Thibauld Oullier
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View article: Microbial metabolites alleviate Aß-induced alterations of intestinal epithelial barrier and enteric nervous system connectivity
Microbial metabolites alleviate Aß-induced alterations of intestinal epithelial barrier and enteric nervous system connectivity Open
Amyloid-ß (Aß) induced alterations in gut functions, such as reduced motility and compromised barrier integrity contribute to age-related frailty. Therefore, developing fermentation-based products to prevent age-related gut disorders repre…
View article: Elevated levels of colonic interleukin-1beta and interleukin-8 in isolated REM sleep behavior disorder without associated changes in permeability
Elevated levels of colonic interleukin-1beta and interleukin-8 in isolated REM sleep behavior disorder without associated changes in permeability Open
Some recent studies suggest that gastrointestinal inflammation could play a role in the development of Parkinson’s disease (PD) by increasing intestinal permeability and triggering early neuropathological changes in the gut. Therefore, we …
View article: Characterization and Regulation of Alpha‐Synuclein Phosphorylation in Enteric Neurons
Characterization and Regulation of Alpha‐Synuclein Phosphorylation in Enteric Neurons Open
Alpha‐synuclein is a 140 aa neuronal protein pathologically and genetically linked to Parkinson's disease (PD). In PD, the major protein modification of alpha‐synuclein is phosphorylation at serine 129. Alpha‐synuclein phosphorylation also…
View article: Characterization and regulation of alpha-synuclein phosphorylation in enteric neurons under physiological conditions
Characterization and regulation of alpha-synuclein phosphorylation in enteric neurons under physiological conditions Open
View article: Confocal laser endomicroscopy as predictive biomarker of clinical and endoscopic efficacy of vedolizumab in ulcerative colitis: The DETECT study
Confocal laser endomicroscopy as predictive biomarker of clinical and endoscopic efficacy of vedolizumab in ulcerative colitis: The DETECT study Open
Aims In patients with ulcerative colitis (UC), no biomarker is available to help the physician to choose the most suitable biotherapy. The primary objective of this pilot study was to assess the feasibility of identification of α4β7- and T…
View article: The regulation of enteric neuron connectivity by semaphorin 5A is affected by the autism-associated S956G missense mutation
The regulation of enteric neuron connectivity by semaphorin 5A is affected by the autism-associated S956G missense mutation Open
View article: Characterization of mitochondria-associated ER membranes in the enteric nervous system under physiological and pathological conditions
Characterization of mitochondria-associated ER membranes in the enteric nervous system under physiological and pathological conditions Open
Our work shows for the first time the presence of contacts between endoplasmic reticulum and mitochondria in the enteric neurons and that the dynamic of these contacts is affected in these cells from an age-related neurodegeneration mouse …
View article: <scp>NALCN</scp>‐mediated sodium influx confers metastatic prostate cancer cell invasiveness
<span>NALCN</span>‐mediated sodium influx confers metastatic prostate cancer cell invasiveness Open
View article: Tau expression and phosphorylation in enteroendocrine cells
Tau expression and phosphorylation in enteroendocrine cells Open
Background and objective There is mounting evidence to suggest that the gut-brain axis is involved in the development of Parkinson’s disease (PD). In this regard, the enteroendocrine cells (EEC), which faces the gut lumen and are connected…
View article: Supplementary Figures 1 - 5 from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases
Supplementary Figures 1 - 5 from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases Open
PDF file - 579K, S1. Validation of the MDA-MB-435s cell system expressing luciferase gene and expressing or not KCNN3 gene. S2. SK3 knockdown reduced the development of metastases in cancer cell xenograft models. A) SK3 knockdown reduced t…
View article: Supplementary Methods from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases
Supplementary Methods from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases Open
PDF file - 128K
View article: Data from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases
Data from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases Open
The SK3 channel, a potassium channel, was recently shown to control cancer cell migration, a critical step in metastasis outgrowth. Here, we report that expression of the SK3 channel was markedly associated with bone metastasis. The SK3 ch…
View article: Supplementary Methods from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases
Supplementary Methods from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases Open
PDF file - 128K
View article: Supplementary Figures 1 - 5 from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases
Supplementary Figures 1 - 5 from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases Open
PDF file - 579K, S1. Validation of the MDA-MB-435s cell system expressing luciferase gene and expressing or not KCNN3 gene. S2. SK3 knockdown reduced the development of metastases in cancer cell xenograft models. A) SK3 knockdown reduced t…
View article: Data from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases
Data from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases Open
The SK3 channel, a potassium channel, was recently shown to control cancer cell migration, a critical step in metastasis outgrowth. Here, we report that expression of the SK3 channel was markedly associated with bone metastasis. The SK3 ch…
View article: Tau expression and phosphorylation in enteroendocrine cells
Tau expression and phosphorylation in enteroendocrine cells Open
Background and objective There is mounting evidence to suggest that the gut-brain axis is involved in the development of Parkinson’s disease (PD). In this regard, the enteroendocrine cells (EEC), which faces the gut lumen and are connected…
View article: Psychological stress induces an increase in cholinergic enteric neuromuscular pathways mediated by glucocorticoid receptors
Psychological stress induces an increase in cholinergic enteric neuromuscular pathways mediated by glucocorticoid receptors Open
Introduction Repeated acute stress (RASt) is known to be associated with gastrointestinal dysfunctions. However, the mechanisms underlying these effects have not yet been fully understood. While glucocorticoids are clearly identified as st…
View article: P320 Confocal Laser Endomicroscopy to predict the efficacy of vedolizumab as first-line biotherapy in ulcerative colitis
P320 Confocal Laser Endomicroscopy to predict the efficacy of vedolizumab as first-line biotherapy in ulcerative colitis Open
Background There is no biomarker to guide first-line of biotherapy in ulcerative colitis (UC). The main objective of this multicenter pilot study was to demonstrate the feasibility of identifying a4b7 and/or TNF-a expressing cells by dual-…
View article: Faeces‐derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases
Faeces‐derived extracellular vesicles participate in the onset of barrier dysfunction leading to liver diseases Open
The role of extracellular vesicles (EVs) from faeces (fEVs) and small circulating EVs (cEVs) in liver diseases such as non‐alcoholic fatty diseases (NAFLD) and non‐alcoholic steatohepatitis (NASH) has not been demonstrated. fEVs and cEVs o…
View article: Erratum to “Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis” [EBioMedicine 49 (2019) 172–188]
Erratum to “Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis” [EBioMedicine 49 (2019) 172–188] Open
The publisher regrets that due to a production error, supplemental figures were accidentally omitted from the published version of this research paper. The original article has been updated. The publisher would like to apologise for any in…
View article: Could the Microbiota Be a Predictive Factor for the Clinical Response to Probiotic Supplementation in IBS-D? A Cohort Study
Could the Microbiota Be a Predictive Factor for the Clinical Response to Probiotic Supplementation in IBS-D? A Cohort Study Open
Background: Increasing evidence suggests the beneficial effects of probiotics in irritable bowel syndrome (IBS), but little is known about how they can impact the gut microbiota. Our objective was to evaluate the effects of a multistrain p…
View article: TRPM8 as an Anti–Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination
TRPM8 as an Anti–Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination Open
In the fight against prostate cancer (PCa), TRPM8 is one of the most promising clinical targets. Indeed, several studies have highlighted that TRPM8 involvement is key in PCa progression because of its impact on cell proliferation, viabili…
View article: Psychological Stress Induces an Increase in Cholinergic Enteric Neuromuscular Pathways Mediated by Glucocorticoid Receptors
Psychological Stress Induces an Increase in Cholinergic Enteric Neuromuscular Pathways Mediated by Glucocorticoid Receptors Open
Repeated acute stress (RASt) is known to be associated with gastrointestinal dysfunctions. However, mechanisms underlying these effects are not fully understood. While glucocorticoids are clearly identified as hormones of stress, their imp…
View article: The ephrin receptor EphB2 regulates the connectivity and activity of enteric neurons
The ephrin receptor EphB2 regulates the connectivity and activity of enteric neurons Open
View article: Synthetic alkyl-ether-lipid promotes TRPV2 channel trafficking trough PI3K/Akt-girdin axis in cancer cells and increases mammary tumour volume
Synthetic alkyl-ether-lipid promotes TRPV2 channel trafficking trough PI3K/Akt-girdin axis in cancer cells and increases mammary tumour volume Open
View article: Expression of neuronal Na+ leak channel, NALCN, provides for persistent invasion of metastasizing cancer cells
Expression of neuronal Na+ leak channel, NALCN, provides for persistent invasion of metastasizing cancer cells Open
Cytosolic Ca2+ oscillations provide signaling input to several effector systems of the cell. These include neuronal development, migration and networking. Although similar signaling events are hijacked by highly aggressive cancer cells, th…
View article: Tau accumulates in Crohn's disease gut
Tau accumulates in Crohn's disease gut Open
A sizeable body of evidence has recently emerged to suggest that gastrointestinal (GI) inflammation might be involved in the development of Parkinson's disease (PD). There is now strong epidemiological and genetical evidence linking PD to …
View article: Optimizing filter trap assay for the detection of aggregated alpha-synuclein in brain samples
Optimizing filter trap assay for the detection of aggregated alpha-synuclein in brain samples Open
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View article: Tau accumulates in Crohn’s disease gut
Tau accumulates in Crohn’s disease gut Open
A sizeable body of evidence has recently emerged to suggest that gastrointestinal inflammation might be involved in the development of Parkinson’s disease. There is now strong epidemiological and genetical evidence linking Parkinson’s dise…
View article: Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis
Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis Open