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View article: Moisturising Gloves as a Solution for Occupational Skin Health: Advances and Challenges
Moisturising Gloves as a Solution for Occupational Skin Health: Advances and Challenges Open
Extended glove usage is crucial in various occupational settings to safeguard workers and maintain hygiene standards. However, prolonged wear creates an occlusive environment that disrupts normal skin evaporation, leading to temporary over…
View article: In Silico Analysis of Curcumin and Its Analogs MS13 and MS17 Against HSF1 and HSP Family Proteins
In Silico Analysis of Curcumin and Its Analogs MS13 and MS17 Against HSF1 and HSP Family Proteins Open
Heat shock proteins (HSPs), a family of proteins including HSP27, HSP40, HSP60, HSP70, and HSP90, play critical roles in cellular processes and are often dysregulated in cancer. Heat Shock Factor 1 (HSF1) protein, the master regulator of H…
View article: Editorial: Recent advances in small molecule-based targeted therapy for breast cancer
Editorial: Recent advances in small molecule-based targeted therapy for breast cancer Open
Citation: Htar TT, Naidu R, Lim V and Pandey AK (2023) Editorial: Recent advances in small molecule-based targeted therapy for breast cancer. Front. Pharmacol. 14:1343664. doi: 10.3389/fphar.2023.1343664
View article: Thiadiazine thione derivatives as anti-leishmanial agents: synthesis, biological evaluation, structure activity relationship, ADMET, molecular docking and molecular dynamics simulation studies
Thiadiazine thione derivatives as anti-leishmanial agents: synthesis, biological evaluation, structure activity relationship, ADMET, molecular docking and molecular dynamics simulation studies Open
During last decades, 3,5-disubstituted-tetrahydro-2H-thiadiazine-2-thione scaffold remains the center of interest due to their ease of preparation, diverse range substituents at N-3 and N-5 positions, and profound biological activit…
View article: The anti-melanogenic properties of Swietenia macrophylla king
The anti-melanogenic properties of Swietenia macrophylla king Open
Fair flawless skin is the goal for some cultures and the development of irregular skin pigmentation is considered an indication of premature skin aging. Hence, there is a rising demand for skin whitening cosmetics. Thus, this research will…
View article: Anti-Inflammatory and Anti-Rheumatic Potential of Selective Plant Compounds by Targeting TLR-4/AP-1 Signaling: A Comprehensive Molecular Docking and Simulation Approaches
Anti-Inflammatory and Anti-Rheumatic Potential of Selective Plant Compounds by Targeting TLR-4/AP-1 Signaling: A Comprehensive Molecular Docking and Simulation Approaches Open
Plants are an important source of drug development and numerous plant derived molecules have been used in clinical practice for the ailment of various diseases. The Toll-like receptor-4 (TLR-4) signaling pathway plays a crucial role in inf…
View article: Cosmeceutical Therapy: Engaging the Repercussions of UVR Photoaging on the Skin’s Circadian Rhythm
Cosmeceutical Therapy: Engaging the Repercussions of UVR Photoaging on the Skin’s Circadian Rhythm Open
Sunlight is an important factor in regulating the central circadian rhythm, including the modulation of our sleep/wake cycles. Sunlight had also been discovered to have a prominent influence on our skin’s circadian rhythm. Overexposure or …
View article: Biodistribution Study of Niosomes in Tumor-Implanted BALB/C Mice Using Scintigraphic Imaging
Biodistribution Study of Niosomes in Tumor-Implanted BALB/C Mice Using Scintigraphic Imaging Open
The purpose of this work was to study the biodistribution of niosomes in tumor-implanted BALB/c mice using gamma scintigraphy. Niosomes were first formulated and characterized, then radiolabeled with Technetium-99 m ( 99m Tc). The biodistr…
View article: In vitro and In silico Evaluation of Structurally Diverse Benzyl-pyrrolidine-3-ol Analogues as Apoptotic Agents via Caspase Activation
In vitro and In silico Evaluation of Structurally Diverse Benzyl-pyrrolidine-3-ol Analogues as Apoptotic Agents via Caspase Activation Open
The activation of caspases is central to apoptotic process in living systems. Defects in apoptosis have been implicated with carcinogenesis. Need to develop smart agents capable of inducing apoptosis in tumor cells is obvious. With this mo…
View article: The Potential of Sky Fruit as an Anti-Aging and Wound Healing Cosmeceutical Agent
The Potential of Sky Fruit as an Anti-Aging and Wound Healing Cosmeceutical Agent Open
There are many extrinsic factors that can contribute to the premature aging of the skin. In recent years, the demand for natural cosmetic from the general population has noticeable grow. Therefore, this research aimed to investigate the bi…
View article: Water Literacy in the Southeast Asian Context: Are We There Yet?
Water Literacy in the Southeast Asian Context: Are We There Yet? Open
The water situation in Southeast Asia has changed from one of relative abundance to one of relative scarcity. Conventional water management that strategized around the provision of adequate water supply to users has limited sustainability.…
View article: Is Curcumin the Answer to Future Chemotherapy Cocktail?
Is Curcumin the Answer to Future Chemotherapy Cocktail? Open
The rise in cancer cases in recent years is an alarming situation worldwide. Despite the tremendous research and invention of new cancer therapies, the clinical outcomes are not always reassuring. Cancer cells could develop several evasive…
View article: Simplified, Cost Effective, and Accurate Calculation of Critical Wavelength via the MATLAB Software
Simplified, Cost Effective, and Accurate Calculation of Critical Wavelength via the MATLAB Software Open
The use of sunscreens in our daily lives to reduce UV exposure on our skin is a good measure against photoaging. However, the current active ingredients in the market are not able to cover the entire spectrum range of UVA and UVB. Therefor…
View article: Counteracting the Ramifications of UVB Irradiation and Photoaging with Swietenia macrophylla King Seed
Counteracting the Ramifications of UVB Irradiation and Photoaging with Swietenia macrophylla King Seed Open
In this day and age, the expectation of cosmetic products to effectively slow down skin photoaging is constantly increasing. However, the detrimental effects of UVB on the skin are not easy to tackle as UVB dysregulates a wide range of mol…
View article: Combined docking methods and molecular dynamics to identify effective antiviral 2, 5-diaminobenzophenonederivatives against SARS-CoV-2
Combined docking methods and molecular dynamics to identify effective antiviral 2, 5-diaminobenzophenonederivatives against SARS-CoV-2 Open
The aim of this work is to contribute to the research in finding lead compounds for clinical use, to identify new drugs that target the SARS-CoV-2 virus main protease (Mpro). In this study, we used molecular docking strategies to analyze 2…
View article: Detrimental Effects of UVB on Retinal Pigment Epithelial Cells and Its Role in Age-Related Macular Degeneration
Detrimental Effects of UVB on Retinal Pigment Epithelial Cells and Its Role in Age-Related Macular Degeneration Open
Retinal pigment epithelial (RPE) cells are an essential part of the human eye because they not only mediate and control the transfer of fluids and solutes but also protect the retina against photooxidative damage and renew photoreceptor ce…
View article: Phytochemical Composition and Enzyme Inhibition Studies of Buxus papillosa C.K. Schneid
Phytochemical Composition and Enzyme Inhibition Studies of Buxus papillosa C.K. Schneid Open
The current research work is an endeavor to study the chemical profiling and enzyme-inhibition potential of different polarity solvent (n-hexane, dichloromethane—DCM and methanol—MeOH) extracts from the aerial and stem parts of Buxus papil…
View article: Deciphering the Binding Mechanism of Dexamethasone Against SARS-CoV-2 Main Protease: Computational Molecular Modelling Approach
Deciphering the Binding Mechanism of Dexamethasone Against SARS-CoV-2 Main Protease: Computational Molecular Modelling Approach Open
At present, there are no proven agents for the treatment of 2019 coronavirus disease (COVID-19). The available evidence has not allowed guidelines to clearly recommend any drugs outside the context of clinical trials. One of the most impor…
View article: Deciphering the Binding Mechanism of Dexamethasone Against SARS-CoV-2 Main Protease: Computational Molecular Modelling Approach
Deciphering the Binding Mechanism of Dexamethasone Against SARS-CoV-2 Main Protease: Computational Molecular Modelling Approach Open
At present, there are no proven agents for the treatment of 2019 coronavirus disease (COVID-19). The available evidence has not allowed guidelines to clearly recommend any drugs outside the context of clinical trials. One of the most impor…
View article: Retrospective and prospective validated high-throughput virtual screening approach for the identification of new GPER-1 modulators
Retrospective and prospective validated high-throughput virtual screening approach for the identification of new GPER-1 modulators Open
View article: Retrospective and prospective validated high-throughput virtual screening approach for the identification of new GPER-1 modulators
Retrospective and prospective validated high-throughput virtual screening approach for the identification of new GPER-1 modulators Open
View article: Retrospective and prospective validated high-throughput virtual screening approach for the identification of new GPER-1 modulators
Retrospective and prospective validated high-throughput virtual screening approach for the identification of new GPER-1 modulators Open
View article: HPLC–PDA Polyphenolic Quantification, UHPLC–MS Secondary Metabolite Composition, and In Vitro Enzyme Inhibition Potential of Bougainvillea glabra
HPLC–PDA Polyphenolic Quantification, UHPLC–MS Secondary Metabolite Composition, and In Vitro Enzyme Inhibition Potential of Bougainvillea glabra Open
The plants of the Bougainvillea genus are widely explored regarding nutritive and medicinal purposes. In this study, dichloromethane (DCM) and methanol (MeOH) extracts of Bougainvillea glabra (Choisy.) aerial and flower parts were analyzed…
View article: Illustrated step by step protocol to perform molecular docking: Human estrogen receptor complex with 4-hydroxytamoxifen as a case study
Illustrated step by step protocol to perform molecular docking: Human estrogen receptor complex with 4-hydroxytamoxifen as a case study Open
Molecular docking is one of the most frequently used technique in structure-based drug design. Molecular docking can predict the binding-conformation and interactions of small molecule to the appropriate binding site within the target prot…
View article: <p>Engineering of Naproxen Loaded Polymer Hybrid Enteric Microspheres for Modified Release Tablets: Development, Characterization, in silico Modelling and in vivo Evaluation</p>
Engineering of Naproxen Loaded Polymer Hybrid Enteric Microspheres for Modified Release Tablets: Development, Characterization, in silico Modelling and in vivo Evaluation Open
The current study concludes that developing NP loaded PHE-Ms based tablets could effectively reduce GIT consequences with restored therapeutic effects. The modified release pattern could improve the dissolution rate and enhancement of oral…
View article: Natural bioactive compounds as a new source of promising G protein-coupled estrogen receptor (GPER) modulators: comprehensive <i>in silico</i> approach
Natural bioactive compounds as a new source of promising G protein-coupled estrogen receptor (GPER) modulators: comprehensive <i>in silico</i> approach Open
Cancer ranks in second place among the cause of death worldwide. Cancer progress in multiple stages of carcinogenesis and metastasis programs through complex pathways. Sex hormones and their receptors are the major factors in promoting can…
View article: Cognitive Dysfunction in Diabetes Mellitus
Cognitive Dysfunction in Diabetes Mellitus Open
People with diabetes mellitus type 2 will have higher rate of cognitive impairment than people that do not. Besides that, the effect of diabetes on the normal mental functions is often disregarded. This may be due to a lack of signs and st…
View article: Model of Experimentation for Photoprotective Properties of Natural Products Against Ultraviolet C (UVC) Damage: A Case Study On Rosmarinic Acid
Model of Experimentation for Photoprotective Properties of Natural Products Against Ultraviolet C (UVC) Damage: A Case Study On Rosmarinic Acid Open
UVC is one of the three forms of ultraviolet radiation that is produced by the sun and is harmful to those who are exposed to it. On earth, our ozone layer acts as a filter against UVC (solar UVC) from the sun. However, this is not the cas…
View article: <p>Characterization, optimization, and in vitro evaluation of Technetium-99m-labeled niosomes</p>
Characterization, optimization, and in vitro evaluation of Technetium-99m-labeled niosomes Open
To our knowledge, this is the first study published on the surface chelation of niosomes with 99mTc. The formulated 99mTc-labeled niosomes possessed high radiolabeling efficacy, good stability in vitro, and show good …
View article: Sequential ligand- and structure-based virtual screening approach for the identification of potential G protein-coupled estrogen receptor-1 (GPER-1) modulators
Sequential ligand- and structure-based virtual screening approach for the identification of potential G protein-coupled estrogen receptor-1 (GPER-1) modulators Open
This paper presents the application of sequential ligand- and structure-based virtual screening approach for the identification of G protein-coupled estrogen receptor-1 (GPER-1/GPR30) modulators.