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View article: Expression of Activating KIR2DS2 and KIR2DS4 Genes after Hematopoietic Cell Transplantation: Relevance to Cytomegalovirus Infection
Expression of Activating KIR2DS2 and KIR2DS4 Genes after Hematopoietic Cell Transplantation: Relevance to Cytomegalovirus Infection Open
The important role of activating killer immunoglobulin-like receptors (KIRs) in protecting against cytomegalovirus (CMV) reactivation has been described previously in patients undergoing hematopoietic cell transplantation (HCT). More speci…
View article: Biologic and Immunologic Effects of Knockout of Human Cytomegalovirus pp65 Nuclear Localization Signal
Biologic and Immunologic Effects of Knockout of Human Cytomegalovirus pp65 Nuclear Localization Signal Open
The human cytomegalovirus (CMV) pp65 protein contains two bipartite nuclear localization signals (NLSs) at amino acids (aa) 415 to 438 and aa 537 to 561 near the carboxy terminus of CMV pp65 and a phosphate binding site related to kinase a…
View article: Impact of donor CMV status on viral infection and reconstitution of multifunction CMV-specific T cells in CMV-positive transplant recipients
Impact of donor CMV status on viral infection and reconstitution of multifunction CMV-specific T cells in CMV-positive transplant recipients Open
Reconstitution of cytomegalovirus (CMV)–specific CD8+ T cells is essential to the control of CMV infection in CMV-positive recipients (R+) after allogeneic hematopoietic stem cell transplantation (HCT). Six-color flow cytometry was used to…
View article: 393: Presence of Activating KIR Genotypes Influences Cytomegalovirus (CMV) Reactivation as Detected by Q-PCR in HCT Recipients
393: Presence of Activating KIR Genotypes Influences Cytomegalovirus (CMV) Reactivation as Detected by Q-PCR in HCT Recipients Open
Killer Ig-like receptor (KIR) is a cluster of natural killer cell receptors presented by T cells and natural killer (NK) cells. The compatibility of these receptors between the donor and the recipient plays a role in hematopoietic cell tra…
View article: 402: PD-1 Expression is Linked to CMV Disease and Prolonged CMV Infection after HCT
402: PD-1 Expression is Linked to CMV Disease and Prolonged CMV Infection after HCT Open
PD-1 expression has been linked to chronic viral infection in both mice (Barber DL et al, Nature 2006, 7077: 682–7) and man (Trautmann L et al Nat Med.2006; 10:1198–202). Although PD-1 expression has not been shown to be up-regulated in CM…
View article: Functional Comparison of T Cells Recognizing Cytomegalovirus pp65 and Intermediate‐Early Antigen Polypeptides in Hematopoietic Stem‐Cell Transplant and Solid Organ Transplant Recipients
Functional Comparison of T Cells Recognizing Cytomegalovirus pp65 and Intermediate‐Early Antigen Polypeptides in Hematopoietic Stem‐Cell Transplant and Solid Organ Transplant Recipients Open
The functional status of cytotoxic T lymphocyte (CTL) populations recognizing cytomegalovirus intermediate-early antigen (IE1) and pp65 polypeptides was investigated in peripheral blood mononuclear cells from hematopoietic stem-cell transp…
View article: Simultaneous Reconstitution of Multiple Cytomegalovirus‐Specific CD8<sup>+</sup>Cell Populations with Divergent Functionality in Hematopoietic Stem‐Cell Transplant Recipients
Simultaneous Reconstitution of Multiple Cytomegalovirus‐Specific CD8<sup>+</sup>Cell Populations with Divergent Functionality in Hematopoietic Stem‐Cell Transplant Recipients Open
A panel of 7 human cytomegalovirus (CMV) epitope peptides and corresponding major histocompatibility class 1 tetramers was used to evaluate cellular immunity in healthy seropositive donors and in hematopoietic stem-cell transplant recipien…