Tse‐Lok Ho
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View article: Total Synthesis of Quebrachamine through Macrolactamization (Eur. J. Org. Chem. 15/2014)
Total Synthesis of Quebrachamine through Macrolactamization (Eur. J. Org. Chem. 15/2014) Open
The cover picture shows the spectacular scenery of the Guoxing Interchange, located in Nantou, Taiwan. The loop-like structure, lifted by the high piers up to 70 meters above the ground, equivalent to 23 stories, is the most high-rise inte…
View article: Regioselective Synthesis of Ellipticine
Regioselective Synthesis of Ellipticine Open
An eight-step synthesis of the tetracyclic pyridocarbazole alkaloid ellipticine (= 5,11-dimethyl-6H-pyrido[4,3-b]carbazole; 1a) in an overall yield of 13% is reported, starting from 4,7-dimethyl-1H-indene. Key steps were iodination, Suzuki…
View article: Synthesis of Eburnamine, Isoeburnamine, and Eburnamonine <i>via</i> a Spirocyclic Intermediate
Synthesis of Eburnamine, Isoeburnamine, and Eburnamonine <i>via</i> a Spirocyclic Intermediate Open
Racemic eburnamonine ( 1 ) was synthesized via 6 , an intermediate possessing local symmetry. Cleavage of the cyclopentene subunit led to pentacyclic aldehydes 8a / 8b which on subsequent borohydride and Wolff–Kishner reductions gave 12 . …
View article: Hydroltsis of Ketol Trimethylenedithioacetals. Attempted Synthesis of Yashabushiketol
Hydroltsis of Ketol Trimethylenedithioacetals. Attempted Synthesis of Yashabushiketol Open
w -ThaIUumlIII) trlnuamacetate has been shown to cleave dithlanes which contan hydraxy funcuons that other reagents fail.Hydrolysis of a dlrect precursor of yashabushiketol led to tetrahydro-rpymnes.however.Many methods far dethiaacetaliza…
View article: Deblocking of 2-Bromoethyl Esters via Thiazolium Salts
Deblocking of 2-Bromoethyl Esters via Thiazolium Salts Open
Carboxylic acids are recovered from 2-bromo-ethyl esters by successive treatment with 4-methyl-5-thiazoleethanol, sodium bicarbonate followed by pyrolysis and quenching with dilute acid.
View article: Ceric Ammonium Nitrate Oxidation of Cyclic Ketones
Ceric Ammonium Nitrate Oxidation of Cyclic Ketones Open
Ceric ammonium nitrate oxidation of cyclohexanone, cyclopentanone, and norbornanone gives nitrato-carboxylic acids, oxidation of adamantanone and adamantan-2-ol gives the lactone 14.
View article: Oxidative Degradation of a Podocarpic Acid Derivative
Oxidative Degradation of a Podocarpic Acid Derivative Open
The dichromate oxidation of methyl-7-methyl-6,8,11,13-podocarpatetraen-19-oate, (5), is reported.