Thiago A. Patente
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View article: S. mansoni -derived omega-1 prevents OVA-specific allergic airway inflammation via hampering of cDC2 migration
S. mansoni -derived omega-1 prevents OVA-specific allergic airway inflammation via hampering of cDC2 migration Open
Chronic infection with Schistosoma mansoni parasites is associated with reduced allergic sensitization in humans, while schistosome eggs protects against allergic airway inflammation (AAI) in mice. One of the main secretory/excretory molec…
View article: AMPK activation induces RALDH+ tolerogenic dendritic cells by rewiring glucose and lipid metabolism
AMPK activation induces RALDH+ tolerogenic dendritic cells by rewiring glucose and lipid metabolism Open
Dendritic cell (DC) activation and function are underpinned by profound changes in cellular metabolism. Several studies indicate that the ability of DCs to promote tolerance is dependent on catabolic metabolism. Yet the contribution of AMP…
View article: Author Correction: Metabolic heterogeneity of tissue-resident macrophages in homeostasis and during helminth infection
Author Correction: Metabolic heterogeneity of tissue-resident macrophages in homeostasis and during helminth infection Open
View article: High-mannose glycans from Schistosoma mansoni eggs are important for priming of Th2 responses via Dectin-2 and prostaglandin E2
High-mannose glycans from Schistosoma mansoni eggs are important for priming of Th2 responses via Dectin-2 and prostaglandin E2 Open
The parasitic helminth Schistosoma mansoni is a potent inducer of type 2 immune responses by stimulating dendritic cells (DCs) to prime T helper 2 (Th2) responses. We previously found that S. mansoni soluble egg antigens (SEA) promote the …
View article: Metabolic heterogeneity of tissue-resident macrophages in homeostasis and during helminth infection
Metabolic heterogeneity of tissue-resident macrophages in homeostasis and during helminth infection Open
View article: AMPK activation induces RALDH<sup>high</sup>tolerogenic dendritic cells through rewiring of glucose and lipid metabolism
AMPK activation induces RALDH<sup>high</sup>tolerogenic dendritic cells through rewiring of glucose and lipid metabolism Open
It is well known that dendritic cell (DC) activation and function are underpinned by profound changes in cellular metabolism. Several studies indicate that the ability of DCs to promote tolerance is dependent on catabolic metabolism. The A…
View article: Dendritic cell–intrinsic LKB1-AMPK/SIK signaling controls metabolic homeostasis by limiting the hepatic Th17 response during obesity
Dendritic cell–intrinsic LKB1-AMPK/SIK signaling controls metabolic homeostasis by limiting the hepatic Th17 response during obesity Open
Obesity-associated metabolic inflammation drives the development of insulin resistance and type 2 diabetes, notably through modulating innate and adaptive immune cells in metabolic organs. The nutrient sensor liver kinase B1 (LKB1) has rec…
View article: Increased stromal PFKFB3-mediated glycolysis in inflammatory bowel disease contributes to intestinal inflammation
Increased stromal PFKFB3-mediated glycolysis in inflammatory bowel disease contributes to intestinal inflammation Open
Inflammatory bowel disease (IBD) is a chronic relapsing inflammation of the intestinal tract with currently not well-understood pathogenesis. In addition to the involvement of immune cells, increasing studies show an important role for fib…
View article: mTORC1 signaling in antigen-presenting cells of the skin restrains CD8+ T cell priming
mTORC1 signaling in antigen-presenting cells of the skin restrains CD8+ T cell priming Open
View article: Spectral flow cytometry reveals metabolic heterogeneity in tissue macrophages
Spectral flow cytometry reveals metabolic heterogeneity in tissue macrophages Open
Summary Tissue-macrophage populations are constituted by a mosaic of phenotypes, yet new methods are needed to link metabolic status to the range of phenotypes in vivo . We therefore designed a high-dimensional panel for spectral flow cyto…
View article: Fasciola hepatica Fatty Acid Binding Protein 1 Modulates T cell Polarization by Promoting Dendritic Cell Thrombospondin-1 Secretion Without Affecting Metabolic Homeostasis in Obese Mice
Fasciola hepatica Fatty Acid Binding Protein 1 Modulates T cell Polarization by Promoting Dendritic Cell Thrombospondin-1 Secretion Without Affecting Metabolic Homeostasis in Obese Mice Open
Background The parasitic trematode Fasciola hepatica evades host immune defenses through secretion of various immunomodulatory molecules. Fatty Acid Binding Proteins ( fh FABPs) are among the main excreted/secreted proteins and have been s…
View article: <i>Fasciola hepatica</i> Fatty Acid Binding Protein 1 modulates T cell polarization by promoting dendritic cell thrombospondin-1 secretion without affecting metabolic homeostasis in obese mice
<i>Fasciola hepatica</i> Fatty Acid Binding Protein 1 modulates T cell polarization by promoting dendritic cell thrombospondin-1 secretion without affecting metabolic homeostasis in obese mice Open
Background The parasitic trematode Fasciola hepatica evades host immune defenses through secretion of various immunomodulatory molecules. Fatty Acid Binding Proteins ( fh FABPs) are among the main excreted/secreted proteins and have been s…
View article: Acetate Improves the Killing of Streptococcus pneumoniae by Alveolar Macrophages via NLRP3 Inflammasome and Glycolysis-HIF-1α Axis
Acetate Improves the Killing of Streptococcus pneumoniae by Alveolar Macrophages via NLRP3 Inflammasome and Glycolysis-HIF-1α Axis Open
Short-chain fatty acids (SCFAs) are metabolites produced mainly by the gut microbiota with a known role in immune regulation. Acetate, the major SCFA, is described to disseminate to distal organs such as lungs where it can arm sentinel cel…
View article: LKB1 signalling in dendritic cells controls whole-body metabolic homeostasis by limiting T helper 17 priming
LKB1 signalling in dendritic cells controls whole-body metabolic homeostasis by limiting T helper 17 priming Open
Obesity-associated metaflammation drives the development of insulin resistance and type 2 diabetes, notably through modulating innate and adaptive immune cells in metabolic organs. The nutrient sensor liver kinase B1 (LKB1) has recently be…
View article: mTORC1 Signalling in Antigen-Presenting Cells of the Skin Restrains CD8+ T Cell Priming
mTORC1 Signalling in Antigen-Presenting Cells of the Skin Restrains CD8+ T Cell Priming Open
View article: Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid
Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid Open
Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease characterized by insulin-producing pancreatic β-cell destruction and hyperglycemia. While monocytes and NOD-like receptor family-pyrin domain containing 3 (NLRP3) are associate…
View article: Vias de regulação metabólicas em células dendríticas com viés tolerogênico
Vias de regulação metabólicas em células dendríticas com viés tolerogênico Open
O diabetes mellitus tipo 1 (DM1) é uma doença autoimune na qual células dendríticas (DC) desempenham um papel relevante. DC são células apresentadoras de antígenos, centrais para a diferenciação de células T CD4+, incluindo células T re…
View article: Abstract 2800: Oral cancer cell-derived extracellular vesicles can modulate an immunosuppressive microenvironment through M2 phenotype polarization
Abstract 2800: Oral cancer cell-derived extracellular vesicles can modulate an immunosuppressive microenvironment through M2 phenotype polarization Open
Oral squamous cell carcinoma (OSCC) is the most prevalent malignant tumor among head and neck cancers, with 300,000 new cases and 145,000 deaths around the world per year, with less than 50% survival rate of advanced cases after five years…
View article: Frequency determination of breast tumor-reactive CD4 and CD8 T cells in humans: unveiling the antitumor immune response
Frequency determination of breast tumor-reactive CD4 and CD8 T cells in humans: unveiling the antitumor immune response Open
As cancer immunotherapy gains importance, the determination of a patient's ability to react to his/her tumor is unquestionably relevant. Though the presence of T cells that recognize specific tumor antigens is well established, the total f…
View article: Allelic variations in genes belonging to glutathione system increase proliferative retinopathy risk in type 1 diabetes individuals
Allelic variations in genes belonging to glutathione system increase proliferative retinopathy risk in type 1 diabetes individuals Open
The functional SNPs rs17883901 and rs713041 modulate the risk for PDR in the studied population of T1D individuals, widening the spectrum of candidate genes for this complication.
View article: LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells
LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells Open
View article: Dendritic cells are what they eat: how their metabolism shapes T helper cell polarization
Dendritic cells are what they eat: how their metabolism shapes T helper cell polarization Open
Dendritic cells (DCs) are professional antigen-presenting cells that play a crucial role in the priming and differentiation of CD4+ T cells into several distinct subsets including effector T helper (Th) 1, Th17 and Th2 cells, as…
View article: Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy
Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy Open
Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve T cell activation and effector differentiation. They are, likewise, involved in the induction and maintenance of immune tolerance in homeostatic …
View article: Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes
Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes Open
Cardiac autonomic neuropathy is a neglected diabetic chronic complication for which genetic predictors are rarely reported. Oxidative stress is implicated in the pathogenesis of microvascular complications, and glutathione peroxidase 4 is …
View article: Gain-of-function variants in NLRP1 protect against the development of diabetic kidney disease: NLRP1 inflammasome role in metabolic stress sensing?
Gain-of-function variants in NLRP1 protect against the development of diabetic kidney disease: NLRP1 inflammasome role in metabolic stress sensing? Open
View article: Glutathione peroxidase-1 gene (GPX1) variants, oxidative stress and risk of kidney complications in people with type 1 diabetes
Glutathione peroxidase-1 gene (GPX1) variants, oxidative stress and risk of kidney complications in people with type 1 diabetes Open
View article: Linkage disequilibrium with HLA-DRB1-DQB1 haplotypes explains the association of TNF-308G>A variant with type 1 diabetes in a Brazilian cohort
Linkage disequilibrium with HLA-DRB1-DQB1 haplotypes explains the association of TNF-308G>A variant with type 1 diabetes in a Brazilian cohort Open
View article: Allelic variations in the CYBA gene of NADPH oxidase and risk of kidney complications in patients with type 1 diabetes
Allelic variations in the CYBA gene of NADPH oxidase and risk of kidney complications in patients with type 1 diabetes Open
View article: Association of a variant in the regulatory region of NADPH oxidase 4 gene and metabolic syndrome in patients with chronic hepatitis C
Association of a variant in the regulatory region of NADPH oxidase 4 gene and metabolic syndrome in patients with chronic hepatitis C Open
The results suggest that the evaluated NOX4 and CYBA SNPs are not direct genetic determinants of fibrosis in HCV patients, but nevertheless NOX4 rs3017887 SNP could indirectly influence fibrosis susceptibility due to its inverse associatio…
View article: Association of single nucleotide polymorphisms in the gene encoding GLUT1 and diabetic nephropathy in Brazilian patients with type 1 diabetes mellitus
Association of single nucleotide polymorphisms in the gene encoding GLUT1 and diabetic nephropathy in Brazilian patients with type 1 diabetes mellitus Open