Thibault Kervarrec
YOU?
Author Swipe
View article: High-resolution spatial transcriptomics uncover epidermal-dermal divergences in Merkel cell carcinoma: spatial context reshapes the gene expression landscape
High-resolution spatial transcriptomics uncover epidermal-dermal divergences in Merkel cell carcinoma: spatial context reshapes the gene expression landscape Open
View article: Marek’s disease virus replication in chicken skin reconstructed in vitro: evidence for viral particles in corneocytes
Marek’s disease virus replication in chicken skin reconstructed in vitro: evidence for viral particles in corneocytes Open
Marek’s disease (MD) is a lethal lymphoma of chickens, which is caused by MD virus (MDV), an alphaherpesvirus. MDV infects epithelial cells of the skin appendages, notably feather follicles, replicates in these cells and is shed into the e…
View article: Advancing sarcoma diagnostics with expanded DNA methylation-based classification
Advancing sarcoma diagnostics with expanded DNA methylation-based classification Open
Purpose Sarcomas pose a severe diagnostic challenge. A wide variety of these distinct entities need to be distinguished from each other and from less aggressive types of mesenchymal tumors, to ensure correct clinical management. A machine …
View article: Methylation analysis as a diagnostic tool for sweat gland tumours classification with emphasis on the distinction between digital papillary adenocarcinoma and mimickers
Methylation analysis as a diagnostic tool for sweat gland tumours classification with emphasis on the distinction between digital papillary adenocarcinoma and mimickers Open
Aims Digital papillary adenocarcinoma (DPA) is a rare sweat gland carcinoma arising on acral sites. The main differential diagnosis included tubular adenoma, hidradenoma, poroid hidradenoma, and mixed tumours, distinction between DPA and t…
View article: Primary cutaneous <scp>NUT</scp> adnexal carcinoma: morphologic, genetic and methylation analysis of seven new cases with comparison to extracutaneous <scp>NUT</scp> carcinoma and <i>NUTM1</i>‐rearranged porocarcinoma
Primary cutaneous <span>NUT</span> adnexal carcinoma: morphologic, genetic and methylation analysis of seven new cases with comparison to extracutaneous <span>NUT</span> carcinoma and <i>NUTM1</i>‐rearranged porocarcinoma Open
NUT carcinoma is a rare malignant neoplasm characterised by recurrent NUTM1 rearrangements, initially reported in the midline. Recently, 10 cases of cutaneous NUT carcinoma with adnexal differentiation harbouring BRD3::NUTM1 , NSD3::NUTM1 …
View article: Optimization of Adcitmer, a Monomethyl-Auristatin E bearing antibody-drug conjugate for the treatment of CD56-expressing cancers
Optimization of Adcitmer, a Monomethyl-Auristatin E bearing antibody-drug conjugate for the treatment of CD56-expressing cancers Open
The cell adhesion protein CD56 has been identified as a potential therapeutic target in several solid tumors and hematological malignancies. Recently, we developed a CD56-directed antibody-drug conjugate (ADC), called Adcitmer and demonstr…
View article: Cas n°4. Kystes cutanés
Cas n°4. Kystes cutanés Open
Cystic neoplasms are frequently observed on the skin. These can be classified into three categories: (1) malformative/dysembryoplastic cysts, (2) acquired cysts (constantly cystic tumors) of epidermal or folliculo-sebaceous differentiation…
View article: Recurrent <scp><i>GRHL</i></scp> fusions in a subset of sebaceoma: microscopic and molecular characterisation of eight cases
Recurrent <span><i>GRHL</i></span> fusions in a subset of sebaceoma: microscopic and molecular characterisation of eight cases Open
Aims Sebaceous neoplasms constitute a group of adnexal tumours, including sebaceous adenoma, sebaceoma and sebaceous carcinoma. Although mismatch repair deficiency may be observed, the nature of the genetic alterations contributing to the …
View article: Exploring the molecular landscape of cutaneous mixed tumors characterized by <scp> <i>TRPS1</i> </scp> :: <scp> <i>PLAG1</i> </scp> gene fusion
Exploring the molecular landscape of cutaneous mixed tumors characterized by <span> <i>TRPS1</i> </span> :: <span> <i>PLAG1</i> </span> gene fusion Open
The histological similarities between pleomorphic adenomas (PAs) and cutaneous mixed tumors (CMTs) found in certain facial regions can create a diagnostic challenge. Molecular findings reveal common genetic profiles, particularly PLAG1 rea…
View article: Exploring Patients’ Perceptions of One-step Surgery for Primary Cutaneous Melanoma: A Qualitative Study
Exploring Patients’ Perceptions of One-step Surgery for Primary Cutaneous Melanoma: A Qualitative Study Open
High-frequency ultrasonography (> 20 MHz) has allowed for preoperative measurement of melanoma thickness and thus a one-step surgery strategy. The potential benefits of one-step surgery to patients remain unexplored. From June 2022 to Augu…
View article: Re-evaluation of the concept of basaloid follicular hamartoma associated with naevoid basal cell carcinoma syndrome: a morphological, immunohistochemical and molecular study
Re-evaluation of the concept of basaloid follicular hamartoma associated with naevoid basal cell carcinoma syndrome: a morphological, immunohistochemical and molecular study Open
Naevoid basal cell carcinoma syndrome (NBCCS) is a rare genodermatosis caused by germline mutations in genes of the Sonic Hedgehog (SHH) pathway and is characterised by early onset of multiple basal cell carcinomas (BCCs). Although skin tu…
View article: Impact of the adjunction of a short video to an original article for the recognition of newly described tumor entities in pathology: An interventional prospective study
Impact of the adjunction of a short video to an original article for the recognition of newly described tumor entities in pathology: An interventional prospective study Open
Context Merkel cell carcinoma diagnosis is often based on microscopic examination by pathologists. While histopathologic diagnosis primarily hinges on conscious and analytical cognition, the pathologist's decision‐making process is also in…
View article: Merkel cell polyomavirus pan‐T antigen knockdown reduces cancer cell stemness and promotes neural differentiation independent of RB1
Merkel cell polyomavirus pan‐T antigen knockdown reduces cancer cell stemness and promotes neural differentiation independent of RB1 Open
Merkel cell carcinoma (MCC) is a highly aggressive skin cancer associated with integration of Merkel cell polyomavirus (MCPyV). MCPyV‐encoded T‐antigens (TAs) are pivotal for sustaining MCC's oncogenic phenotype, i.e., repression of TAs re…
View article: DNA Damage Stress Control Is a Truncated Large T Antigen and Euchromatic Histone Lysine Methyltransferase 2–Dependent Central Feature of Merkel Cell Carcinoma
DNA Damage Stress Control Is a Truncated Large T Antigen and Euchromatic Histone Lysine Methyltransferase 2–Dependent Central Feature of Merkel Cell Carcinoma Open
Merkel cell carcinoma (MCC) is an aggressive skin cancer with a high mortality rate. Merkel cell polyomavirus causes 80% of MCCs, encoding the viral oncogenes small T and truncated large T (tLT) antigens. These proteins impair the RB1-depe…
View article: Detection of wildtype Merkel cell polyomavirus genomic sequence and <scp>VP1</scp> transcription in a subset of Merkel cell carcinoma
Detection of wildtype Merkel cell polyomavirus genomic sequence and <span>VP1</span> transcription in a subset of Merkel cell carcinoma Open
Aims Merkel cell carcinoma (MCC) is frequently caused by the Merkel cell polyomavirus (MCPyV). Characteristic for these virus‐positive (VP) MCC is MCPyV integration into the host genome and truncation of the viral oncogene Large T antigen …
View article: Current and preclinical treatment options for Merkel cell carcinoma
Current and preclinical treatment options for Merkel cell carcinoma Open
Merkel cell carcinoma (MCC) is a rare, highly aggressive form of skin cancer with neuroendocrine features. The origin of this cancer is still unclear, but research in the last 15 years has demonstrated that MCC arises via two distinct etio…
View article: Gene fusions in poroma, porocarcinoma and related adnexal skin tumours: An update
Gene fusions in poroma, porocarcinoma and related adnexal skin tumours: An update Open
Poroma is a benign sweat gland tumour showing morphological features recapitulating the superficial portion of the eccrine sweat coil. A subset of poromas may transform into porocarcinoma, its malignant counterpart. Poroma and porocarcinom…
View article: Digital Papillary Adenocarcinoma in Nonacral Skin
Digital Papillary Adenocarcinoma in Nonacral Skin Open
Digital papillary adenocarcinoma (DPA) is a rare sweat gland neoplasm that has exceptionally been reported outside acral locations. Recently, human papillomavirus 42 was identified as the main oncogenic driver of DPA. Herein, we report 5 t…
View article: Sweat Gland Tumors Arising on Acral Sites
Sweat Gland Tumors Arising on Acral Sites Open
Recurrent oncogenic drivers have been identified in a variety of sweat gland tumors. Recently, integration of human papillomavirus type 42 (HPV42) has been reported in digital papillary adenocarcinoma (DPA). The main objectives of the pres…
View article: Recurrent <i>PAK2</i> rearrangements in poroma with folliculo‐sebaceous differentiation
Recurrent <i>PAK2</i> rearrangements in poroma with folliculo‐sebaceous differentiation Open
Aims Poroma is a benign adnexal neoplasm with differentiation towards the upper portion of the sweat gland apparatus. In 2019, Sekine et al. demonstrated recurrent YAP1::MAML2 and YAP1::NUTM1 fusion in poroma and porocarcinoma. Follicular,…
View article: 4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone Inhibits MCPyV T Antigen Expression in Merkel Cell Carcinoma Independent of Aurora Kinase A
4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone Inhibits MCPyV T Antigen Expression in Merkel Cell Carcinoma Independent of Aurora Kinase A Open
Merkel cell carcinoma (MCC) is frequently caused by the Merkel cell polyomavirus (MCPyV), and MCPyV-positive tumor cells depend on expression of the virus-encoded T antigens (TA). Here, we identify 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2H-ph…
View article: Acral <i>BRAF</i>‐mutated tubular adenoma should be distinguished from <scp>HPV42</scp>‐related digital papillary adenocarcinoma
Acral <i>BRAF</i>‐mutated tubular adenoma should be distinguished from <span>HPV42</span>‐related digital papillary adenocarcinoma Open
Notes and Comments
View article: Supplementary Table S2 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
Supplementary Table S2 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers Open
Viral abundance scores in ViroCap assay.
View article: Supplementary Table S4 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
Supplementary Table S4 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers Open
HPV42 integration sites in DPA.
View article: Supplementary Table S2 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
Supplementary Table S2 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers Open
Viral abundance scores in ViroCap assay.
View article: Supplementary Table S5 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
Supplementary Table S5 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers Open
FISH probes.
View article: Data from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
Data from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers Open
The skin is exposed to viral pathogens, but whether they contribute to the oncogenesis of skin cancers has not been systematically explored. Here we investigated 19 skin tumor types by analyzing off-target reads from commonly available nex…
View article: Supplementary Figures S1-S9 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
Supplementary Figures S1-S9 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers Open
Supplementary data depicted in Supplementary Figures S1-S9
View article: Supplementary Figures S1-S9 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
Supplementary Figures S1-S9 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers Open
Supplementary data depicted in Supplementary Figures S1-S9
View article: Supplementary Table S10 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
Supplementary Table S10 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers Open
HPV abundance scores TCGA.