Explanipedia

Adaptive Thermogenesis Driving Catch-Up Fat Is Associated With Increased Muscle Type 3 and Decreased Hepatic Type 1 Iodothyronine Deiodinase Activities: A Functional and Proteomic Study Open

Celia Di Munno, Rosa Anna Busiello, Julie Calonne, Anna Maria Salzano, Jennifer L. Miles‐Chan , et al. · 2021

Refeeding after caloric restriction induces weight regain and a disproportionate recovering of fat mass rather than lean mass (catch-up fat) that, in humans, associates with higher risks to develop chronic dysmetabolism. Studies in a well-…

Unique near-complete deletion of GLI2 in a patient with combined pituitary hormone deficiency and post-axial polydactyly Open

Melitza Elizabeth, Annemieke J.M.H. Verkerk, Anita C. S. Hokken‐Koelega, Joost Verlouw, Jesús Argente , et al. · 2019

The <i>In Vitro</i> Functional Impairment of Thyroid Hormone Receptor Alpha 1 Isoform Mutants Is Mainly Dictated by Reduced Ligand Sensitivity Open

Karn Wejaphikul, Anja L.M. van Gucht, Stefan Groeneweg, W. Edward Visser, Theo J. Visser , et al. · 2019

Background: Thyroid hormone (TH) acts on TH receptors (TRs) and regulates gene transcription by binding of TRs to TH response elements (TREs) in target gene promoters. The transcriptional activity of TRs is modulated by inter…

Effectiveness and safety of the tri-iodothyronine analogue Triac in children and adults with MCT8 deficiency: an international, single-arm, open-label, phase 2 trial Open

Stefan Groeneweg, Robin P. Peeters, Carla Moran, Athanasia Stoupa, Françoise Auriol , et al. · 2019

Role of Leucine 341 in Thyroid Hormone Receptor Beta Revealed by a Novel Mutation Causing Thyroid Hormone Resistance Open

Karn Wejaphikul, Stefan Groeneweg, Prapai Dejkhamron, Kevalee Unachak, W. Edward Visser , et al. · 2018

Leucine 341 has been predicted from crystal structure as an important residue for thyroid hormone receptor beta (TRβ) function, but this has never been confirmed in functional studies. Here, a novel p.L341V mutation as a cause of resistanc…

Mutated Thyroid Hormone Transporter OATP1C1 Associates with Severe Brain Hypometabolism and Juvenile Neurodegeneration Open

Petter Strømme, Stefan Groeneweg, Elaine C. Souza, Chantal Zevenbergen, Anette Torgersbråten , et al. · 2018

This is the first report of human OATP1C1 deficiency compatible with brain-specific hypothyroidism and neurodegeneration.

The pyriproxyfen metabolite 4'OH- pyriproxyfen disrupts thyroid hormone signaling and enhances Musashi-1 levels in neuroprogenitors. Open

Petra Špirhanzlová, Sébastien Le Mével, Karn Wejaphikul, Bilal B. Mughal, Jean‐David Gothié , et al. · 2018

Epidemiological and experimental studies have raised questions as to whether the insecticide pyriproxyfen (PPF) could be implicated in the increased incidence of microcephaly associated with ZIKA infection during pregnancy. This pesticide …

Multiple effects of cold exposure on livers of male mice Open

Aldo Grefhorst, Johanna C van den Beukel, Wieneke Dijk, Jacobie Steenbergen, Gardi Voortman , et al. · 2018

Cold exposure of mice is a common method to stimulate brown adipose tissue (BAT) activity and induce browning of white adipose tissue (WAT) that has beneficial effects on whole-body lipid metabolism, including reduced plasma triglyceride (…

Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10) Open

David S. Sharlin, Lily Ng, François Verrey, Theo J. Visser, Ye Liu , et al. · 2018

Effects of Chemical Chaperones on Thyroid Hormone Transport by MCT8 Mutants in Patient-Derived Fibroblasts Open

Stefan Groeneweg, Amanda van den Berge, Marcel E. Meima, Robin P. Peeters, Theo J. Visser , et al. · 2018

Mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8) result in severe intellectual and motor disability. At present, no effective therapy is available to restore TH signaling in MCT8-dependent tissues. Rec…

Genetic screening of regulatory regions of pituitary transcription factors in patients with idiopathic pituitary hormone deficiencies Open

Melitza Elizabeth, Anita C. S. Hokken‐Koelega, Joyce Schuilwerve, Robin P. Peeters, Theo J. Visser , et al. · 2017

Although the new POU1F1 variant might explain the phenotype of one patient, the general conclusion of this study is that variants in regulatory regions of PROP1, POU1F1 and HESX1 are rare in patients with sporadic CPHD in the Netherlands. …

The Association of Thyroid Function With Maternal and Neonatal Homocysteine Concentrations Open

M Barjaktarović, Eric A.P. Steegers, Vincent W. V. Jaddoe, Yolanda B. de Rijke, Theo J. Visser , et al. · 2017

Higher thyroid function is associated with higher homocysteine concentrations in pregnant women and in neonates. These data provide new insights into the effects of thyroid hormone on folate- and vitamin B12-dependent processes during earl…

Role of the Bile Acid Transporter SLC10A1 in Liver Targeting of the Lipid-Lowering Thyroid Hormone Analog Eprotirome Open

Simone Kersseboom, Anja L.M. van Gucht, Alies van Mullem, Giulia Brigante, Stefania Farina , et al. · 2017

The thyroid hormone (TH) analog eprotirome (KB2115) was developed to lower cholesterol through selective activation of the TH receptor (TR) β1 in the liver. Interestingly, eprotirome shows low uptake in nonhepatic tissues, explaining its l…

Anemia in Patients With Resistance to Thyroid Hormone α: A Role for Thyroid Hormone Receptor α in Human Erythropoiesis Open

Anja L.M. van Gucht, Marcel E. Meima, Carla Moran, Maura Agostini, Anna Tylki‐Szymańska , et al. · 2017

Context Patients with resistance to thyroid hormone (TH) α (RTHα) are characterized by growth retardation, macrocephaly, constipation, and abnormal thyroid function tests. In addition, almost all RTHα patients have mild anemia, the pathoge…

Outward-Open Model of Thyroid Hormone Transporter Monocarboxylate Transporter 8 Provides Novel Structural and Functional Insights Open

Stefan Groeneweg, Elaine C. Souza, Marcel E. Meima, Robin P. Peeters, W. Edward Visser , et al. · 2017

Monocarboxylate transporter 8 (MCT8) facilitates cellular uptake and efflux of thyroid hormone (TH). Mutations in MCT8 result in severe intellectual and motor disability known as the Allan-Herndon-Dudley syndrome (AHDS). Previous studies h…

Thyroid Function and Premature Delivery in TPO Antibody−Negative Women: The Added Value of hCG Open

Tim I.M. Korevaar, Eric A.P. Steegers, Layal Chaker, Marco Medici, Vincent W. V. Jaddoe , et al. · 2017

In TPOAb-negative women with high-normal TSH concentrations, only women with high hCG concentrations had a higher risk of premature delivery or pPROM. These results suggest a lower thyroidal response to hCG stimulation is also associated w…

Genetic analysis of IRF6, a gene involved in craniofacial midline formation, in relation to pituitary and facial morphology of patients with idiopathic growth hormone deficiency Open

Eline Starink, Anita C. S. Hokken‐Koelega, Theo J. Visser, Janneke Baan, Robin P. Peeters , et al. · 2017

Functional Characterization of Xenopus Thyroid Hormone Transporters mct8 and oatp1c1 Open

Bilal B. Mughal, Michelle Leemans, Elaine C. Souza, Sébastien Le Mével, Petra Špirhanzlová , et al. · 2017

Xenopus is an excellent model for studying thyroid hormone signaling as it undergoes thyroid hormone–dependent metamorphosis. Despite the fact that receptors and deiodinases have been described in Xenopus, membrane transporters for these h…

Triiodothyroacetic acid in health and disease Open

Stefan Groeneweg, Robin P. Peeters, Theo J. Visser, W. Edward Visser · 2017

Thyroid hormone (TH) is crucial for development and metabolism of many tissues. The physiological relevance and therapeutic potential of TH analogs have gained attention in the field for many years. In particular, the relevance and use of …

Sorafenib-Induced Changes in Thyroid Hormone Levels in Patients Treated for Hepatocellular Carcinoma Open

Carolien Beukhof, Leni van Doorn, Theo J. Visser, Sander Bins, W. Edward Visser , et al. · 2017

These in vivo data suggest that sorafenib affects TFTs on multiple levels. Our in vitro experiments suggest a possible role of sorafenib-induced inhibition of T3 transport into the cell by MCT8 and MCT10.

Thyroid autoimmunity impairs the thyroidal response to hCG: two population-based prospective cohort studies Open

Tim I.M. Korevaar, Eric A.P. Steegers, Victor J.M. Pop, Maarten A.C. Broeren, Layal Chaker , et al. · 2016

TPOAb-positive women display an impaired thyroidal response to hCG and this may explain the higher risk of premature delivery in these women. This abnormal response in TPOAb-positive women might suggest that these women require a different…

The Risk of Preeclampsia According to High Thyroid Function in Pregnancy Differs by hCG Concentration Open

Tim I.M. Korevaar, Eric A.P. Steegers, Layal Chaker, Marco Medici, Vincent W. V. Jaddoe , et al. · 2016

Context: During pregnancy, there is an increased demand for thyroid hormone. The pregnancy hormone human chorionic gonadotropin (hCG) is an important physiological stimulator of thyroid function. Already high-normal maternal free T4 concen…

Serum Thyroid Function, Mortality and Disability in Advanced Old Age: The Newcastle 85+ Study Open

Simon H. S. Pearce, Salman Razvi, Mohammad E Yadegarfar, Carmen Martin‐Ruiz, Andrew Kingston , et al. · 2016

Our study is reassuring that individuals age 85 y with both subclinical hypothyroidism and subclinical hyperthyroidism do not have a significantly worse survival over 9 years than their euthyroid peers. However, thyroid function tests did …

The importance of maternal thyroid for the placental function Open

M Barjaktarović, Tim I.M. Korevaar, Vincent W. V. Jaddoe, Rijke Yolanda de, Theo J. Visser , et al. · 2016

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Sorafenib-induced changes in thyroid hormone levels in patients with hepatocellular carcinoma Open

Carolien Beukhof, Sander Bins, Doorn Leni van, Herder Wouter de, Theo J. Visser , et al. · 2016

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Diverse Genotypes and Phenotypes of Three Novel Thyroid Hormone Receptor-α Mutations Open

Korcan Demir, Anja L.M. van Gucht, Muammer Büyükinan, Gönül Çatlı, Yavuz Ayhan , et al. · 2016

Context: Recently several patients with resistance to thyroid hormone (RTH)-α due to T3 receptor-α (TRα) mutations were identified. The phenotype of these patients consists of varying degrees of growth impairment, delayed bone, mental and …

Characterization of Chicken Thyroid Hormone Transporters Open

Nele Bourgeois, Stijn L. J. Van Herck, Pieter Vancamp, Joke Delbaere, Chantal Zevenbergen , et al. · 2016

Thyroid hormone (TH) transmembrane transporters are key regulators of TH availability in target cells where correct TH signaling is essential for normal development. Although the chicken embryo is a valuable model for developmental studies…

Selenium Status Is Positively Associated with Bone Mineral Density in Healthy Aging European Men Open

Carolien Beukhof, Marco Medici, Annewieke W. van den Beld, Birgit Hollenbach, Antonia Hoeg , et al. · 2016

Our study demonstrates that Se status, within the normal European marginally supplied range, is positively associated with BMD in healthy aging men, independent of thyroid function. Thyroid function tests appear unaffected by Se status in …

Thyroid dysfunction and breast cancer risk — an unfinished story Open

Layal Chaker, Theo J. Visser · 2016

Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging Open

W. Edward Visser, Cíntia R. Bombardieri, Chantal Zevenbergen, Sander Barnhoorn, Alexandre Ottaviani , et al. · 2016

DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive. Since thyroid hormone (TH) is a key r…

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