Thakur Raghu Raj Singh
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View article: Dacarbazine-loaded Bilayer Dissolving Microneedle Array Patch for Localized Delivery in Cutaneous Melanoma
Dacarbazine-loaded Bilayer Dissolving Microneedle Array Patch for Localized Delivery in Cutaneous Melanoma Open
Melanoma is a highly aggressive skin cancer that accounts for only ~ 1% of all skin cancer cases but is responsible for most skin cancer-related deaths. Despite advances in systemic therapies, localized treatment options remain limited. Da…
View article: Dual-Phase Ocular Insert with Bromfenac-Loaded PLGA MPs in a PVA Matrix for Sustained Postoperative Anti-Inflammatory Delivery
Dual-Phase Ocular Insert with Bromfenac-Loaded PLGA MPs in a PVA Matrix for Sustained Postoperative Anti-Inflammatory Delivery Open
Background: Postoperative ocular inflammation is a frequent complication of eye surgeries commonly managed using corticosteroids or nonsteroidal anti-inflammatory drug (NSAIDs) eye drops. However, poor ocular bioavailability and patient no…
View article: Ocular Drug Delivery: Emerging Approaches and Advances
Ocular Drug Delivery: Emerging Approaches and Advances Open
Complex anatomical and physiological barriers make the eye a challenging organ to treat from a drug delivery perspective. Currently available treatment methods (topical eyedrops) for anterior segment diseases pose several limitations in te…
View article: Emerging trends in long-acting sustained drug delivery for glaucoma management
Emerging trends in long-acting sustained drug delivery for glaucoma management Open
View article: Design and characterization of hollow microneedles for localized intrascleral drug delivery of ocular formulations
Design and characterization of hollow microneedles for localized intrascleral drug delivery of ocular formulations Open
Effective drug delivery to the posterior segment of the eye remains a challenge owing to the limitations of conventional methods such as intravitreal injections, which are associated with significant side effects. This study explored the u…
View article: Development of axitinib-loaded polymeric ocular implants for the treatment of posterior ocular diseases
Development of axitinib-loaded polymeric ocular implants for the treatment of posterior ocular diseases Open
Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are the primary causes of vision impairment and blindness worldwide. The current treatment for these diseases is an intravitreal injection of anti-VEGF agents, which are …
View article: Block copolymer micelles as ocular drug delivery systems
Block copolymer micelles as ocular drug delivery systems Open
Block copolymer micelles, formed by the self-assembly of amphiphilic polymers, address formulation challenges, such as poor drug solubility and permeability. These micelles offer advantages including a smaller size, easier preparation, ste…
View article: Antitoxin nanoparticles: design considerations, functional mechanisms, and applications in toxin neutralization
Antitoxin nanoparticles: design considerations, functional mechanisms, and applications in toxin neutralization Open
The application of nanotechnology has significantly advanced the development of novel platforms that enhance disease treatment and diagnosis. A key innovation in this field is the creation of antitoxin nanoparticles (ATNs), designed to add…
View article: Hollow microneedles for ocular drug delivery
Hollow microneedles for ocular drug delivery Open
Microneedles (MNs) are micron-sized needles, typically <2 mm in length, arranged either as an array or as single needle. These MNs offer a minimally invasive approach to ocular drug delivery due to their micron size (reducing tissue damage…
View article: Cancer Nanovaccines: Nanomaterials and Clinical Perspectives
Cancer Nanovaccines: Nanomaterials and Clinical Perspectives Open
Cancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art in cancer nanovaccine developme…
View article: Design of liposomal nanocarriers with a potential for combined dexamethasone and bevacizumab delivery to the eye
Design of liposomal nanocarriers with a potential for combined dexamethasone and bevacizumab delivery to the eye Open
View article: Curcumin nanocrystals-in-nanofibres as a promising platform for the management of periodontal disease
Curcumin nanocrystals-in-nanofibres as a promising platform for the management of periodontal disease Open
It is estimated that nearly a half of the world's population over 30 years old suffer from some kind of periodontal disease (PD). Although preventable, PD can pose a significant health burden to patients, causing from pain and discomfort t…
View article: Microneedles for advanced ocular drug delivery
Microneedles for advanced ocular drug delivery Open
In the field of ocular drug delivery, topical delivery remains the most common treatment option for managing anterior segment diseases, whileintraocular injectionsare the current gold standard treatment option for treating posterior segmen…
View article: CRISPR/Cas9 Genome Editing for Tissue‐Specific In Vivo Targeting: Nanomaterials and Translational Perspective
CRISPR/Cas9 Genome Editing for Tissue‐Specific In Vivo Targeting: Nanomaterials and Translational Perspective Open
Adv. Sci. 2023, 10, 2207512 DOI: 10.1002/advs.202207512 In the original published article, Satoru Kawakita and Shahid Khan affiliations are swapped. Please find below the correct affiliations. D. K. Sahel Department of Pharmacy Birla Insti…
View article: Long-acting microneedle formulations
Long-acting microneedle formulations Open
View article: Artificial Intelligence in Pharmaceutical Technology and Drug Delivery Design
Artificial Intelligence in Pharmaceutical Technology and Drug Delivery Design Open
Artificial intelligence (AI) has emerged as a powerful tool that harnesses anthropomorphic knowledge and provides expedited solutions to complex challenges. Remarkable advancements in AI technology and machine learning present a transforma…
View article: Ocular application of electrospun materials for drug delivery and cellular therapies
Ocular application of electrospun materials for drug delivery and cellular therapies Open
The constraints of delivering conventional drugs, biologics and cell-based therapeutics to target ocular sites necessitate the fabrication of novel drug delivery systems to treat diverse ocular diseases. Conventional ocular drug delivery a…
View article: Solid implantable devices for sustained drug delivery
Solid implantable devices for sustained drug delivery Open
Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug administration routes. Oral and injectable drug administration are the most common routes for drug delivery providing peaks of drug concentrations …
View article: CRISPR/Cas9 Genome Editing for Tissue‐Specific In Vivo Targeting: Nanomaterials and Translational Perspective
CRISPR/Cas9 Genome Editing for Tissue‐Specific In Vivo Targeting: Nanomaterials and Translational Perspective Open
Clustered randomly interspaced short palindromic repeats (CRISPRs) and its associated endonuclease protein, i.e., Cas9, have been discovered as an immune system in bacteria and archaea; nevertheless, they are now being adopted as mainstrea…
View article: Fabrication and Characterisation of 3D-Printed Triamcinolone Acetonide-Loaded Polycaprolactone-Based Ocular Implants
Fabrication and Characterisation of 3D-Printed Triamcinolone Acetonide-Loaded Polycaprolactone-Based Ocular Implants Open
Triamcinolone acetonide (TA) is a corticosteroid that has been used to treat posterior segment eye diseases. TA is injected intravitreally in the management of neovascular disorders; however, frequent intravitreal injections result in many…
View article: Deferasirox Nanosuspension Loaded Dissolving Microneedles for Intradermal Delivery
Deferasirox Nanosuspension Loaded Dissolving Microneedles for Intradermal Delivery Open
Microneedles are minimally invasive systems that can deliver drugs intradermally without pain and bleeding and can advantageously replace the hypodermal needles and oral routes of delivery. Deferasirox (DFS) is an iron chelator employed in…
View article: Vitreous Humor: Composition, Characteristics and Implication on Intravitreal Drug Delivery
Vitreous Humor: Composition, Characteristics and Implication on Intravitreal Drug Delivery Open
Purpose: Intravitreal administration of drug molecules is one of the most common routes for treating posterior segment eye diseases. However, the properties of vitreous humour changes with the time. A number of ocular complications …
View article: Development and characterization of injectable depot forming thermoresponsive hydrogel for the sustained intrascleral delivery of Sunitinib
Development and characterization of injectable depot forming thermoresponsive hydrogel for the sustained intrascleral delivery of Sunitinib Open
Age-related macular degeneration (AMD) is a potentially blinding posterior segment disease; inflammatory responses and subretinal drusen formation lead to leaky blood vessels. The current treatment method involves intravitreal injections o…
View article: Novel electrospun implants of Sunitinib can depress ex-vivo ocular neovascularization
Novel electrospun implants of Sunitinib can depress ex-vivo ocular neovascularization Open
Choroidal neovascularization (CNV) is one of the hallmark symptoms of Wet Age-related Macular Degeneration (wAMD) and DiabeticRetinopathy(DR) which involves formation of neoangiogenic i.e. formation of new abnormal blood vessels emerging f…
View article: Rapidly dissolving bilayer microneedles enabling minimally invasive and efficient protein delivery to the posterior segment of the eye
Rapidly dissolving bilayer microneedles enabling minimally invasive and efficient protein delivery to the posterior segment of the eye Open
View article: Epidemiologie okulärer Manifestationen bei Autoimmunkrankheiten
Epidemiologie okulärer Manifestationen bei Autoimmunkrankheiten Open
Die weltweite Prävalenz von Autoimmunkrankheiten nimmt zu. Infolgedessen haben auch die mit Autoimmunkrankheiten verbundenen okulären Komplikationen zugenommen, die von leichten Symptomen bis hin zur Bedrohung des Sehvermögens reichen. Die…
View article: Epidemiology of Ocular Manifestations in Autoimmune Disease
Epidemiology of Ocular Manifestations in Autoimmune Disease Open
The global prevalence of autoimmune diseases is increasing. As a result, ocular complications, ranging from minor symptoms to sight-threatening scenarios, associated with autoimmune diseases have also risen. These ocular manifestations can…
View article: In vitro dissolution testing models of ocular implants for posterior segment drug delivery
In vitro dissolution testing models of ocular implants for posterior segment drug delivery Open
The delivery of drugs to the posterior segment of the eye remains a tremendously difficult task. Prolonged treatment in conventional intravitreal therapy requires injections that are administered frequently due to the rapid clearance of th…
View article: Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections
Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections Open
View article: Rapidly Dissolving Microneedle Patch of Amphotericin-B for Intracorneal Fungal Infections.
Rapidly Dissolving Microneedle Patch of Amphotericin-B for Intracorneal Fungal Infections. Open
Chronic fungal infection of the cornea could lead to blindness if not treated properly. Topical AMP-B is considered the first treatment of choice for ocular fungal infection. However, factors related to its poor solubility and penetration …