Thomas Ludwig
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View article: Genome-wide SNPs reveal adaptation and population structure in Syagrus romanzoffiana (Arecaceae) from southern South America
Genome-wide SNPs reveal adaptation and population structure in Syagrus romanzoffiana (Arecaceae) from southern South America Open
Palms play crucial ecological and economic roles, and Syagrus romanzoffiana is a widely distributed species in South America. Despite its ecological importance and economic potential, population-level genetic studies of this palm remain li…
View article: Genome-wide SNP analysis: adaptation and population structure of Syagrus romanzoffiana (Cham.) Glassman (Arecaceae) in South America
Genome-wide SNP analysis: adaptation and population structure of Syagrus romanzoffiana (Cham.) Glassman (Arecaceae) in South America Open
Palms play a crucial ecological and economic role, with Syagrus romanzoffiana being a prominent species in South America. Despite its widespread distribution and economic potential, genetic studies on this species remain limited. This stud…
View article: Easy-PSAP: An Integrated Workflow to Prioritize Pathogenic Variants in Sequence Data from a Single Individual
Easy-PSAP: An Integrated Workflow to Prioritize Pathogenic Variants in Sequence Data from a Single Individual Open
Introduction: Next-generation sequencing (NGS) data analysis has become an integral part of clinical genetic diagnosis, raising the question of variant prioritization. The Population Sampling Probability (PSAP) method has been developed to…
View article: Trace element and OH content of quartz grains in the Amazon river: Potential application in provenance analysis
Trace element and OH content of quartz grains in the Amazon river: Potential application in provenance analysis Open
Quartz grains in sediment carried by the Amazon River and five of its major tributaries were analyzed by FTIR-spectroscopy and secondary ion mass spectrometry to evaluate their potential for provenance analysis. Additionally, heavy mineral…
View article: Elucidação dos mecanismos de resistência múltipla aos inibidores da EPSPS e ACCase e custo de adaptabilidade de >i<Digitaria insularis>/i<
Elucidação dos mecanismos de resistência múltipla aos inibidores da EPSPS e ACCase e custo de adaptabilidade de >i/i< Open
View article: A simple demonstration of a privacy-preserving de-centralised genotype imputation workflow
A simple demonstration of a privacy-preserving de-centralised genotype imputation workflow Open
Recently, a number of studies have looked at the problem of privacy and data-sharing restrictions in the context of missing genotype imputation servers. This relates to the most typical imputation pipelines which involve a whole-genome seq…
View article: Enhancing the annotation of small ORF-altering variants using MORFEE: introducing MORFEEdb, a comprehensive catalog of SNVs affecting upstream ORFs in human 5′UTRs
Enhancing the annotation of small ORF-altering variants using MORFEE: introducing MORFEEdb, a comprehensive catalog of SNVs affecting upstream ORFs in human 5′UTRs Open
Non-canonical small open reading frames (sORFs) are among the main regulators of gene expression. The most studied of these are upstream ORFs (upORFs) located in the 5′-untranslated region (UTR) of coding genes. Internal ORFs (intORFs) in …
View article: Effect of Pleasant and Unplesant Odors on Auditory Asymmetry: A Dichotic Listening Study
Effect of Pleasant and Unplesant Odors on Auditory Asymmetry: A Dichotic Listening Study Open
View article: SURFBAT: a surrogate family based association test building on large imputation reference panels
SURFBAT: a surrogate family based association test building on large imputation reference panels Open
Genotype–phenotype association tests are typically adjusted for population stratification using principal components that are estimated genome-wide. This lacks resolution when analyzing populations with fine structure and/or individuals wi…
View article: Enhancing the annotation of small ORF-altering variants using MORFEE: introducing MORFEEdb, a comprehensive catalog of SNVs affecting upstream ORFs in human 5’UTRs
Enhancing the annotation of small ORF-altering variants using MORFEE: introducing MORFEEdb, a comprehensive catalog of SNVs affecting upstream ORFs in human 5’UTRs Open
Non-canonical small Open Reading Frames (sORFs) are among main regulators of gene expression. The most studied ones are upstream ORFs (upORFs) located in the 5’UTR of coding genes. Internal ORFs (intORFs) in the coding sequence and downstr…
View article: Human genetic structure in Northwest France provides new insights into West European historical demography
Human genetic structure in Northwest France provides new insights into West European historical demography Open
The demographical history of France remains largely understudied despite its central role toward understanding modern population structure across Western Europe. Here, by exploring publicly available Europe-wide genotype datasets together …
View article: How local reference panels improve imputation in French populations
How local reference panels improve imputation in French populations Open
Imputation servers offer the exclusive possibility to harness the largest public reference panels which have been shown to deliver very high precision in the imputation of European genomes. Many studies have nonetheless stressed the import…
View article: Data from EphB4 Promotes Site-Specific Metastatic Tumor Cell Dissemination by Interacting with Endothelial Cell–Expressed EphrinB2
Data from EphB4 Promotes Site-Specific Metastatic Tumor Cell Dissemination by Interacting with Endothelial Cell–Expressed EphrinB2 Open
The tyrosine kinase receptor EphB4 interacts with its ephrinB2 ligand to act as a bidirectional signaling system that mediates adhesion, migration, and guidance by controlling attractive and repulsive activities. Recent findings have shown…
View article: Data from EphB4 Promotes Site-Specific Metastatic Tumor Cell Dissemination by Interacting with Endothelial Cell–Expressed EphrinB2
Data from EphB4 Promotes Site-Specific Metastatic Tumor Cell Dissemination by Interacting with Endothelial Cell–Expressed EphrinB2 Open
The tyrosine kinase receptor EphB4 interacts with its ephrinB2 ligand to act as a bidirectional signaling system that mediates adhesion, migration, and guidance by controlling attractive and repulsive activities. Recent findings have shown…
View article: Heritable defects in telomere and mitotic function selectively predispose to sarcomas
Heritable defects in telomere and mitotic function selectively predispose to sarcomas Open
Cancer genetics has to date focused on epithelial malignancies, identifying multiple histotype-specific pathways underlying cancer susceptibility. Sarcomas are rare malignancies predominantly derived from embryonic mesoderm. To identify pa…
View article: Low-T sheared peridotites from the Kaapvaal-craton: Record of hydrous metasomatism during deformation
Low-T sheared peridotites from the Kaapvaal-craton: Record of hydrous metasomatism during deformation Open
View article: Early planetesimal accretion and magmatic records in achondrite meteorites
Early planetesimal accretion and magmatic records in achondrite meteorites Open
Achondrite meteorites record the earliest evidence of volcanic activity in the Solar System.The 182 Hf-182 W records of noncarbonaceous (NC) iron meteorites provide model ages for core formation as early as 0.3 Myr after calcium-aluminium-…
View article: Al-Mg and U-Pb chronological records of Erg Chech 002 ungrouped achondrite meteorite
Al-Mg and U-Pb chronological records of Erg Chech 002 ungrouped achondrite meteorite Open
View article: Testing for association with rare variants in the coding and non-coding genome: RAVA-FIRST, a new approach based on CADD deleteriousness score
Testing for association with rare variants in the coding and non-coding genome: RAVA-FIRST, a new approach based on CADD deleteriousness score Open
Rare variant association tests (RVAT) have been developed to study the contribution of rare variants widely accessible through high-throughput sequencing technologies. RVAT require to aggregate rare variants in testing units and to filter …
View article: Moment estimators of relatedness from low-depth whole-genome sequencing data
Moment estimators of relatedness from low-depth whole-genome sequencing data Open
View article: A homozygous splice variant in <scp><i>ATP5PO</i></scp>, disrupts mitochondrial complex V function and causes Leigh syndrome in two unrelated families
A homozygous splice variant in <span><i>ATP5PO</i></span>, disrupts mitochondrial complex V function and causes Leigh syndrome in two unrelated families Open
Mitochondrial complex V plays an important role in oxidative phosphorylation by catalyzing the generation of ATP. Most complex V subunits are nuclear encoded and not yet associated with recognized Mendelian disorders. Using exome sequencin…
View article: Genetic population structure across Brittany and the downstream Loire basin provides new insights on the demographic history of Western Europe
Genetic population structure across Brittany and the downstream Loire basin provides new insights on the demographic history of Western Europe Open
European genetic ancestry originates from three main ancestral populations - Western hunter-gatherers, early European farmers and Yamnaya Eurasian herders - whose edges geographically met in present-day France. Despite its central role to …
View article: Testing for association with rare variants in the coding and non-coding genome: RAVA-FIRST, a new approach based on CADD deleteriousness score
Testing for association with rare variants in the coding and non-coding genome: RAVA-FIRST, a new approach based on CADD deleteriousness score Open
Rare variant association tests (RVAT) have been developed to study the contribution of rare variants widely accessible through high-throughput sequencing technologies. RVAT require to aggregate rare variants in testing units and to filter …
View article: Early and sequential formation of planetesimals in an outer region of the protoplanetary disc
Early and sequential formation of planetesimals in an outer region of the protoplanetary disc Open
Isotopic anomalies in meteorites have revealed two reservoirs of planetesimal formation corresponding to non-carbonaceous (NC) and carbonaceous (C) compositions sampling the inner and more outer regions of the disc respectively (Kruijer et…
View article: Alumino-oxy-rossmanite from pegmatites in Variscan metamorphic rocks from Eibenstein an der Thaya, Lower Austria, Austria: A new tourmaline that represents the most Al-rich end-member composition
Alumino-oxy-rossmanite from pegmatites in Variscan metamorphic rocks from Eibenstein an der Thaya, Lower Austria, Austria: A new tourmaline that represents the most Al-rich end-member composition Open
Alumino-oxy-rossmanite, ideally ☐Al3Al6(Si5AlO18)(BO3)3(OH)3O, is here described as a new member of the tourmaline supergroup. It is an early magmatic Al-rich oxy-tourmaline from a small pegmatitic body embedded in amphibolite and biotite-…
View article: Graphite in ureilites, enstatite chondrites, and unique clasts in ordinary chondrites – Insights from the carbon-isotope composition
Graphite in ureilites, enstatite chondrites, and unique clasts in ordinary chondrites – Insights from the carbon-isotope composition Open
Carbon is of fundamental interest for constraining the volatile element inventory of terrestrial planets. In some meteorites, like ureilites and enstatite chondrites, graphite is the major carbon-carrier. Here, we report the in-situ analys…
View article: A hidden Rodinian lithospheric keel beneath Zealandia, Earth’s newly recognized continent
A hidden Rodinian lithospheric keel beneath Zealandia, Earth’s newly recognized continent Open
We present a data set of >1500 in situ O-Hf-U-Pb zircon isotope analyses that document the existence of a concealed Rodinian lithospheric keel beneath continental Zealandia. The new data reveal the presence of a distinct isotopic domain…
View article: Land-sea correlations in the Eastern Mediterranean region over the past c. 800 kyr based on macro- and cryptotephras from ODP Site 964 (Ionian Basin)
Land-sea correlations in the Eastern Mediterranean region over the past c. 800 kyr based on macro- and cryptotephras from ODP Site 964 (Ionian Basin) Open
View article: Whole exome sequencing, a hypothesis-free approach to investigate recurrent early miscarriage
Whole exome sequencing, a hypothesis-free approach to investigate recurrent early miscarriage Open
View article: Rapid and repeated accretion of planetesimals in an outer region of the protoplanetary disc
Rapid and repeated accretion of planetesimals in an outer region of the protoplanetary disc Open