Tricia Naicker
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View article: Base-Mediated Tandem Michael Addition and SuFEx Cyclization for the Synthesis of Sultone-Containing Spirooxindoles
Base-Mediated Tandem Michael Addition and SuFEx Cyclization for the Synthesis of Sultone-Containing Spirooxindoles Open
Sulfur-containing spirooxindoles are recognized for their significant biological activity, yet accessing these compounds with diverse heteroatoms in the spirocyclic core has remained challenging. This study introduces a simple and efficien…
View article: Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents
Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents Open
An efficient microwave‐assisted synthesis route for novel oxazolidinone analogues has been developed. The general synthesis of these compounds began with an L‐proline‐mediated three‐component Mannich reaction between commercially available…
View article: Gallium-68-NODASA-Functionalized D-Lysine Radiosynthesis and first-line in vitro characterization - a potential PET imaging agent for infection
Gallium-68-NODASA-Functionalized D-Lysine Radiosynthesis and first-line in vitro characterization - a potential PET imaging agent for infection Open
The advancement of new Positron Emission Tomography (PET) radiotracers for differentiating bacterial infections from sterile inflammation is essential for accurate diagnosis and treatment monitoring. D-amino acid-based probes have shown pr…
View article: Navigating the complexities of drug development for metallo-β-lactamase inhibitors
Navigating the complexities of drug development for metallo-β-lactamase inhibitors Open
Standardized approaches to MBL inhibitor development are vital. This work highlights the benefits of uniform methodologies while addressing key preclinical challenges to bridge the gap toward successful clinical translation.
View article: Development and <i>in vitro</i> evaluation of 1,4,7-triazacyclononane-coupled β-lactams against metallo-β-lactamase producing bacteria
Development and <i>in vitro</i> evaluation of 1,4,7-triazacyclononane-coupled β-lactams against metallo-β-lactamase producing bacteria Open
Eight new MBL inhibitors, designed using a 1,4,7-triazacyclononane (NO3PY) chelator linked to a β-lactam, restored the efficacy of meropenem, reducing its minimum inhibitory concentration against MBL-expressing pathogens.
View article: Immunoexpression of placental growth factor (PlGF) and soluble FMS-like tyrosine kinase 1 (sFlt-1) in the placental bed of preeclamptic women of African ancestry living with HIV infection
Immunoexpression of placental growth factor (PlGF) and soluble FMS-like tyrosine kinase 1 (sFlt-1) in the placental bed of preeclamptic women of African ancestry living with HIV infection Open
Preeclampsia, a severe pregnancy complication linked to defective placentation, poses significant maternal risks and is characterized by dysregulated angiogenic factors, including placental growth factor (PlGF) and soluble fms-like tyrosin…
View article: The Oxidation of Electron-Rich Arenes Using a H<sub>2</sub>O<sub>2</sub>–Proline System
The Oxidation of Electron-Rich Arenes Using a H<sub>2</sub>O<sub>2</sub>–Proline System Open
This study introduces a novel proline-catalyzed oxidation system employing hydrogen peroxide to synthesize quinones from a diverse range of substrates, including hydroquinones, phenols, resorcinols, aldehydes, and polycyclic aromatics. Thi…
View article: <sup>68</sup>Ga Radiolabeling of NODASA‐Functionalized Phage Display–Derived Peptides for Prospective Assessment as Tuberculosis‐Specific PET Radiotracers
<sup>68</sup>Ga Radiolabeling of NODASA‐Functionalized Phage Display–Derived Peptides for Prospective Assessment as Tuberculosis‐Specific PET Radiotracers Open
This research presents the development of positron emission tomography (PET) radiotracers for detecting Mycobacterium tuberculosis (MTB) for the diagnosis and monitoring of tuberculosis. Two phage display–derived peptides with proven selec…
View article: Immunoexpression of Placental Growth Factor (PlGF) and Soluble FMS-like Tyrosine Kinase 1 (sFlt-1) in the Placental Bed of Preeclamptic women of African ancestry living with HIV infection
Immunoexpression of Placental Growth Factor (PlGF) and Soluble FMS-like Tyrosine Kinase 1 (sFlt-1) in the Placental Bed of Preeclamptic women of African ancestry living with HIV infection Open
Background: Preeclampsia, a serious pregnancy complication, is associated with defective placentation and adverse maternal risk. Placental Growth Factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) are pivotal in placental develo…
View article: Placental neutrophil reverse trans-migration and maternal serum neutrophil extracellular trap expression in HIV infection co-morbid pre-eclampsia in women of African ancestry
Placental neutrophil reverse trans-migration and maternal serum neutrophil extracellular trap expression in HIV infection co-morbid pre-eclampsia in women of African ancestry Open
Neutrophil extracellular traps (NETs) and placental neutrophil reverse transmigration (r-TM) are implicated in the pathogenesis of pre-eclampsia (PE). However, the role of the comorbidity of PE and human immunodeficiency virus (HIV) infect…
View article: Plasma metabolite profiling for S. haematobium biomarkers of infection in pre-school aged children in Shamva District, Zimbabwe
Plasma metabolite profiling for S. haematobium biomarkers of infection in pre-school aged children in Shamva District, Zimbabwe Open
Background Metabolomics approaches are indispensable tools in infection biomarker discovery efforts as they shed light on the underlying pathophysiological mechanisms of disease. In this study, we analysed plasma metabolites that can be us…
View article: Investigating the efficacy of green solvents and solvent-free conditions in hydrogen-bonding mediated organocatalyzed model reactions
Investigating the efficacy of green solvents and solvent-free conditions in hydrogen-bonding mediated organocatalyzed model reactions Open
The efficacy of green solvents and neat conditions in organocatalysed reactions were investigated. The results suggest cyclopentyl methyl ether and neat conditions could serve as alternatives, potentially enhancing the processes' sustainab…
View article: Standardizing Pre-Clinical Development of Metallo-Β-Lactamase Inhibitors: A Call for Consensus
Standardizing Pre-Clinical Development of Metallo-Β-Lactamase Inhibitors: A Call for Consensus Open
View article: CCDC 2219436: Experimental Crystal Structure Determination
CCDC 2219436: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: N-Arylation of primary and tertiary sulfonimidamides (SIAs) with benzyne precursors under transition metal-free conditions
N-Arylation of primary and tertiary sulfonimidamides (SIAs) with benzyne precursors under transition metal-free conditions Open
Herein, we report an effective and efficient transition metal-free method wherein benzyne intermediates from silyl aryl triflates were successfully coupled with primary sulfonimidamides. The use of CsF in ACN proved to be the optimal condi…
View article: Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors
Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors Open
Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One strategy that exists is to develop β-lactamase inhibitors …
View article: In Vitro and In Vivo Development of a β-Lactam-Metallo-β-Lactamase Inhibitor: Targeting Carbapenem-Resistant <i>Enterobacterales</i>
In Vitro and In Vivo Development of a β-Lactam-Metallo-β-Lactamase Inhibitor: Targeting Carbapenem-Resistant <i>Enterobacterales</i> Open
β-lactams are the most prescribed class of antibiotics due to their potent, broad-spectrum antimicrobial activities. However, alarming rates of antimicrobial resistance now threaten the clinical relevance of these drugs, especially for the…
View article: Special Issue: Advances in the Synthesis of Biologically Important Intermediates/Drugs
Special Issue: Advances in the Synthesis of Biologically Important Intermediates/Drugs Open
Chemical synthesis is a cornerstone of the development of medicinal chemistry, forming the basis for discovering compounds with new physical and/or biological properties [...]
View article: The Binding Potential of Novel NOTA-Based Inhibitors Against Metallo-β-Lactamases IMP-1 and VIM-2: A Molecular Docking and Molecular Dynamics Study
The Binding Potential of Novel NOTA-Based Inhibitors Against Metallo-β-Lactamases IMP-1 and VIM-2: A Molecular Docking and Molecular Dynamics Study Open
View article: Synthesis and biological evaluation of novel β-lactam-metallo β-lactamase inhibitors
Synthesis and biological evaluation of novel β-lactam-metallo β-lactamase inhibitors Open
β-lactamases are enzymes that deactivate β-lactam antibiotics through a hydrolysis mechanism.
View article: Exploring Green Solvents and Solvent-Free Conditions for Sustainable Organocatalysis
Exploring Green Solvents and Solvent-Free Conditions for Sustainable Organocatalysis Open
View article: Computational insights for predicting the binding and selectivity of peptidomimetic plasmepsin IV inhibitors against cathepsin D
Computational insights for predicting the binding and selectivity of peptidomimetic plasmepsin IV inhibitors against cathepsin D Open
Free energy calculations explain the selectivity of peptidomimetic inhibitors to PlmIV and CatD enzymes. Insights for the development of novel potent and selective PlmIV inhibitors are provided.
View article: Peptide microarray analysis of in-silico predicted B-cell epitopes in SARS-CoV-2 sero-positive healthcare workers in Bulawayo, Zimbabwe
Peptide microarray analysis of in-silico predicted B-cell epitopes in SARS-CoV-2 sero-positive healthcare workers in Bulawayo, Zimbabwe Open
View article: The potential of serum S100 calcium-binding protein B and glial fibrillary acidic protein as biomarkers for traumatic brain injury
The potential of serum S100 calcium-binding protein B and glial fibrillary acidic protein as biomarkers for traumatic brain injury Open
View article: Multiplex peptide microarray profiling of antibody reactivity against neglected tropical diseases derived B-cell epitopes for serodiagnosis in Zimbabwe
Multiplex peptide microarray profiling of antibody reactivity against neglected tropical diseases derived B-cell epitopes for serodiagnosis in Zimbabwe Open
Introduction Peptides (B-cell epitopes) have broad applications in disease diagnosis and surveillance of pathogen exposure. In this framework, we present a pilot study to design and produce a peptide microarray for the integrated surveilla…
View article: Antibiotic‐Derived Radiotracers for Positron Emission Tomography: Nuclear or “Unclear” Infection Imaging?
Antibiotic‐Derived Radiotracers for Positron Emission Tomography: Nuclear or “Unclear” Infection Imaging? Open
The excellent features of non‐invasive molecular imaging, its progressive technology (real‐time, whole‐body imaging and quantification), and global impact by a growing infrastructure for positron emission tomography (PET) scanners are enco…
View article: Antibiotic‐Derived Radiotracers for Positron Emission Tomography: Nuclear or “Unclear” Infection Imaging?
Antibiotic‐Derived Radiotracers for Positron Emission Tomography: Nuclear or “Unclear” Infection Imaging? Open
The excellent features of non‐invasive molecular imaging, its progressive technology (real‐time, whole‐body imaging and quantification), and global impact by a growing infrastructure for positron emission tomography (PET) scanners are enco…
View article: Using Antibiotics Scaffolds Will Warrant Novel Radiotracers for Effective Positron Emission Tomography Imaging of Infections: Triumph or Pitfall?
Using Antibiotics Scaffolds Will Warrant Novel Radiotracers for Effective Positron Emission Tomography Imaging of Infections: Triumph or Pitfall? Open
The excellent features of non-invasive molecular imaging, its progressive technology (real-time, whole-body imaging and quantification), and global impact by a growing infrastructure for positron emission tomography (PET) scanners are enco…
View article: The analysis of alcohol content in hand sanitisers (in the Durban region) using gas chromatography-mass spectrometry during the COVID-19 pandemic
The analysis of alcohol content in hand sanitisers (in the Durban region) using gas chromatography-mass spectrometry during the COVID-19 pandemic Open
The COVID-19 pandemic has resulted in an unprecedented surge in the demand for alcohol-based hand sanitisers (ABHS). The Centre for Disease Control (CDC) and World Health Organisation (WHO) recommend alcohol, i.e., isopropanol or ethanol, …
View article: Scoping review of the applications of peptide microarrays on the fight against human infections
Scoping review of the applications of peptide microarrays on the fight against human infections Open
Introduction This scoping review explores the use of peptide microarrays in the fight against infectious diseases. The research domains explored included the use of peptide microarrays in the mapping of linear B-cell and T cell epitopes, a…