Théoden I. Netoff
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View article: Neuropacify: A method to transform and match a patient's intracranial EEG to their NeuroPace RNS System data
Neuropacify: A method to transform and match a patient's intracranial EEG to their NeuroPace RNS System data Open
Objective: Closed-loop responsive neurostimulators, such as the NeuroPace Responsive Neurostimulation (RNS) System, continuously monitor brain activity and deliver electrical stimulation in response to abnormal electrographic activity in p…
View article: An augmented preference-based Bayesian approach for optimizing neuromodulation stimulation parameters using meta learning
An augmented preference-based Bayesian approach for optimizing neuromodulation stimulation parameters using meta learning Open
Background: Electrical neuromodulation is increasingly used in the treatment of neurological disorders; however, the selection of stimulation parameters that provide optimal therapeutic benefits remains a major challenge. Moreover, identif…
View article: Rhythms in Longitudinal Thalamic Recordings are Linked to Seizure Risk
Rhythms in Longitudinal Thalamic Recordings are Linked to Seizure Risk Open
Objectives Seizure unpredictability remains a major clinical challenge for people with epilepsy. Previous works have shown that seizure risk is associated with circadian and multi-day cycles in both brain and physiological signals. However…
View article: Slow Gamma Suppression Correlates with Therapeutic Response to Anterior Thalamic Deep Brain Stimulation in Intractable Epilepsy
Slow Gamma Suppression Correlates with Therapeutic Response to Anterior Thalamic Deep Brain Stimulation in Intractable Epilepsy Open
In drug-resistant epilepsy patients who undergo anterior thalamic deep brain stimulation (ANT-DBS), efficacy is assessed months after therapy initiation and clinicians have no guidance when choosing stimulation parameters due to the lack o…
View article: Personalized Adaptive Cortical Electro-stimulation (PACE) in Treatment-Resistant Depression
Personalized Adaptive Cortical Electro-stimulation (PACE) in Treatment-Resistant Depression Open
Treatment-resistant depression (TRD) is a leading cause of premature death. For decades investigators have assessed the clinical efficacy of direct brain stimulation for TRD. Outcomes have been inconsistent due to imprecise brain targeting…
View article: Prefrontal Cortical Stimulation for Treatment-Resistant Depression
Prefrontal Cortical Stimulation for Treatment-Resistant Depression Open
View article: Metric Validation for Detection of Delayed and Directed Coupling
Metric Validation for Detection of Delayed and Directed Coupling Open
Background: The brain functions as a complex network of billions of interconnected neurons, coordinating processes from basic reflexes to high-level cognition. Dysfunction in these networks contribute to neurological and psychiatric disord…
View article: Medtronic Percept<sup>™</sup>Recorded LFP Pre-Processing to Remove Noise and Cardiac Signals From Neural Recordings
Medtronic Percept<sup>™</sup>Recorded LFP Pre-Processing to Remove Noise and Cardiac Signals From Neural Recordings Open
Chronic brain sensing devices, such as the Medtronic Percept™ or Neuropace RNS system, record local field potentials (LFPs) that may be vulnerable to noise from hardware limitations, environmental factors, movement, stimulation, cardiac si…
View article: Feature extraction and prediction of spinal cord stimulation evoked compound action potentials in humans
Feature extraction and prediction of spinal cord stimulation evoked compound action potentials in humans Open
Objective. Evoked compound action potentials (ECAPs) during spinal cord stimulation (SCS) may be useful in the treatment of chronic pain as a control signal for closed-loop neuromodulation. However, considerable inter-individual variabilit…
View article: Micromagnetic Stimulation (μMS) Controls Dopamine Release: An in vivo Study Using WINCS Harmoni
Micromagnetic Stimulation (μMS) Controls Dopamine Release: An in vivo Study Using WINCS Harmoni Open
Research into the role of neurotransmitters in regulating normal and pathologic brain functions has made significant progress. Yet, clinical trials that aim to improve therapeutic interventions do not take advantage of the in vivo changes …
View article: Thermal changes in guidewires used during endoscopic retrograde cholangiopancreatography during electrical conductance: Ex-vivo safety experiment
Thermal changes in guidewires used during endoscopic retrograde cholangiopancreatography during electrical conductance: Ex-vivo safety experiment Open
Risks of pancreaticobiliary tissue damage secondary to electrical conduction along cannulation wires in the vicinity of electrocautery have rarely been independently studied and remain mostly a theoretical issue. We aimed to evaluate heat …
View article: Anterior nucleus of thalamus deep brain stimulation for medication refractory epilepsy modulates theta and low-frequency gamma activity: a case study
Anterior nucleus of thalamus deep brain stimulation for medication refractory epilepsy modulates theta and low-frequency gamma activity: a case study Open
A 35-year-old gentleman with a traumatic brain injury was diagnosed with refractory epilepsy with electroencephalogram and imaging findings supporting a broad seizure onset pattern in bilateral frontotemporal regions. He therefore received…
View article: Portable Arbitrary Pulse Generator for Driving Microcoils for Micromagnetic Neurostimulation
Portable Arbitrary Pulse Generator for Driving Microcoils for Micromagnetic Neurostimulation Open
Micromagnetic stimulation (μMS) is a promising branch of neurostimulation but without some of the drawbacks of electrical stimulation. Microcoil (μcoil)-based magnetic stimulation uses small micrometer-sized coils that generate a time-vary…
View article: Impact of anesthesia on micromagnetic stimulation (μMS) of the vagus nerve
Impact of anesthesia on micromagnetic stimulation (μMS) of the vagus nerve Open
To treat diseases associated with vagal nerve control of peripheral organs, it is necessary to selectively activate efferent and afferent fibers in the vagus. As a result of the nerve’s complex anatomy, fiber-specific activation proves cha…
View article: Neural signal data collection and analysis of Percept™ PC BrainSense recordings for thalamic stimulation in epilepsy
Neural signal data collection and analysis of Percept™ PC BrainSense recordings for thalamic stimulation in epilepsy Open
Deep brain stimulation (DBS) using Medtronic’s Percept™ PC implantable pulse generator is FDA-approved for treating Parkinson’s disease (PD), essential tremor, dystonia, obsessive compulsive disorder, and epilepsy. Percept™ PC enables simu…
View article: Portable Arbitrary Pulse Generator for Driving μCoils for Micromagnetic Neurostimulation
Portable Arbitrary Pulse Generator for Driving μCoils for Micromagnetic Neurostimulation Open
Micromagnetic stimulation (μMS) is a promising branch of neurostimulation technologies. Microcoil (μcoil) based magnetic stimulation uses micrometer sized coils that generate a time-varying magnetic field which as per Faraday’s Laws of Ele…
View article: Micromagnetic Stimulation (μMS) Controls Dopamine Release: An<i>in vivo</i>Study Using WINCS<i>Harmoni</i>
Micromagnetic Stimulation (μMS) Controls Dopamine Release: An<i>in vivo</i>Study Using WINCS<i>Harmoni</i> Open
Objective Research into the role of neurotransmitters in regulating normal and pathologic brain functions has made significant progress. Yet, clinical trials that aim to improve therapeutic interventions do not take advantage of the in viv…
View article: Micromagnetic stimulation (µMS) dose-response of the rat sciatic nerve
Micromagnetic stimulation (µMS) dose-response of the rat sciatic nerve Open
Objective. The objective of this study was to investigate the effects of micromagnetic stimuli strength and frequency from the Mag netic Pen (MagPen) on the rat right sciatic nerve. The nerve’s response was measured by recording muscle act…
View article: Epidural stimulation restores muscle synergies by modulating neural drives in participants with sensorimotor complete spinal cord injuries
Epidural stimulation restores muscle synergies by modulating neural drives in participants with sensorimotor complete spinal cord injuries Open
View article: In silico development and validation of Bayesian methods for optimizing deep brain stimulation to enhance cognitive control
In silico development and validation of Bayesian methods for optimizing deep brain stimulation to enhance cognitive control Open
Objective. deep brain stimulation (DBS) of the ventral internal capsule/striatum (VCVS) is a potentially effective treatment for several mental health disorders when conventional therapeutics fail. Its effectiveness, however, depends on co…
View article: Effect of epidural spinal cord stimulation on female sexual function after spinal cord injury
Effect of epidural spinal cord stimulation on female sexual function after spinal cord injury Open
Sexual dysfunction is a common consequence for women with spinal cord injury (SCI); however, current treatments are ineffective, especially in the under-prioritized population of women with SCI. This case-series, a secondary analysis of th…
View article: Methods and system for recording human physiological signals from implantable leads during spinal cord stimulation
Methods and system for recording human physiological signals from implantable leads during spinal cord stimulation Open
Objectives This article presents a method–including hardware configuration, sampling rate, filtering settings, and other data analysis techniques–to measure evoked compound action potentials (ECAPs) during spinal cord stimulation (SCS) in …
View article: Bayesian methods for optimizing deep brain stimulation to enhance cognitive control
Bayesian methods for optimizing deep brain stimulation to enhance cognitive control Open
Objective Deep brain stimulation (DBS) of the ventral internal capsule/striatum (VCVS) is a potentially effective treatment for several mental health disorders when conventional therapeutics fail. Its effectiveness, however, depends on cor…
View article: Micromagnetic Stimulation (μMS) Dose-Response of the Rat Sciatic Nerve
Micromagnetic Stimulation (μMS) Dose-Response of the Rat Sciatic Nerve Open
Objective The objective of this study was to investigate the effects of micromagnetic stimuli strength and frequency from the Mag netic Pen (MagPen) on the rat right sciatic nerve. The nerve’s response would be measured by recording muscle…
View article: Reliability of visual review of intracranial electroencephalogram in identifying the seizure onset zone: A systematic review and implications for the accuracy of automated methods
Reliability of visual review of intracranial electroencephalogram in identifying the seizure onset zone: A systematic review and implications for the accuracy of automated methods Open
Visual review of intracranial electroencephalography (iEEG) is often an essential component for defining the zone of resection for epilepsy surgery. Unsupervised approaches using machine and deep learning are being employed to identify sei…
View article: Effect of epidural spinal cord stimulation after chronic spinal cord injury on volitional movement and cardiovascular function: study protocol for the phase II open label controlled E-STAND trial
Effect of epidural spinal cord stimulation after chronic spinal cord injury on volitional movement and cardiovascular function: study protocol for the phase II open label controlled E-STAND trial Open
Introduction Spinal cord injury (SCI) leads to significant changes in morbidity, mortality and quality of life (QOL). Currently, there are no effective therapies to restore function after chronic SCI. Preliminary studies have indicated tha…
View article: Epidural stimulation restores muscle synergies by modulating neural drives in participants with motor/sensory complete spinal cord injuries
Epidural stimulation restores muscle synergies by modulating neural drives in participants with motor/sensory complete spinal cord injuries Open
Multiple studies have corroborated restored volitional motor control after motor-complete spinal cord injury (SCI) through the use of spinal cord stimulation (SCS/eSCS) but rigorous quantitative descriptions have been lacking. Using a stru…
View article: The safety of epidural spinal cord stimulation to restore function after spinal cord injury: post-surgical complications and incidence of cardiovascular events
The safety of epidural spinal cord stimulation to restore function after spinal cord injury: post-surgical complications and incidence of cardiovascular events Open
View article: Evaluation of functional MRI-based human brain parcellation: a review
Evaluation of functional MRI-based human brain parcellation: a review Open
Brain parcellations play a crucial role in the analysis of brain imaging data sets, as they can significantly affect the outcome of the analysis. In recent years, several novel approaches for constructing MRI-based brain parcellations have…
View article: Perspectives on Understanding Aberrant Brain Networks in Epilepsy
Perspectives on Understanding Aberrant Brain Networks in Epilepsy Open
Epilepsy is a neurological disorder affecting approximately 70 million people worldwide. It is characterized by seizures that are complex aberrant dynamical events typically treated with drugs and surgery. Unfortunately, not all patients b…