Théophile Dimo
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View article: Safety assessment of Detarium microcarpum Guil. & Perr. (Leguminosae) root bark extract in rats: Acute, sub-acute toxicity, ADMET, molecular docking, and molecular dynamics simulations approach
Safety assessment of Detarium microcarpum Guil. & Perr. (Leguminosae) root bark extract in rats: Acute, sub-acute toxicity, ADMET, molecular docking, and molecular dynamics simulations approach Open
Since the last decades, Detarium microcarpum have been used and studied due to the significant properties to threat various ailments. It is therefore crucial to ascertain the safety properties of is phytoconstituents. The present study was…
View article: <i>Dichrocephala integrifolia</i> (L.f.) Kuntze Leaf Aqueous Extract Improves Liver Architecture in a Model of Aflatoxin‐Containing Peanut‐Induced Hepatotoxicity in Wistar Rats
<i>Dichrocephala integrifolia</i> (L.f.) Kuntze Leaf Aqueous Extract Improves Liver Architecture in a Model of Aflatoxin‐Containing Peanut‐Induced Hepatotoxicity in Wistar Rats Open
Consumption of aflatoxin‐contaminated food is responsible for hepatotoxicity. Dichrocephala integrifolia ( D. integrifolia ) is used in traditional African medicine to treat various liver diseases. This study aimed to evaluate the therapeu…
View article: Antiamnesic and Neurotrophic Effects of <i>Parkia biglobosa</i> (Jacq.) R. Br (Fabaceae) Aqueous Extract on In Vivo and In Vitro Models of Excitotoxicity
Antiamnesic and Neurotrophic Effects of <i>Parkia biglobosa</i> (Jacq.) R. Br (Fabaceae) Aqueous Extract on In Vivo and In Vitro Models of Excitotoxicity Open
Amnesia is a memory disorder marked by the inability to recall or acquire information. Hence, drugs that also target the neurogenesis process constitute a hope to discover a cure against memory disorders. This study is aimed at evaluating …
View article: Potential of Khaya senegalensis to mitigate epileptogenesis and cognitive dysfunction on kainate-induced post-status epilepticus model
Potential of Khaya senegalensis to mitigate epileptogenesis and cognitive dysfunction on kainate-induced post-status epilepticus model Open
These findings thus suggest that the extract is endowed with antiepileptogenic- and learning and memory-enhancing-like effects. These effects are likely mediated by anti-inflammatory and neurotrophic pathways. This justifies, therefore, it…
View article: Aqueous extract of Alstonia boonei De Wild (Apocynaceae) alleviates bone metabolism disorders induced by oxidised palm oil and sucrose supplementation in rats
Aqueous extract of Alstonia boonei De Wild (Apocynaceae) alleviates bone metabolism disorders induced by oxidised palm oil and sucrose supplementation in rats Open
Background: Poor nutritional status disrupts bone metabolism leading to fractures. This study investigated the effect of the aqueous leaf extract of Alstonia boonei on fractured rats fed a diet supplemented with oxidised palm oil and sucro…
View article: <i>Combretum aculeatum </i>Vent (Combretaceae) hydroethanolic root bark extract attenuates D-galactoseinduced cognitive impairment, oxidative, and hippocampi dysfunction in mice
<i>Combretum aculeatum </i>Vent (Combretaceae) hydroethanolic root bark extract attenuates D-galactoseinduced cognitive impairment, oxidative, and hippocampi dysfunction in mice Open
Introduction: Combretum aculeatum is a plant of Combretaceae family. In traditional medicine, it is used to treat schizophrenia. The aim of this study was to assess the possible impacts of hydroethanolic extract of C. aculeatum root bark o…
View article: Investigation of the phytochemical composition and anti-inflammatory properties of Afzelia africana leaves
Investigation of the phytochemical composition and anti-inflammatory properties of Afzelia africana leaves Open
Introduction: Afzelia africana is a large tree that is widespread in West Africa. Its bark is used in traditional medicine to treat rheumatism, edema, and pain. In our previous researches, we studied the phytochemical characteristics of th…
View article: Complete Freund’s adjuvant-induced arthritis in rats: Anti-inflammatory and antioxidant properties of <i>Allanblackia gabonensis</i> (guttiferae) aqueous extract
Complete Freund’s adjuvant-induced arthritis in rats: Anti-inflammatory and antioxidant properties of <i>Allanblackia gabonensis</i> (guttiferae) aqueous extract Open
Objectives: Allanblackia gabonensis (Guttiferae) stem bark extract is generally used in Cameroonian traditional medicine for its beneficial activities as antibiotics, anti-inflammatory, and antinociceptive. However, the claimed chronic ant…
View article: Kalanchoe pinnata aqueous extract efficacy against myocardial infarction and effects on three cardio-metabolic biomarkers in NaCl-overloaded rat
Kalanchoe pinnata aqueous extract efficacy against myocardial infarction and effects on three cardio-metabolic biomarkers in NaCl-overloaded rat Open
Cardiovascular diseases are among the causes of global mortality in the world with hypertension and myocardial infarction being one of the key risk factors. Kalanchoe pinnata is a plant that has shown antihypertensive and cardioprotective …
View article: Hepatoprotective and in vivo antioxidant effects of granulometric classes and decoction of <i>Ficus dicranostyla</i> Mildbread leaves powders against carbon tetrachloride‐induced hepatotoxicity in Wistar rats
Hepatoprotective and in vivo antioxidant effects of granulometric classes and decoction of <i>Ficus dicranostyla</i> Mildbread leaves powders against carbon tetrachloride‐induced hepatotoxicity in Wistar rats Open
Ficus dicranostyla is a plant from the Moraceae family commonly used in African countries for its nutritional value and its believed medicinal properties. Its antioxidant in vitro capacity and its richness in phenolic compounds have been p…
View article: The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction
The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction Open
Diabetes-associated cognitive dysfunction is linked to chronic hyperglycemia, oxidative stress, inflammation, cholinergic dysfunction, and neuronal degeneration. We investigated the antidiabetic and neuroprotective activity of a mixture of…
View article: Hepatoprotective effects of <i>Allanblackia gabonensis</i> aqueous trunk bark extract on carbon tetrachloride-induced chronic liver damage in Wistar rats
Hepatoprotective effects of <i>Allanblackia gabonensis</i> aqueous trunk bark extract on carbon tetrachloride-induced chronic liver damage in Wistar rats Open
Objectives: Natural bioactive compounds protect against oxidative stress-induced diseases. Studies have demonstrated antioxidant properties of Allanblackia gabonensis (member of Clusiaceae family), which is used for liver diseases. This wo…
View article: Aphrodisiac potentials of the aqueous extract of Hibiscus asper Hook. f. leaves (Malvaceae) in male Wistar rats
Aphrodisiac potentials of the aqueous extract of Hibiscus asper Hook. f. leaves (Malvaceae) in male Wistar rats Open
Introduction: In general medicine, male sexual dysfunction is a major source of worry and consultation. Finding alternative substances like plants to regulate these disturbances is motivated by the side effects of standard aphrodisiac medi…
View article: Treatment with <i>Markhamia tomentosa</i> Benth. K. Schum prevents carbon tetrachloride-induced liver damage in rats
Treatment with <i>Markhamia tomentosa</i> Benth. K. Schum prevents carbon tetrachloride-induced liver damage in rats Open
Objective: Markhamia tomentosa (Bignoniaceae) is a medicinal plant with several pharmacological properties. However, its hepatoprotective effects have been little studied. The aim of this study was to evaluate the protective effects of the…
View article: The Aqueous Extract of <i>Sclerocarya birrea</i>, <i>Nauclea latifolia</i>, and <i>Piper longum</i> Mixture Protects Striatal Neurons and Movement‐Associated Functionalities in a Rat Model of Diabetes‐Induced Locomotion Dysfunction
The Aqueous Extract of <i>Sclerocarya birrea</i>, <i>Nauclea latifolia</i>, and <i>Piper longum</i> Mixture Protects Striatal Neurons and Movement‐Associated Functionalities in a Rat Model of Diabetes‐Induced Locomotion Dysfunction Open
Among the many complications of type 2 diabetes (T2D), locomotor disorders have been poorly studied and understood. Therefore, no disease‐modifying treatment is usually considered. The study aimed to investigate the effect of the aqueous e…
View article: Potential Curative Effects of Aqueous Extracts of Cissus quadrangularis (Vitaceae) and Jatropha gossypiifolia (Euphorbiaceae) on Acetaminophen-Induced Liver Injury in Mice
Potential Curative Effects of Aqueous Extracts of Cissus quadrangularis (Vitaceae) and Jatropha gossypiifolia (Euphorbiaceae) on Acetaminophen-Induced Liver Injury in Mice Open
The results obtained are evidence in favor of the development of a formulation based on the extracts of these plants against liver diseases.
View article: Epidemiology of Male Sexual Dysfunction (MSD) in Patients Consulting in Some Health Services in the City of Douala, Cameroon
Epidemiology of Male Sexual Dysfunction (MSD) in Patients Consulting in Some Health Services in the City of Douala, Cameroon Open
Sexual dysfunction is a group of diseases, disorders or difficulties experienced by men or women during any stage of normal sexual activity. In Africa in general and Cameroon in particular, statistical data concerning the prevelance and th…
View article: The properties of Albizia ferruginea (Mimosaceae) stem bark aqueous extract on pro-inflammatory cytokines and hematological parameters among sub-chronic inflammation-induced rats
The properties of Albizia ferruginea (Mimosaceae) stem bark aqueous extract on pro-inflammatory cytokines and hematological parameters among sub-chronic inflammation-induced rats Open
The present research was carried out to evaluate the properties of Albizia ferruginea aqueous stem bark extract (AFASBE) on the variation of some pro-inflammatory cytokines and haematological parameters during sub-chronic inflammation. Sub…
View article: <i>Chromolaena odorata</i> (L.) R. M. King and H. Robinson Leaves Aqueous Extract Improves the Femoral Head in Ethanol‐Induced Osteonecrosis in Rats
<i>Chromolaena odorata</i> (L.) R. M. King and H. Robinson Leaves Aqueous Extract Improves the Femoral Head in Ethanol‐Induced Osteonecrosis in Rats Open
Chronic alcohol consumption damages bone formation and causes bone pathology, including osteonecrosis of the femoral head. The aim of this work was to evaluate the effects of the leaf aqueous extract of Chromolaena odorata ( C. odorata ) o…
View article: Study of the Subacute Toxicity of Dry Bark of Albizia ferruginea (Mimosaceae) (Guill. &Perr.) Berth. in Wistar Albino Rats
Study of the Subacute Toxicity of Dry Bark of Albizia ferruginea (Mimosaceae) (Guill. &Perr.) Berth. in Wistar Albino Rats Open
This present work aimed to assess the subacute toxicity of the total aqueous extract of the dry bark of Albizia ferruginea in rats. Subacute toxicity was done in accordance with 2008 OECD Guideline 407, for oral toxicity at a daily dose fo…
View article: Acute and Subchronic Toxicity Studies on the Aqueous Extract of the Plant Mixture (Bidens pilosa and Cymbopogon citratus Aerial Parts) in Rat Model
Acute and Subchronic Toxicity Studies on the Aqueous Extract of the Plant Mixture (Bidens pilosa and Cymbopogon citratus Aerial Parts) in Rat Model Open
Bidens pilosa (B. pilosa) and Cymbopogon citratus (C. citratus) are plants used individually or in combination in the traditional treatment of several ailments such as cardiovascular disorders. In order to valorise their traditional use, a…
View article: Ocimum gratissimum Leaves Aqueous Extract Can Minimize Middle Cerebral Artery Occlusion and Reperfusion-Induced Injury in Rat’s Brain
Ocimum gratissimum Leaves Aqueous Extract Can Minimize Middle Cerebral Artery Occlusion and Reperfusion-Induced Injury in Rat’s Brain Open
Background and Aim: Ocimum gratissimum is widely used in traditional medicine for its good antioxidant and anti-inflammatory activity. Stroke is an important factor of disability and death worldwide causing brain injury through oxidative s…
View article: Acute oral toxicity evaluation of hydroethanolic extract from stem and leaf powder of A. annua (Asteraceae) in laboratory rats
Acute oral toxicity evaluation of hydroethanolic extract from stem and leaf powder of A. annua (Asteraceae) in laboratory rats Open
Introduction: Development of a new galenic form containing vegetables extracts for paediatric use could be a good therapeutic alternative to overcome chemoresistance and therapeutic failures observed with conventional antimalarial drugs. T…
View article: Acute oral toxicity evaluation of hydroethanolic extract from stem and leaf powder of A. annua (Asteraceae) in laboratory rats
Acute oral toxicity evaluation of hydroethanolic extract from stem and leaf powder of A. annua (Asteraceae) in laboratory rats Open
Introduction: Development of a new galenic form containing vegetables extracts for paediatric use could be a good therapeutic alternative to overcome chemoresistance and therapeutic failures observed with conventional antimalarial drugs. T…