Thanos D. Papakostas
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View article: The Influence of Ultra-Widefield Fluorescein Angiography on the Diagnosis and Management of Diabetic Retinopathy
The Influence of Ultra-Widefield Fluorescein Angiography on the Diagnosis and Management of Diabetic Retinopathy Open
Purpose: To study the influence of ultra-widefield fluorescein angiography (FA) on the diagnosis and management of diabetic retinopathy (DR). Methods: Ten experts in DR completed an online survey in which they were asked to diagnose and ma…
View article: Multimodal Imaging of a Unique Transitory Finding in Ocular Syphilis
Multimodal Imaging of a Unique Transitory Finding in Ocular Syphilis Open
Purpose: To describe a unique finding in ocular syphilis using multimodal imaging. Methods: A single case was analyzed. Results: A 52-year-old man presented with chronic syphilitic posterior uveitis and was treated with intravenous and int…
View article: TECHNIQUE FOR REMOVAL OF A GANCICLOVIR IMPLANT DISLOCATED IN THE VITREOUS CAVITY
TECHNIQUE FOR REMOVAL OF A GANCICLOVIR IMPLANT DISLOCATED IN THE VITREOUS CAVITY Open
Purpose: To report a technique to remove a dislocated ganciclovir implant in the vitreous cavity. Methods: Retrospective case series. Two patients with dislocated ganciclovir implants in the vitreous cavity. Results: A 6-mm pars plana inci…
View article: Optical Coherence Tomography Angiography: Clinical Utility and Future Directions
Optical Coherence Tomography Angiography: Clinical Utility and Future Directions Open
Purpose: This work aims to review the principles of optical coherence tomography angiography (OCTA), to survey its clinical utility, and to highlight the strengths of this technology as well as barriers to adoption. Methods: A literature r…
View article: Didanosine-Associated Retinal Toxicity in a Patient With a Mutation in the <i>CRB1</i> Gene
Didanosine-Associated Retinal Toxicity in a Patient With a Mutation in the <i>CRB1</i> Gene Open
Purpose: This article describes a case of didanosine (DDI)-associated retinal toxicity in a patient with a heterozygous pathogenic variant in the CRB1 gene. Methods: Case report. Results: A middle-aged patient with HIV controlled on HAART …
View article: Feasibility and Clinical Utility of Ultra-Widefield–Navigated Swept-Source Optical Coherence Tomography Imaging
Feasibility and Clinical Utility of Ultra-Widefield–Navigated Swept-Source Optical Coherence Tomography Imaging Open
Purpose: This work aims to evaluate the clinical utility and feasibility of a novel scanning laser ophthalmoscope-based navigated ultra-widefield swept-source optical coherence tomography (UWF SS-OCT) imaging system. Methods: A retrospecti…
View article: Choroidal Neovascularization and Macular Hemorrhage: Real-World Experience During the New York City COVID-19 Lockdown
Choroidal Neovascularization and Macular Hemorrhage: Real-World Experience During the New York City COVID-19 Lockdown Open
Purpose: This work reviews ocular, systemic, and demographic factors contributing to presentation of choroidal neovascular membrane (CNVM)–associated macular hemorrhage after the New York City coronavirus disease 2019 (COVID-19) lockdown. …
View article: Current intravitreal therapy and ocular hypertension
Current intravitreal therapy and ocular hypertension Open
To determine the effect of commonly used intravitreal agents on immediate and long-term IOP elevations and their association, if any, with glaucoma. Literature searches in PubMed and the Cochrane databased in January 2020 yielded 407 indiv…
View article: Outcomes of primary rhegmatogenous retinal detachment repair with extensive scleral-depressed vitreous removal and dynamic examination
Outcomes of primary rhegmatogenous retinal detachment repair with extensive scleral-depressed vitreous removal and dynamic examination Open
There are multiple surgical approaches to the repair of rhegmatogenous retinal detachment (RRD). Here, we evaluated the outcomes of small-gauge pars plana vitrectomy (PPV), alone or in combination with scleral buckle (SB-PPV), for RRD repa…
View article: <p>Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography</p>
Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography Open
In macula-off RRD eyes, significant microvascular changes were detected in the DCP using OCT-A even after successful anatomical repair. Decreased VD in the DCP compared to the fellow healthy eyes was correlated with worse visual acuity.
View article: <p>Comorbid hepatitis C does not modulate prevalence or severity of diabetic retinopathy</p>
Comorbid hepatitis C does not modulate prevalence or severity of diabetic retinopathy Open
In this study, comorbid HCV did not modulate the prevalence or severity of DR among patients with DM. These findings may inform clinical monitoring among HCV-positive diabetics undergoing ophthalmic evaluation.
View article: Perfluorocarbon liquid-assisted intraocular foreign body removal
Perfluorocarbon liquid-assisted intraocular foreign body removal Open
We describe the benefits of perfluoro-N-octane (PFO), a perfluorocarbon liquid, in the removal of nonmagnetic intraocular foreign bodies (IOFBs) from the macula and posterior segment. Two consecutive cases of posterior segment IOFB were re…
View article: Evaluation of choroidal lesions with swept-source optical coherence tomography
Evaluation of choroidal lesions with swept-source optical coherence tomography Open
Aims The aim of our study was to image choroidal lesions with swept-source optical coherence tomography (SS-OCT) and to identify the morphological characteristics associated with optimal visualisation. Methods This was a prospective, cross…
View article: Genetic Risk Factors for Radiation Vasculopathy
Genetic Risk Factors for Radiation Vasculopathy Open
Visual loss from radiation vasculopathy after treatment for choroidal melanoma is not only related to tumor location but may be influenced by hypertension and possibly genetic factors.
View article: Early Neuroblastic and Astrocytic Differentiation Demonstrated Immunohistochemically in a Small Intraocular Medulloepithelioma
Early Neuroblastic and Astrocytic Differentiation Demonstrated Immunohistochemically in a Small Intraocular Medulloepithelioma Open
Purpose: To investigate the source of fibrous astrocytes and neuroblasts in a small ciliary body medulloepithelioma appearing as a leukocoria in a 3-week-old baby girl. Methods: Histopathologic and immunohistochemical studies included Alci…
View article: Long-term Outcomes After Proton Beam Irradiation in Patients With Large Choroidal Melanomas
Long-term Outcomes After Proton Beam Irradiation in Patients With Large Choroidal Melanomas Open
This study demonstrates that eye conservation is possible in most cases, with ambulatory vision retained in a small proportion of patients 10 years after PBI. Tumor recurrence rates were low and mortality rates were comparable to those obs…
View article: Optical coherence tomography findings and successful repair of retina detachment in Knobloch syndrome
Optical coherence tomography findings and successful repair of retina detachment in Knobloch syndrome Open
A 7-year-old Afghani girl was referred to the retina clinic of Massachusetts Eye and Ear for a chronic-appearing, macula-off retinal detachment in the left eye. On examination, best-corrected visual acuity was 20/400 in the right eye and 2…
View article: Indications and Techniques of Endoscope Assisted Vitrectomy
Indications and Techniques of Endoscope Assisted Vitrectomy Open
The popularization of ophthalmic endoscopy has been promoted by recent technological advancements that increase the number of indications for endoscopy. These advancements have improved the endoscope’s capabilities in its two fundamental s…
View article: Multiple simultaneous choroidal melanomas arising in the same eye: globe salvage by radiotherapy
Multiple simultaneous choroidal melanomas arising in the same eye: globe salvage by radiotherapy Open
Purpose Multiple choroidal melanomas arising in the same eye is a very rare entity, usually leading ophthalmologists to entertain other diagnoses. Historically, the only available treatment reported for this rare entity was enucleation. In…
View article: Clinical trials in retinal dystrophies
Clinical trials in retinal dystrophies Open
Research development is burgeoning for genetic and cellular therapy for retinal dystrophies. These dystrophies are the focus of many research efforts due to the unique biology and accessibility of the eye, the transformative advances in oc…