Thein Hlaing Oo
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View article: Exploring Small-Molecule Inhibitors of Glucosidase II: Advances, Challenges, and Therapeutic Potential in Cancer and Viral Infection
Exploring Small-Molecule Inhibitors of Glucosidase II: Advances, Challenges, and Therapeutic Potential in Cancer and Viral Infection Open
Glucosidase II (GluII) is a heterodimeric enzyme localized in the endoplasmic reticulum (ER), essential for the sequential trimming of glucose residues during N-linked glycosylation. This critical function facilitates glycoprotein folding …
View article: MiR-125b-5p and miR-100-5p as Biomarkers and therapeutic targets for the prevention of particulate matter-induced non-smoker lung cancer
MiR-125b-5p and miR-100-5p as Biomarkers and therapeutic targets for the prevention of particulate matter-induced non-smoker lung cancer Open
Non-smoking-related lung cancer is increasingly associated with environmental factors such as particulate matter (PM) exposure. Using deep small RNA sequencing, we identified distinct miRNA expression patterns in lung cancer patients compa…
View article: Systematic review and meta-analysis of randomized controlled trials on outpatient thromboprophylaxis (OTP) in patients with cancers with khorana score (KS) ≥ 2 receiving chemotherapy
Systematic review and meta-analysis of randomized controlled trials on outpatient thromboprophylaxis (OTP) in patients with cancers with khorana score (KS) ≥ 2 receiving chemotherapy Open
Introduction: Thrombosis is a major concern for patients with cancers. Cancers with the KS ≥ 2 are highly thrombogenic cancers. Outpatient thromboprophylaxis is currently suggested for such patients by recent clinical practice guidelines. …
View article: The impact of viral pneumonia on hospital outcomes in sickle cell disease: A database review and analysis
The impact of viral pneumonia on hospital outcomes in sickle cell disease: A database review and analysis Open
Introduction: Sickle cell disease (SCD) is a subset of hereditary hemoglobinopathies characterized by chronic hemolysis, vaso-occlusion, and multiorgan complications. Among the concerned complications of vaso-occlusive crisis, acute chest …
View article: The national burden of opoid use disorder on hospital outcomes in sickle cell disease: A database review and analysis
The national burden of opoid use disorder on hospital outcomes in sickle cell disease: A database review and analysis Open
Introduction: Sickle cell disease (SCD) affects approximately 100,000 individuals in the U.S. and frequently leads to hospitalizations for complications like vaso-occlusive crisis. Opioids are central to acute pain management but raise con…
View article: A 54-Years-Old Man Known Case of Hypertension, Diabetes Mellitus, Obesity Having Pyogenic Meningitis Due to Streptococcus Agalactiea Complicated by Multiple Small Abscesses Over Meninges, Metabolic Acidosis, Acute Kidney Injury, Transaminitis, DIC And ARD
A 54-Years-Old Man Known Case of Hypertension, Diabetes Mellitus, Obesity Having Pyogenic Meningitis Due to Streptococcus Agalactiea Complicated by Multiple Small Abscesses Over Meninges, Metabolic Acidosis, Acute Kidney Injury, Transaminitis, DIC And ARD Open
A 54-years-old man presented with 3 days history of fever and headache followed by acute confusion. He was a known case of hypertension and diabetes mellitus for 10 years. He was obese; neck rigidity was noted; Glasgow Coma Scale was 9/15 …
View article: Hyperhomocysteinemia-associated Thrombosis in Patients With Pernicious Anemia
Hyperhomocysteinemia-associated Thrombosis in Patients With Pernicious Anemia Open
This rare condition is associated with high incidence of thromboses at unusual sites, multiple-site thromboses, co-existing neuropsychiatric symptoms, high positivity rate for anti-IF antibodies and low recurrent thrombosis rate.
View article: P1646: A SYSTEMATIC REVIEW AND META‐ANALYSIS OF RANDOMIZED CONTROLLED TRIALS ON PRIMARY AMBULATORY THROMBOPROPHYLAXIS (PATP) IN PATIENTS WITH LYMPHOMA RECEIVING CHEMOTHERAPY
P1646: A SYSTEMATIC REVIEW AND META‐ANALYSIS OF RANDOMIZED CONTROLLED TRIALS ON PRIMARY AMBULATORY THROMBOPROPHYLAXIS (PATP) IN PATIENTS WITH LYMPHOMA RECEIVING CHEMOTHERAPY Open
Topic: 34. Thrombosis and vascular biology - Biology & Translational Research Background: Venous thromboembolism (VTE) is a frequent complication of cancer and cancer treatment. Lymphoma is a highly thrombogenic cancer according to the Kho…
Updated meta-analysis of randomized controlled trials on primary outpatient thromboprophylaxis in patients with gastric and gastroesophageal junction cancers receiving chemotherapy Open
Advanced gastric cancer is a highly thrombogenic cancer per Khorana score. Recent clinical practice guidelines suggest primary outpatient thromboprophylaxis (POTP) for patients with a Khorana score ≥2. We performed an updated meta-analysis…
View article: Meta-analysis of randomized controlled trials on primary ambulatory thromboprophylaxis in patients with ovarian cancer receiving chemotherapy
Meta-analysis of randomized controlled trials on primary ambulatory thromboprophylaxis in patients with ovarian cancer receiving chemotherapy Open
Ovarian cancer (OC) is highly associated with venous thromboembolism (VTE). The OC cells stimulate thrombin generation, and chemotherapy potentiates the prothrombotic effect of cancer cells by damaging endothelium and enhancing hypercoagul…
View article: Meta-analysis of randomized controlled trials on primary ambulatory thromboprophylaxis in patients with nonpancreatic gastrointestinal cancers receiving chemotherapy
Meta-analysis of randomized controlled trials on primary ambulatory thromboprophylaxis in patients with nonpancreatic gastrointestinal cancers receiving chemotherapy Open
Primary ambulatory thromboprophylaxis (PATP) in patients with solid malignancies is not routinely indicated. We performed a meta-analysis of randomized controlled trials (RCTs) to determine the benefit and risk of PATP in patients with non…
View article: Risk of pulmonary emboli after removal of an upper extremity central catheter associated with a deep vein thrombosis
Risk of pulmonary emboli after removal of an upper extremity central catheter associated with a deep vein thrombosis Open
Standard treatment of catheter-associated upper extremity deep vein thrombosis (UE-DVT) is anticoagulation, although catheters are often removed for this indication. The optimal time for catheter removal and whether the act and/or timing o…
View article: Secondary erythrocytosis due to hemoglobin San Diego
Secondary erythrocytosis due to hemoglobin San Diego Open
High-oxygen-affinity hemoglobin variants are a rare clinical entity that can present with secondary erythrocytosis. Herein, the author reports a case of a 41-year-old man with a 4-year history of secondary erythrocytosis of unknown etiolog…
View article: Bleeding outcomes in thrombocytopenic acute leukemic patients with venous thromboembolism
Bleeding outcomes in thrombocytopenic acute leukemic patients with venous thromboembolism Open
Cancer‐associated thrombosis in acute leukemia patients with severe thrombocytopenia (platelets ≤50 × 10 9 /L) poses a management challenge due to competing risks of bleeding and recurrent thrombosis. A retrospective analysis was conducted…
View article: Identifying Hemostatic Thresholds in Cancer Patients Undergoing Coronary Angiography Based on Platelet Count and Thromboelastography
Identifying Hemostatic Thresholds in Cancer Patients Undergoing Coronary Angiography Based on Platelet Count and Thromboelastography Open
Objectives: To evaluate the role of platelet count and thromboelastogram (TEG) in the treatment of thrombocytopenic cancer patients with suspected coronary artery disease (CAD). Background: Cancer patients with CAD and thrombocytopenia are…
View article: Gaucher disease type 1 first recognized in an elderly patient with thrombocytopenia and lung adenocarcinoma
Gaucher disease type 1 first recognized in an elderly patient with thrombocytopenia and lung adenocarcinoma Open
Recognizing Gaucher disease in elderly patients can be challenging. We present a Gaucher disease type 1 case diagnosed in an elderly patient with thrombocytopenia and lung adenocarcinoma. The diagnosis of Gaucher disease was delayed due to…
View article: Clinical and laboratory features of autoimmune hemolytic anemia associated with immune checkpoint inhibitors
Clinical and laboratory features of autoimmune hemolytic anemia associated with immune checkpoint inhibitors Open
Immune checkpoint inhibitors (ICPis) are a novel class of immunotherapeutic agents that have revolutionized the treatment of cancer; however, these drugs can also cause a unique spectrum of autoimmune toxicity. Autoimmune hemolytic anemia …
View article: Acquired amegakaryocytic thrombocytopenia and red cell aplasia in a patient with thymoma progressing to aplastic anemia successfully treated with allogenic stem cell transplantation
Acquired amegakaryocytic thrombocytopenia and red cell aplasia in a patient with thymoma progressing to aplastic anemia successfully treated with allogenic stem cell transplantation Open
Association of pure red-cell aplasia with thymoma is well documented. However, acquired amegakaryocytic thrombocytopenia (AAMT) has been rarely associated with thymoma with only five reported cases in literature. We report a patient with t…
View article: Frequency of venous thromboembolism events during acute inpatient rehabilitation in a comprehensive cancer centre
Frequency of venous thromboembolism events during acute inpatient rehabilitation in a comprehensive cancer centre Open
Cancer patients with low FIM transfer scores and lower extremity oedema are at higher risk of venous thromboembolism. Patients with these clinical findings at admission may require measures for more aggressive surveillance for the presence…
View article: Copper deficiency‐related bone marrow changes secondary to long‐term total parenteral nutrition
Copper deficiency‐related bone marrow changes secondary to long‐term total parenteral nutrition Open
Key Clinical Message Total parenteral nutrition can be complicated by the marrow sea‐blue histiocytes as well as copper deficiency‐related bone marrow changes. Cytoplasmic vacuoles in the erythroid and myeloid precursors raise the possibil…
View article: Performance of 4T score and HIT Antibody in the Diagnosis of Heparin-Induced Thrombocytopenia in Cancer Patients
Performance of 4T score and HIT Antibody in the Diagnosis of Heparin-Induced Thrombocytopenia in Cancer Patients Open
Objectives: Cancer patients may have relatively higher risk of HIT-related complications, yet data on HIT in cancer are limited. Though cancer patients have characteristics which significantly influence the 4T score and HIT antibody (ab), …
View article: Successful treatment of aplastic anemia–paroxysmal nocturnal hemoglobinuria associated with eosinophilic fasciitis with matched unrelated donor allogeneic peripheral blood stem cell transplantation
Successful treatment of aplastic anemia–paroxysmal nocturnal hemoglobinuria associated with eosinophilic fasciitis with matched unrelated donor allogeneic peripheral blood stem cell transplantation Open
Key Clinical Message We report the first patient case of successful treatment intervention for both eosinophilic fasciitis and aplastic anemia with allogeneic peripheral blood stem cell transplantation from a matched unrelated donor after …