Thibaut Sanchez
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Moesin controls cell–cell fusion and osteoclast function Open
Cell–cell fusion is an evolutionarily conserved process that is essential for many functions, including the formation of bone-resorbing multinucleated osteoclasts. Osteoclast multinucleation involves dynamic interactions between the actin …
Drosophila complement-like Mcr acts as a wound-induced inflammatory chemoattractant Open
Sterile tissue injury is accompanied by an acute inflammatory response whereby innate immune cells rapidly migrate to the site of injury guided by pro-inflammatory chemotactic damage signals released at the wound. Understanding this immune…
Cell Death and Infection: Implications for Host and Microbe Open
Cell death is a part of life. Every day, billions of cells undergo programmed cell death within the human body as part of normal tissue turnover and homeostasis. The factors that initiate programmed cell death, the resulting signalling pat…
Moesin controls cell-cell fusion and osteoclast function Open
Cell-cell fusion is an evolutionarily conserved process that is essential for many functions, including fertilisation and the formation of placenta, muscle and osteoclasts, multinucleated cells that are unique in their ability to resorb bo…
View article: The membrane-actin linkers ezrin, radixin, and moesin are dispensable for macrophage migration and cortex mechanics
The membrane-actin linkers ezrin, radixin, and moesin are dispensable for macrophage migration and cortex mechanics Open
The cellular actin cortex provides crucial mechanical support and plays critical roles in numerous functions, including cell division and migration. The proteins of the ERM family, ezrin, radixin, and moesin, are central to these processes…
Tissue Infiltration of Tumor-Associated Macrophages: Towards the Identification of Therapeutic Targets Open
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Genetic engineering of Hoxb8-immortalized hematopoietic progenitors – a potent tool to study macrophage tissue migration Open
Tumor-associated macrophages (TAMs) are detrimental in most cancers. Controlling their recruitment is thus potentially therapeutic. We previously found that TAMs perform protease-dependent mesenchymal migration in cancer, while macrophages…
Genetic engineering of hoxb8 immortalized hematopoietic progenitors: a potent tool to study macrophage tissue migration Open
Tumor-associated macrophages (TAM) are detrimental in most cancers. Controlling their recruitment is thus potentially therapeutic. We showed that TAM perform the protease-dependent mesenchymal migration in cancer, while macrophages perform…