐Atoms (Adv. Sci. 19/2020) Open
In article number 2001443, Stephan W. Anderson, Xin Zhang, and co‐workers demonstrate a nonreciprocal system based on the linear and nonlinear meta‐atoms. Theoretical studies and experiments reveal the bounds of the nonreciprocity based on…
View article: Volumetric chemical imaging in vivo by a remote-focusing stimulated Raman scattering microscope
Volumetric chemical imaging in vivo by a remote-focusing stimulated Raman scattering microscope Open
Operable under ambient light and providing chemical selectivity, stimulated Raman scattering (SRS) microscopy opens a new window for imaging molecular events on a human subject, such as filtration of topical drugs through the skin. A typic…
View article: Polarization insensitive, metamaterial absorber-enhanced long-wave infrared detector
Polarization insensitive, metamaterial absorber-enhanced long-wave infrared detector Open
Detecting low energy photons, such as photons in the long-wave infrared range, is a technically challenging proposition using naturally occurring materials. In order to address this challenge, we herein demonstrate a micro-bolometer featur…
View article: Nonreciprocal Magnetic Coupling Using Nonlinear Meta‐Atoms
Nonreciprocal Magnetic Coupling Using Nonlinear Meta‐Atoms Open
Breaking Lorentz reciprocity is fundamental to an array of functional radiofrequency (RF) and optical devices, such as isolators and circulators. The application of external excitation, such as magnetic fields and spatial–temporal modulati…
View article: PWM as a Low Cost Method for the Analog Control of MEMS Devices
PWM as a Low Cost Method for the Analog Control of MEMS Devices Open
In this paper, we discuss the use of pulse width modulation (PWM) to control analog MEMS devices. We achieve a precise linear analog control of MEMS by applying PWM signal with a frequency well above the system's mechanical natural frequen…
View article: Simultaneous multiplane imaging with reverberation multiphoton microscopy
Simultaneous multiplane imaging with reverberation multiphoton microscopy Open
Multiphoton microscopy (MPM) has gained enormous popularity over the years for its capacity to provide high resolution images from deep within scattering samples1. However, MPM is generally based on single-point laser-focus scanning, which…
View article: High-throughput label-free flow cytometry based on matched-filter compressive imaging
High-throughput label-free flow cytometry based on matched-filter compressive imaging Open
We present a fast label-free computational flow cytometer based on a strategy of compressive imaging. Scattered light from flowing objects is sub-divided into user-defined basis patterns by a deformable mirror and routed to different detec…
View article: PWM as a Low Cost Method for the Analog Control of MEMS Devices
PWM as a Low Cost Method for the Analog Control of MEMS Devices Open
In this paper we discuss the use of pulse width modulation (PWM) to control analog MEMS devices. We achieve precise linear analog control of MEMS by applying a PWM signal with a frequency well above the system's mechanical natural frequenc…
View article: Axial localization with modulated-illumination extended-depth-of-field microscopy
Axial localization with modulated-illumination extended-depth-of-field microscopy Open
High-speed volumetric imaging represents a challenge in microscopy applications. We demonstrate a technique for acquiring volumetric images based on the extended depth of field microscopy with a fast focal scan and modulated illumination. …
View article: Special Section Guest Editorial: Adaptive Optics and Wavefront Control for Biological Systems
Special Section Guest Editorial: Adaptive Optics and Wavefront Control for Biological Systems Open
The Journal of Biomedical Optics (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use of novel optical systems and techniques for improved health care and biomedical research.