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Dose Considerations for Vaccinia Oncolytic Virus Based on Retrospective Reanalysis of Early and Late Clinical Trials Open

Mefotse Saha Cyrelle Ornella, Jae-Joon Kim, Euna Cho, Mong Cho, Tae-Ho Hwang · 2024

Medicine Biology

Over the past decade, oncolytic viruses (OVs) have been developed as a promising treatment alone or in combination in immuno-oncology but have faced challenges in late-stage clinical trials. Our retrospective reanalysis of vaccinia oncolyt…

Web-based Non-contact Edge Computing Solution for Suspected COVID-19 Infection Classification Model Open

Tae-Ho Hwang, Kang Yoon Lee · 2023

Computer science

The recent outbreak of the COVID-19 coronavirus pandemic has necessitated the development of web-based, non-contact edge analytics solutions. Non-contact sensors serve as the interface between web servers and edge analytics through web eng…

Association of 5α-Reductase Inhibitor Prescription With Bladder Cancer Progression in Males in South Korea Open

Min Ho An, Min Seo Kim, Chungsoo Kim, Tae Il Noh, Kwan Joong Joo , et al. · 2023

Medicine

Importance The antiandrogenic effect of the 5α-reductase inhibitor (5-ARI) has been investigated for its role in preventing male-predominant cancers. Although 5-ARI has been widely associated with prostate cancer, its association with urot…

Immunotherapy for Peritoneal Carcinomatosis: Challenges and Prospective Outcomes Open

Mefotse Saha Cyrelle Ornella, Narayanasamy Badrinath, Kyeong-Ae Kim, Jung Hee Kim, Euna Cho , et al. · 2023

Medicine

Peritoneal metastasis, also known as peritoneal carcinomatosis (PC), is a refractory cancer that is typically resistant to conventional therapies. The typical treatment for PC is a combination of cytoreductive surgery (CRS) and hyperthermi…

Supplementary Methods from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology

Supplementary Methods PDF file - 44K, GLP toxicology study, In vivo imaging and mouse immunohistochemical analyses

Data from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology

Efforts to selectively target and disrupt established tumor vasculature have largely failed to date. We hypothesized that a vaccinia virus engineered to target cells with activation of the ras/MAPK signaling pathway (JX-594) could specific…

Supplementary Figure 2 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology Chemistry

Supplementary Figure 2 PDF file - 144K, Bevacizumab reduces TK1 levels & blocks VEGF-mediated JX-594 sensitization in HUVECs, demonstrated by decreased transgene expression (GFP) and decreased burst size

Supplementary Figure 1 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology Medicine

Supplementary Figure 1 PDF file - 74K, VEGF- and FGF-2 stimulate vaccinia replication

Supplementary Table 1 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology Medicine Computer science

Supplementary Table 1 PDF file - 30K, Rabbit GLP toxicology study of intravenous JX-594

Supplementary Video 1 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology Medicine

Supplementary Video 1 MPG file - 708K, 3-dimensional tumor model of 10 cm HCC tumor depicted in Fig. 4a (baseline; prior to JX-594 treatment). Beige = perfused; green = hypoperfused; red = necrotic

Supplementary Video 2 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Medicine Biology

Supplementary Video 2 MPG file - 1158K, 3-dimensional tumor model of 10 cm HCC tumor depicted in Fig. 4b (baseline; 5 days post JX-594 treatment). Beige = perfused; green = hypoperfused; red = necrotic

Supplementary Figure 4 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology

Supplementary Figure 4 PDF file - 69K, Day 5 enhancement waterfall plot

Supplementary Figure 3 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology

Supplementary Figure 3 PDF file - 83K, Normal fibroblasts (GM38 cells) do not express VEGFR2 and are not sensitized to JX-594 infection upon incubation with VEGF

Supplementary Video 1 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Medicine Biology

Supplementary Video 1 MPG file - 708K, 3-dimensional tumor model of 10 cm HCC tumor depicted in Fig. 4a (baseline; prior to JX-594 treatment). Beige = perfused; green = hypoperfused; red = necrotic

Supplementary Video 2 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology

Supplementary Video 2 MPG file - 1158K, 3-dimensional tumor model of 10 cm HCC tumor depicted in Fig. 4b (baseline; 5 days post JX-594 treatment). Beige = perfused; green = hypoperfused; red = necrotic

Supplementary Methods from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology

Supplementary Methods PDF file - 44K, GLP toxicology study, In vivo imaging and mouse immunohistochemical analyses

Supplementary Figure 4 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology

Supplementary Figure 4 PDF file - 69K, Day 5 enhancement waterfall plot

Supplementary Figure 2 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology

Supplementary Figure 2 PDF file - 144K, Bevacizumab reduces TK1 levels & blocks VEGF-mediated JX-594 sensitization in HUVECs, demonstrated by decreased transgene expression (GFP) and decreased burst size

Data from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology Medicine

Efforts to selectively target and disrupt established tumor vasculature have largely failed to date. We hypothesized that a vaccinia virus engineered to target cells with activation of the ras/MAPK signaling pathway (JX-594) could specific…

Supplementary Table 1 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology Computer science

Supplementary Table 1 PDF file - 30K, Rabbit GLP toxicology study of intravenous JX-594

Supplementary Figure 1 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology Medicine

Supplementary Figure 1 PDF file - 74K, VEGF- and FGF-2 stimulate vaccinia replication

Supplementary Figure 3 from Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans Open

Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard B. Patt , et al. · 2023

Biology Medicine

Supplementary Figure 3 PDF file - 83K, Normal fibroblasts (GM38 cells) do not express VEGFR2 and are not sensitized to JX-594 infection upon incubation with VEGF

Enhancing Privacy-Preserving Personal Identification Through Federated Learning With Multimodal Vital Signs Data Open

Tae-Ho Hwang, Jingyao Shi, Kang Yoon Lee · 2023

Computer science Mathematics Biology

Personal identification (PI) can be verified using multimodal vital sign measurement methodologies in human physiology, such as electrocardiography (ECG) and radar signals. However, these processes are inevitably associated with concerns o…

Use of combined treatment of 3rd-generation cephalosporin, azithromycin and antiviral agents on moderate SARs-CoV-2 patients in South Korea: A retrospective cohort study Open

Wooyoung Hong, Yukyung Park, Bong-Ok Kim, Sung Kyu Park, Jiin Shin , et al. · 2022

Medicine Biology

Objectives To assess efficacy and safety of the combined treatment of antibiotics (3rd-generation cephalosporin and azithromycin) and antiviral agents (lopinavir/ritonavir or hydroxychloroquine) on moderate COVID-19 patients in South Korea…

Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis Open

Min Seo Kim, Min Ho An, Won Jun Kim, Tae-Ho Hwang · 2020

Medicine Political science

Background Numerous clinical trials and observational studies have investigated various pharmacological agents as potential treatment for Coronavirus Disease 2019 (COVID-19), but the results are heterogeneous and sometimes even contradicto…

Engineering and Preclinical Evaluation of Western Reserve Oncolytic Vaccinia Virus Expressing A167Y Mutant Herpes Simplex Virus Thymidine Kinase Open

S M Bakhtiar Ul Islam, Young Mi Hong, Mefotse Saha Cyrelle Ornella, Daniel Ngabire, Hyun‐Jung Jang , et al. · 2020

Biology

Viral replication of thymidine kinase deleted (tk−) vaccinia virus (VV) is attenuated in resting normal cells, enabling cancer selectivity, however, replication potency of VV-tk− appears to be diminished in cancer cells. Previously, we fou…

Treatment Response to Hydroxychloroquine and Antibiotics for mild to moderate COVID-19: a retrospective cohort study from South Korea Open

Min Ho An, Min Seo Kim, Yu-Kyung Park, Bong-Ok Kim, Seok Ho Kang , et al. · 2020

Medicine

Objectives To assess the efficacy of hydroxychloroquine on mild-moderate COVID-19 patients in South Korea. Methods A retrospective cohort study of the 358 laboratory-confirmed SARS-CoV-2 (COVID-19) patients was conducted. 226 patients met …

Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: A systematic review and network meta-analysis of confounder-adjusted 20212 hospitalized patients Open

Min Seo Kim, Min Ho An, Won Jun Kim, Tae-Ho Hwang · 2020

Medicine Political science

Objective To evaluate the comparative efficacy and safety of pharmacological interventions used in treating COVID-19 and form a basis for an evidence-based guideline of COVID-19 management by evaluating the level of evidence behind each tr…

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