Théodore Decaix
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View article: Driving knowledge assessment in cognitively impaired older adults: evidence from geriatric day hospitals
Driving knowledge assessment in cognitively impaired older adults: evidence from geriatric day hospitals Open
Our study has raised concerns regarding the overall poor theoretical driving skills in older drivers and their low self-evaluation ability. The MoCA and the DSTT may be useful for guiding driving discontinuation in cognitively impaired old…
View article: Benefits of physical activity on cognitive function in patients with neurocognitive disorders: A systematic review
Benefits of physical activity on cognitive function in patients with neurocognitive disorders: A systematic review Open
Neurocognitive disorders, particularly in older adults, significantly affect functional abilities and global health. Physical activity has emerged as a potential non-pharmacological intervention to improve cognitive performance in patients…
View article: Dual risk of anticholinergic burden and CSF alzheimer’s biomarkers in older patients: a mortality follow-up study from daily medical practice
Dual risk of anticholinergic burden and CSF alzheimer’s biomarkers in older patients: a mortality follow-up study from daily medical practice Open
Anticholinergic burden may increase vulnerability to mortality in older adults with an AD biomarker profile. These results support integrating pharmacological and biological risk factors into personalized dementia care.
View article: Lipidomic analysis of MDCK-parental cells and MDCK-MDR1 cells exposed to GF120918 and clarithromycin highlights the role of P-glycoprotein in sphingolipid transport
Lipidomic analysis of MDCK-parental cells and MDCK-MDR1 cells exposed to GF120918 and clarithromycin highlights the role of P-glycoprotein in sphingolipid transport Open
P-glycoprotein (P-gp) is one of the most studied drug transporters, as it enables the cellular efflux of 50 % of marketed drugs and plays a key role in many drug-drug interactions. While a high number of studies has investigated the use of…
View article: Unraveling Homocysteine's Role in Dementia: No Specific Association with Alzheimer's Disease, but a Connection to White Matter Hyperintensities
Unraveling Homocysteine's Role in Dementia: No Specific Association with Alzheimer's Disease, but a Connection to White Matter Hyperintensities Open
Hyperhomocysteinemia (HHcy) is an established risk factor for cognitive impairment. The specific role of HHcy in the pathophysiology of Alzheimer's disease (AD) is debated, as most of the suspected mechanisms overlap with those of vascular…
Usefulness of Cerebrospinal Fluid Alzheimer's disease biomarkers in older patients: Evidence from a national multicenter prospective study Open
CSF AD biomarkers added substantial value to clinical assessment in patients over 80. Their use seems crucial in the diagnostic process for older adults referred to memory clinics.
View article: Pharmacokinetics and pharmacodynamics of drug‒drug interactions in hospitalized older adults treated with direct oral anticoagulants
Pharmacokinetics and pharmacodynamics of drug‒drug interactions in hospitalized older adults treated with direct oral anticoagulants Open
Purpose Polypharmacy is a frequent situation in older adults that increases the risk of drug-drug interactions (DDIs), both pharmacokinetic (PK) and pharmacodynamic (PD). Direct oral anticoagulants (DOACs) are frequently prescribed in olde…
View article: Pharmacokinetics and pharmacodynamics of drug‒drug interactions in hospitalized older adults treated with direct oral anticoagulants
Pharmacokinetics and pharmacodynamics of drug‒drug interactions in hospitalized older adults treated with direct oral anticoagulants Open
Purpose: Polypharmacy is a frequent situation in older adults that increases the risk of DDIs, both PK and PD. DOACs are frequently prescribed in older adults, mainly because of the high prevalence of atrial fibrillation (AF). DOACs are su…
View article: Plasma lipidomic analysis to investigate putative biomarkers of P‐glycoprotein activity in healthy volunteers
Plasma lipidomic analysis to investigate putative biomarkers of P‐glycoprotein activity in healthy volunteers Open
P‐glycoprotein (P‐gp) is an efflux transporter involved in the bioavailability of many drugs currently on the market. P‐gp is responsible for several drug–drug interactions encountered in clinical practice leading to iatrogenic hospital ad…