Explanipedia

A Reference Atlas of the Human Dorsal Root Ganglion Open

Shamsuddin A. Bhuiyan, Saad S. Nagi, Ishwarya Sankaranarayanan, Evangelia Semizoglou, Dmitry Usoskin , et al. · 2025

Somatosensory perception largely emerges from diverse peripheral sensory neurons whose cell bodies reside in dorsal root ganglia (DRG). Damage or dysfunction of DRG neurons is a major cause of chronic pain and sensory loss. In mice, deep s…

113 Targeting MRGPRX2: A Transformative Approach to Inflammatory Skin Conditions Open

Sreya Bagchi, Amanda Jacobson, Alisa Pavel, Keerthana Natarajan, Ishwarya Sankaranarayanan , et al. · 2025

A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences Open

Katherin Gabriel, Olivia Davis, Seph M. Palomino, Satoshi Ishishita, Helen Poldsam , et al. · 2025

The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-motor integration, and a processing site f…

Molecular and functional asymmetry in Cckar-expressing vagal sensory neurons Open

Hailey F. Welch, Ishwarya Sankaranarayanan, Veronica M. Hong, Haniya Qavi, Khadijah Mazhar , et al. · 2025

The vagus nerves are important carriers of sensory information from the viscera to the brain. Emerging evidence suggests that sensory signaling through the right, but not the left, vagus nerve evokes striatal dopamine release and reinforce…

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion Open

Ole A. Ahlgreen, Mads W. Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi , et al. · 2025

Satellite glial cells (SGCs) enclose sensory neuron somata and initial axon segments in the dorsal root ganglia (DRG) and play a critical role in regulating the neuronal microenvironment. While DRG neuron diversity is well established, SGC…

Single-cell sequencing uncovers sensory neuron–mediated CGRP signaling as a driver of sarcoma progression Open

Sowmya Ramesh, Qizhi Qin, Zhao Li, Masnsen Cherief, Lingke Zhong , et al. · 2025

Bone pain is a presenting feature of bone cancers such as osteosarcoma (OS), relayed by skeletal-innervating peripheral afferent neurons. Potential functions of tumor-associated sensory neurons in bone cancers beyond pain sensation are unk…

Detection of probable neuronal gene expression changes in skin biopsies from patients with paclitaxel-induced peripheral neuropathy Open

Andi Wangzhou, Surendra Dasari, Diana Tavares‐Ferreira, Sybil C. L. Hrstka, Sandra Rieger , et al. · 2025

Our inability to obtain nerve samples from the vast majority of neuropathic pain patients impedes our ability to understand the disease, creates challenges in understanding mechanisms in specific patient populations, and limits our ability…

The cell-type-specific genetic architecture of chronic pain in brain and dorsal root ganglia Open

Sylvanus Toikumo, Marc Parisien, Michael J. Leone, Chaitanya Srinivasan, Huasheng Yu , et al. · 2025

Chronic pain is a complex clinical problem comprising multiple conditions that may share a common genetic profile. Genome-wide association studies (GWAS) have identified many risk loci whose cell-type context remains unclear. Here, we inte…

Erratum to “Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells”. [Mucosal Immunol. 18(5) (2025) 1199–1217] Open

Samuel Álvarez-Arguedas, Khadijah Mazhar, Andi Wangzhou, Ishwarya Sankaranarayanan, Gabriela Gaona , et al. · 2025

Peripheral nerve-targeting and pain-promoting transcriptomic signatures in early Guillain-Barré syndrome Open

J A O'Brien, Joseph B. Lesnak, Ishwarya Sankaranarayanan, Asta Arendt-Tranholm, Nikhil Nageshwar Inturi , et al. · 2025

Guillain-Barré syndrome (GBS) is an autoimmune disorder that causes weakness, sensory loss, autonomic dysfunction, and chronic neuropathic pain. The mediators responsible for driving early autoimmune injury in the most common GBS variant, …

Enabling wider access to human molecular neuroscience research in pain: A simple preservation method for human dorsal root ganglion neurons in Hibernate A media Open

Joseph B. Lesnak, Mandee K. Schaub, Kimberly Gómez, Alicia Rivera, Santiago Loya‐López , et al. · 2025

Summary The use of human dorsal root ganglion (DRG) from organ donors opens the door for research into the molecular biology and physiology of human nociceptors; however, there are barriers to working with this tissue including logistical …

Type I IFNs enhance human dorsal root ganglion nociceptor excitability and induce TRPV1 sensitization Open

Úrzula Franco‐Enzástiga, Keerthana Natarajan, Felipe Espinosa, Rafael Granja-Vazquez, Hemanth Mydugolam , et al. · 2025

Type I interferons (IFNs) are critical cytokines for antiviral defense and are linked to painful diseases like rheumatoid arthritis, lupus, and neuropathic pain in humans. IFN-α therapy can cause myalgia, headache, and joint and abdominal …

Identification of sensory fiber types in mouse temporomandibular joint tissues Open

J Alfaro, E. Wang, Kyle M. Allen, Alejandro J. Almarza, Benjamin R. Arenkiel , et al. · 2025

Temporomandibular joint (TMJ) disorders (TMJDs) are linked to heightened nerve sensitivity in TMJ tissues. To set the groundwork for investigating the mechanisms governing this increased responsiveness, this study aimed to identify the typ…

Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy Open

Diana Tavares‐Ferreira, Breanna Q. Shen, Juliet M. Mwirigi, Stephanie Shiers, Ishwarya Sankaranarayanan , et al. · 2025

Diabetic peripheral neuropathy (DPN) is a prevalent complication of diabetes mellitus caused by metabolic toxicity to peripheral axons. We aimed to gain deep mechanistic insight into the disease using transcriptomics on tibial and sural ne…

Editorial commitment to trust and integrity in science: implications for pain and anesthesiology research Open

Tonya M. Palermo, Didier Bouhassira, Karen D. Davis, Hugh C. Hemmings, Robert W. Hurley , et al. · 2025

International audience

Editorial commitment to trust and integrity in science: implications for pain and anesthesiology research. Open

Tonya M. Palermo, Didier Bouhassira, Karen D. Davis, Hugh C. Hemmings, Robert W. Hurley , et al. · 2025

Cross-platform transcriptomic data integration identifies an overactive neuro-immune signature in human osteoarthritis synovium Open

Michael D. Newton, Hannah Swahn, Dana E. Orange, Joseph B. Lesnak, Theodore J. Price , et al. · 2025

End-stage OA synovium is markedly enriched for neuroinflammatory and neuro-immune signaling, putatively governed by STAT1, FLI1, and VDR.

Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells Open

Samuel Álvarez-Arguedas, Khadijah Mazhar, Andi Wangzhou, Ishwarya Sankaranarayanan, Gabriela Gaona , et al. · 2025

Editorial commitment to trust and integrity in science Open

Tonya M. Palermo, Didier Bouhassira, Karen D. Davis, Hugh C. Hemmings, Robert W. Hurley , et al. · 2025

Sensory neuron–expressed FGF13 controls nociceptive signaling in diabetic neuropathy models Open

A.K. Singh, Matteo Bernabucci, Nolan M. Dvorak, Zahra Haghighijoo, Jessica Di Re , et al. · 2025

Nociception involves complex signaling, yet intrinsic mechanisms bidirectionally regulating this process remain unexplored. Here, we show that the fibroblast growth factor 13 (FGF13)/Nav1.7 protein-protein interaction (PPI) complex bidirec…

Editorial Commitment to Trust and Integrity in Science: Implications for Pain and Anesthesiology Research Open

Tonya M. Palermo, Didier Bouhassira, Karen D. Davis, Hugh C. Hemmings, Robert W. Hurley , et al. · 2025

International audience

Editorial commitment to trust and integrity in science: Implications for pain and anesthesiology research Open

Tonya M. Palermo, Didier Bouhassira, Karen D. Davis, Hugh C. Hemmings, Robert W. Hurley , et al. · 2025

Etiological basis for chronic pain genetic variation in brain and dorsal root ganglia cell types Open