Therese Carlsson
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View article: Detecting <scp> <i>TP53</i> </scp> mutations in paired liquid and tissue biopsies from patients with high‐grade serous ovarian carcinoma
Detecting <span> <i>TP53</i> </span> mutations in paired liquid and tissue biopsies from patients with high‐grade serous ovarian carcinoma Open
High‐grade serous ovarian carcinoma (HGSC) is the most lethal form of ovarian carcinoma, often diagnosed at advanced stages due to non‐specific symptoms and the lack of reliable screening methods. This proof‐of‐concept study aimed to devel…
View article: Involvement of <scp>KEAP1</scp>/<scp>NRF2</scp> pathway in non‐<scp>BRAF</scp> mutated squamous cell carcinoma of the thyroid
Involvement of <span>KEAP1</span>/<span>NRF2</span> pathway in non‐<span>BRAF</span> mutated squamous cell carcinoma of the thyroid Open
Squamous cell carcinoma (SCC) of the thyroid is a rare tumor that is classified as an anaplastic thyroid cancer (ATC) due to its similar unresponsiveness to chemoradiotherapy and an outstandingly poor prognosis. Due to its rarity, current …
View article: Optimization of Pre-Analytical Handling to Maintain DNA Integrity in Diagnostic Papanicolaou Tests
Optimization of Pre-Analytical Handling to Maintain DNA Integrity in Diagnostic Papanicolaou Tests Open
Cell-free DNA (cfDNA) of ovarian carcinoma origin can be detected in samples from the gynecologic tract. This study aims to evaluate how pre-analytical handling affects DNA profile and integrity in Papanicolaou (Pap) tests, to optimize the…
View article: Resolving thyroid lineage cell trajectories merging into a dual endocrine gland in mammals
Resolving thyroid lineage cell trajectories merging into a dual endocrine gland in mammals Open
The thyroid has a remarkable evolution, appearing first as an integral presumably exocrine constituent of the chordate endostyle that is transformed into an endocrine gland during metamorphosis in basal vertebrates. In mammals, the thyroid…
View article: Asynchrony of Apical Polarization, Luminogenesis, and Functional Differentiation in the Developing Thyroid Gland
Asynchrony of Apical Polarization, Luminogenesis, and Functional Differentiation in the Developing Thyroid Gland Open
Follicular thyroid tissue originates from progenitors derived from a midline endodermal primordium. Current understanding infers that folliculogenesis in the embryonic thyroid designates the latest morphogenetic event taking place after th…
View article: Tissue architecture delineates field cancerization in BRAFV600E-induced tumor development
Tissue architecture delineates field cancerization in BRAFV600E-induced tumor development Open
Cancer cells hijack developmental growth mechanisms but whether tissue morphogenesis and architecture modify tumorigenesis is unknown. Here, we characterized a new mouse model of sporadic thyroid carcinogenesis based on inducible expressio…