Tran Tinh Hien
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View article: Ethanol extract of Argyreia acuta leaves attenuates NSAID-induced gastric inflammation in mice via antioxidant and immunomodulatory mechanisms
Ethanol extract of Argyreia acuta leaves attenuates NSAID-induced gastric inflammation in mice via antioxidant and immunomodulatory mechanisms Open
Indomethacin, a widely used NSAID, induces gastric injury via prostaglandin depletion, oxidative stress, and immune imbalance. This study evaluated the gastroprotective effects of Argyreia acuta leaf ethanol extract (EEAAL) in a murine mod…
View article: A Multiple-Case Study of English Language Teacher Identity in Vietnamese Higher Education
A Multiple-Case Study of English Language Teacher Identity in Vietnamese Higher Education Open
This research examines the ways in which English lecturers in Vietnamese higher education negotiate their professional identities within the context of personal agency, institutional frameworks, and sociocultural expectations. Using a qual…
View article: The high-dose dual therapy for eradication of <i>Helicobacter pylori</i>: efficacy and safety
The high-dose dual therapy for eradication of <i>Helicobacter pylori</i>: efficacy and safety Open
Background. The article presents the results of a prospective open-label comparative interventional study of the efficacy and safety of high-dose dual therapy (HDDT) for eradicating Helicobacter pylori infection. Aim. To evaluate the effic…
View article: Kiến thức về lây nhiễm HIV qua quan hệ tình dục ở sinh viên nam tại Thành phố Hồ Chí Minh
Kiến thức về lây nhiễm HIV qua quan hệ tình dục ở sinh viên nam tại Thành phố Hồ Chí Minh Open
Đặt vấn đề: Trong những năm gần đây, tỷ lệ nhiễm HIV tại Việt Nam tăng lên đáng kể đặc biệt ở nam giới và nguyên nhân chủ yếu là do quan hệ tình dục (QHTD) không an toàn. Bên cạnh đó, việc không sử dụng bao cao su khi QHTD và thái độ dễ dã…
View article: Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples
Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples Open
We describe the MalariaGEN Pf7 data resource, the seventh release of Plasmodium falciparum genome variation data from the MalariaGEN network. It comprises over 20,000 samples from 82 partner studies in 33 countries, including several malar…
View article: A molecular barcode and web-based data analysis tool to identify imported Plasmodium vivax malaria
A molecular barcode and web-based data analysis tool to identify imported Plasmodium vivax malaria Open
View article: Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia
Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia Open
Background Understanding the effect of immunity on Plasmodium falciparum clearance is essential for interpreting therapeutic efficacy studies designed to monitor emergence of artemisinin drug resistance. In low-transmission areas of Southe…
View article: An open dataset of Plasmodium vivax genome variation in 1,895 worldwide samples
An open dataset of Plasmodium vivax genome variation in 1,895 worldwide samples Open
This report describes the MalariaGEN Pv4 dataset, a new release of curated genome variation data on 1,895 samples of Plasmodium vivax collected at 88 worldwide locations between 2001 and 2017. It includes 1,370 new samples contributed by M…
View article: Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study
Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study Open
Introduction Understanding the human immune response to Plasmodium falciparum gametocytes and its association with gametocytemia is essential for understanding the transmission of malaria as well as progressing transmission blocking vaccin…
View article: Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response Open
The emergence and spread of artemisinin-resistant Plasmodium falciparum , first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resist…
View article: Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis
Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis Open
Background The duration of trial follow-up affects the ability to detect recrudescent infections following anti-malarial treatment. The aim of this study was to explore the proportions of recrudescent parasitaemia as ascribed by genotyping…
View article: Development of weight and age-based dosing of daily primaquine for radical cure of vivax malaria
Development of weight and age-based dosing of daily primaquine for radical cure of vivax malaria Open
View article: Clustering of malaria in households in the Greater Mekong Subregion: operational implications for reactive case detection
Clustering of malaria in households in the Greater Mekong Subregion: operational implications for reactive case detection Open
View article: Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination
Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination Open
Background: National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables …
View article: Author response: Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination
Author response: Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination Open
View article: The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response.
The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response. Open
The emergence and spread of artemisinin resistant Plasmodium falciparum , first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria eliminations ambitions. To investigate the artemisinin resis…
View article: The mechanism of artemisinin resistance of <i>Plasmodium falciparum</i> malaria parasites originates in their initial transcriptional response
The mechanism of artemisinin resistance of <i>Plasmodium falciparum</i> malaria parasites originates in their initial transcriptional response Open
The emergence and spread of artemisinin resistant Plasmodium falciparum , first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria eliminations ambitions. To investigate the artemisinin resis…
View article: Genetic surveillance in the Greater Mekong Subregion and South Asia to support malaria control and elimination
Genetic surveillance in the Greater Mekong Subregion and South Asia to support malaria control and elimination Open
National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to imp…
View article: Pharmacogenetic assessment of tafenoquine efficacy in patients with Plasmodium vivax malaria
Pharmacogenetic assessment of tafenoquine efficacy in patients with Plasmodium vivax malaria Open
Plasmodium vivax has the largest geographic range of human malaria species and is challenging to manage and eradicate due to its ability to establish a dormant liver stage, the hypnozoite, which can reactivate leading to relapse. Until rec…
View article: Detecting geospatial patterns of Plasmodium falciparum parasite migration in Cambodia using optimized estimated effective migration surfaces
Detecting geospatial patterns of Plasmodium falciparum parasite migration in Cambodia using optimized estimated effective migration surfaces Open
Background Understanding the genetic structure of natural populations provides insight into the demographic and adaptive processes that have affected those populations. Such information, particularly when integrated with geospatial data, c…
View article: Duration of viral detection in throat and rectum of a patient with COVID-19
Duration of viral detection in throat and rectum of a patient with COVID-19 Open
The rapid spread of coronavirus disease 2019 (COVID-19) raises concern about a global pandemic. Knowledge about the duration of viral shedding remains important for patient management and infection control. We report the duration of viral …
View article: Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial
Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial Open
UK Department for International Development, Wellcome Trust, Bill & Melinda Gates Foundation, UK Medical Research Council, and US National Institutes of Health.
Mass drug administrations with dihydroartemisinin-piperaquine and single low dose primaquine to eliminate Plasmodium falciparum have only a transient impact on Plasmodium vivax: Findings from randomised controlled trials Open
View article: Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania
Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania Open
The human genetic factors that affect resistance to infectious disease are poorly understood. Here we report a genome-wide association study in 17,000 severe malaria cases and population controls from 11 countries, informed by sequencing o…
View article: Intracluster correlation coefficients in the Greater Mekong Subregion for sample size calculations of cluster randomized malaria trials
Intracluster correlation coefficients in the Greater Mekong Subregion for sample size calculations of cluster randomized malaria trials Open
View article: The probability of a sequential Plasmodium vivax infection following asymptomatic Plasmodium falciparum and P. vivax infections in Myanmar, Vietnam, Cambodia, and Laos
The probability of a sequential Plasmodium vivax infection following asymptomatic Plasmodium falciparum and P. vivax infections in Myanmar, Vietnam, Cambodia, and Laos Open
Background Adding 8-aminoquinoline to the treatment of falciparum, in addition to vivax malaria, in locations where infections with both species are prevalent could prevent vivax reactivation. The potential risk of haemolysis under a unive…
View article: The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: A systematic review and individual patient data meta-analysis
The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: A systematic review and individual patient data meta-analysis Open
In this study, we observed the risk of P. vivax recurrence at day 42 to be significantly lower following treatment with DP compared with AL, reflecting the longer period of post-treatment prophylaxis; this risk was reduced substantially by…
View article: A validation study of microscopy versus quantitative PCR for measuring Plasmodium falciparum parasitemia
A validation study of microscopy versus quantitative PCR for measuring Plasmodium falciparum parasitemia Open
View article: The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis Open
View article: Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study
Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study Open
Wellcome Trust, Bill & Melinda Gates Foundation, UK Medical Research Council, and UK Department for International Development.