Richard Lee
YOU?
Author Swipe
View article: Activated GDF11/8 subforms predict cardiovascular events and mortality in humans
Activated GDF11/8 subforms predict cardiovascular events and mortality in humans Open
Circulating Growth Differentiation Factors 11 and 8 (GDF11/8) exist in both latent and active forms, and it is unclear if specific forms can predict disease outcomes. Our data suggest that a dual-specific aptamer selectively binds GDF11/8 …
View article: Brain tumor segmentation using deep learning: high performance with minimized MRI data
Brain tumor segmentation using deep learning: high performance with minimized MRI data Open
Purpose Brain tumor segmentation with MRI is a challenging task, traditionally relying on manual delineation of regions-of-interest across multiple imaging sequences. However, this data-intensive approach is time-consuming. We aimed to opt…
View article: Covalent binding of thioredoxin to TXNIP is required for diet-induced insulin resistance in the liver
Covalent binding of thioredoxin to TXNIP is required for diet-induced insulin resistance in the liver Open
Hepatic insulin resistance is an important pathophysiology in type 2 diabetes, and the mechanisms by which high-caloric diets induce insulin resistance are unclear. Among vertebrate animals, mammals have retained a unique molecular change …
View article: Physiologically informed predictability of a teammate’s future actions forecasts team performance
Physiologically informed predictability of a teammate’s future actions forecasts team performance Open
In collaborative environments, a deep understanding of multi-human teaming dynamics is essential for optimizing performance. However, the relationship between individuals' behavioral and physiological markers and their combined influence o…
View article: <i>In Situ</i> Graphene-Seq: Spatial Transcriptomics and Chronic Electrophysiological Characterization of Tissue Microenvironments
<i>In Situ</i> Graphene-Seq: Spatial Transcriptomics and Chronic Electrophysiological Characterization of Tissue Microenvironments Open
Biological systems are composed of diverse, interconnected cell types, yet capturing both their functional dynamics and molecular identities at high spatiotemporal resolution remains challenging. While electrophysiological measurements pro…
View article: LepR-mesenchymal stem cells represent the main target of the nociceptive CGRP pathway in white adipose tissue browning
LepR-mesenchymal stem cells represent the main target of the nociceptive CGRP pathway in white adipose tissue browning Open
Sympathetic innervation regulates white adipose tissue (WAT) browning; however, the roles of nociceptive neurons and their associated target cells remain unknown. Here, we used single-nucleus RNA-sequencing to identify leptin receptor (Lep…
View article: Study of angle of arrival estimation with linear arrays of simulated Rydberg atom receivers
Study of angle of arrival estimation with linear arrays of simulated Rydberg atom receivers Open
Rydberg atom receivers have the potential to supplement or replace traditional sensing technologies due to the theoretically high sensitivity, electrically small packaging, and unconventional field detection mechanisms they can provide. Gi…
View article: Physiologically-Informed Predictability of a Teammate's Future Actions Forecasts Team Performance
Physiologically-Informed Predictability of a Teammate's Future Actions Forecasts Team Performance Open
In collaborative environments, a deep understanding of multi-human teaming dynamics is essential for optimizing performance. However, the relationship between individuals' behavioral and physiological markers and their combined influence o…
View article: Do Environmental Laws Matter for Corporate Ethics and Green Process Innovation in Environment Performance? The Moderating Role of Institutional Support
Do Environmental Laws Matter for Corporate Ethics and Green Process Innovation in Environment Performance? The Moderating Role of Institutional Support Open
Drawing on institutional theory, this study disentangles the intricate relationships between environmental laws, corporate environmental ethics (CEE), green process innovation (GPI), and environmental performance. Using survey data from ma…
View article: An AI-Cyborg System for Adaptive Intelligent Modulation of Organoid Maturation
An AI-Cyborg System for Adaptive Intelligent Modulation of Organoid Maturation Open
Recent advancements in flexible bioelectronics have enabled continuous, long-term stable interrogation and intervention of biological systems. However, effectively utilizing the interrogated data to modulate biological systems to achieve s…
View article: Study of Angle of Arrival Estimation with Linear Arrays of Simulated Rydberg Atom Receivers
Study of Angle of Arrival Estimation with Linear Arrays of Simulated Rydberg Atom Receivers Open
Rydberg atom receivers have the potential to supplement or replace traditional sensing technologies due to the high sensitivity, electrically small packaging, and unconventional field detection mechanisms they can provide. Given the import…
View article: Considering best practice standards for routine whole-genome sequencing for TB care and control
Considering best practice standards for routine whole-genome sequencing for TB care and control Open
TB is a priority pathogen for the application of whole-genome sequencing (WGS) into routine public health practice. In low-incidence settings, a growing number of services have begun to incorporate routine WGS into standard practice. The i…
View article: P53 Activation Promotes Maturational Characteristics of Pluripotent Stem Cell‐Derived Cardiomyocytes in 3‐Dimensional Suspension Culture Via FOXO‐FOXM1 Regulation
P53 Activation Promotes Maturational Characteristics of Pluripotent Stem Cell‐Derived Cardiomyocytes in 3‐Dimensional Suspension Culture Via FOXO‐FOXM1 Regulation Open
Background Current protocols generate highly pure human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs) in vitro that recapitulate characteristics of mature in vivo cardiomyocytes. Yet, a risk of arrhythmias exists when hi…
View article: Study of Angle of Arrival Estimation with Linear Arrays of Simulated Rydberg Atom Receivers
Study of Angle of Arrival Estimation with Linear Arrays of Simulated Rydberg Atom Receivers Open
Rydberg atom receivers have the potential to supplement or replace traditional sensing technologies due to the high sensitivity, electrically small packaging, and unconventional field detection mechanisms they can provide. Given the import…
View article: Genetic analysis and multimodal imaging identify novel mtDNA 12148T>C leading to multisystem dysfunction with tissue-specific heteroplasmy
Genetic analysis and multimodal imaging identify novel mtDNA 12148T>C leading to multisystem dysfunction with tissue-specific heteroplasmy Open
Patients with mitochondrial disorders present with clinically diverse symptoms, largely driven by heterogeneous mutations in mitochondrial-encoded and nuclear-encoded mitochondrial genes. These mutations ultimately lead to complex biochemi…
View article: GDF11 and aging biology - controversies resolved and pending
GDF11 and aging biology - controversies resolved and pending Open
Since the exogenous administration of GDF11, a TGF-ß superfamily member, was reported to have beneficial effects in some models of human disease, there have been many research studies in GDF11 biology. However, many studies have now confir…
View article: Discovery adductomics provides a comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans
Discovery adductomics provides a comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans Open
DNA damage causes genomic instability underlying many diseases, with traditional analytical approaches providing minimal insight into the spectrum of DNA lesions in vivo. Here we used untargeted chromatography-coupled tandem mass spectrome…
View article: Study of Angle of Arrival Estimation with Linear Arrays of Simulated Rydberg Atom Receivers
Study of Angle of Arrival Estimation with Linear Arrays of Simulated Rydberg Atom Receivers Open
Rydberg atom receivers have the potential to supple- ment or replace traditional sensing technologies due to the high sensitivity, unconventional detection mechanisms, and unusual responses they can provide. Given the importance of angle o…
View article: Study of Angle of Arrival Estimation with Linear Arrays of Simulated Rydberg Atom Receivers
Study of Angle of Arrival Estimation with Linear Arrays of Simulated Rydberg Atom Receivers Open
Rydberg atom receivers have the potential to supple- ment or replace traditional sensing technologies due to the high sensitivity, unconventional detection mechanisms, and unusual responses they can provide. Given the importance of angle o…
View article: OC 62.1 Differential Suppression of Arterial Versus Venous Thrombosis but Preserved Hemostasis in Mice Expressing Fibrinogen that Cannot Support Fibrin Formation
OC 62.1 Differential Suppression of Arterial Versus Venous Thrombosis but Preserved Hemostasis in Mice Expressing Fibrinogen that Cannot Support Fibrin Formation Open
Background: Elevated circulating fibrinogen correlates with increased risk for both cardiovascular and venous thromboembolic diseases.In vitro studies show that formation of a highly dense fibrin matrix is a major determinant of clot struc…
View article: A<i>Grim</i>link: the association between subclinical atherosclerosis and epigenetic age
A<i>Grim</i>link: the association between subclinical atherosclerosis and epigenetic age Open
[Figure: see text]
View article: Improving Quality of Life During Chemotherapy: Cannabinoids, Cryotherapy, and Scalp Cooling
Improving Quality of Life During Chemotherapy: Cannabinoids, Cryotherapy, and Scalp Cooling Open
There have been significant advances in the treatment of cancer in the past decade. However, patients continue to suffer from significant side effects of antineoplastic agents that greatly affect their quality of life (QOL), including chem…
View article: GDF-11 as a Potential Cardiac Pro-Angiogenic Factor
GDF-11 as a Potential Cardiac Pro-Angiogenic Factor Open
[Figure: see text]
View article: Deep Representation Learning of Tissue Metabolome and Computed Tomography Images Annotates Non-invasive Classification and Prognosis Prediction of NSCLC
Deep Representation Learning of Tissue Metabolome and Computed Tomography Images Annotates Non-invasive Classification and Prognosis Prediction of NSCLC Open
The rich chemical information from tissue metabolomics provides a powerful means to elaborate tissue physiology or tumor characteristics at cellular and tumor microenvironment levels. However, the process of obtaining such information requ…